Choice of Stimulus Range and Size Can Reduce Test-Retest Variability in Glaucomatous Visual Field Defects

Swanson, William H.; Horner, Douglas G.; Dul, Mitchell W.; Malinovsky, Victor E.

doi:10.1167/tvst.3.5.6

Cited by 16 publications

(38 citation statements)

References 44 publications

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“…16–18 Increased variability with reductions in sensitivity is not present for frequency-doubling perimetry. 18–23 Good reproducibility for FDT may also have a role in enhancement of structure–function relationships in glaucoma with PFS. 42,54 Short-wavelength automated perimetry had a relatively high degree of variability than that for white-on-white perimetry, such as SAP.…”

Section: Discussionmentioning

confidence: 96%

“…54 Test–retest variability was lower with FDT compared to SAP using size III stimuli. 18–23 These variability properties of FDT could result from increased stimulus size or decreased stimulus range. 18 Test–retest variability of VF by SAP is greater within and near glaucomatous VF defects than to regions with normal sensitivity.…”

Section: Discussionmentioning

confidence: 99%

“…18–23 These variability properties of FDT could result from increased stimulus size or decreased stimulus range. 18 Test–retest variability of VF by SAP is greater within and near glaucomatous VF defects than to regions with normal sensitivity. 16–18 Increased variability with reductions in sensitivity is not present for frequency-doubling perimetry.…”

Section: Discussionmentioning

confidence: 99%

“…The peripheral nasal step group had abnormal points within 12 nasal peripheral points ( dotted line ) in one hemifield. ( B ) Structure–function correspondence map according to Garway-Heath et al 18 ( B-1 ) Visual field sectors ( B-2 ) and peripapillary RNFL thickness. SN, superonasal; N, nasal: IN, inferonasal; IT, inferotemporal; T, temporal; ST, superotemporal.…”

Section: Methodsmentioning

confidence: 99%

“…15 Test–retest variability of VF by SAP is greater within and near glaucomatous VF defects than to regions with normal sensitivity. 16–18 Increased variability with reductions in sensitivity is not present for frequency-doubling perimetry. 18–23 …”

mentioning

confidence: 96%

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Structure–Function Relationship in Glaucoma Patients With Parafoveal Versus Peripheral Nasal Scotoma

Jung

Kang

Choi

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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PurposeWe evaluated whether the structure–function relationship in glaucoma patients with parafoveal scotoma or peripheral scotoma differs with the use of frequency doubling technology (FDT) or short-wavelength automated perimetry (SWAP) compared to standard automated perimetry (SAP).MethodsGlaucoma patients with isolated parafoveal scotoma (PFS) within the central 10° of fixation in 1 hemifield and those with an isolated peripheral nasal step (PNS) within the nasal periphery outside 10° of fixation in one hemifield were studied. Peripapillary retinal nerve fiber layer (RNFL) thickness was measured using spectral-domain optical coherence tomography. The topographic relationships between structure and function were investigated.ResultsIn the PNS group, superotemporal (r2 = 0.300, P = 0.001) and inferotemporal (r2 = 0.302, P = 0.001) RNFL thickness showed significant correlations with the corresponding visual field (VF) sensitivity using linear regression model in SAP. In the PFS group, temporal RNFL thickness was not correlated with nasal mean sensitivity (MS) on SAP (r2 = 0.103, P = 0.065). Using FDT, however, the temporal RNFL thickness was correlated with nasal MS in the PFS group (r2 = 0.277, P = 0.001). Using SWAP, the temporal RNFL thickness was not significantly associated with regional VF sensitivity in the PFS group (r2 = 0.052, P = 0.192).ConclusionsIn glaucoma with peripheral scotoma, the RNFL thickness was associated significantly with the corresponding VF loss in SAP, FDT, and SWAP. In eyes with PFS, however, the topographic structure–function relationships were not distinct with SAP or SWAP. Frequency doubling technology performed well in terms of structure–function correlation in glaucoma with PFS.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 96%

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Structure–Function Relationship in Glaucoma Patients With Parafoveal Versus Peripheral Nasal Scotoma

Jung

Kang

Choi

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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Online Circular Contrast Perimetry: A Comparison to Standard Automated Perimetry

Meyerov

Deng

Busija

et al. 2023

Asia-Pacific Journal of Ophthalmology

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Purpose: The aim was to validate and compare the diagnostic accuracy of a novel 24-degree, 52-loci online circular contrast perimetry (OCCP) application to standard automated perimetry (SAP). Design: Prospective cohort study. Methods: Two hundred and twenty participants (125 normal controls, 95 open angle glaucoma patients) were included. Agreement, correlation, sensitivity, specificity, and area under receiver operating curves (AUC) were compared for parameters of OCCP, SAP, and optical coherence tomography (OCT) for the retinal nerve fiber layer and macular ganglion cell complex inner plexiform layer. Results: Pointwise sensitivity for OCCP was greater than SAP by 1.02 log units (95% CI: 0.95–1.08); 95% limits of agreement 0.860 to 1.17. Correlation and agreement for global indices and regional zones between OCCP and SAP were strong. OCCP mean deviation (MD) AUC was 0.885±0.08, similar to other instruments’ parameters with the highest AUC: SAP MD (0.851±0.08), OCT retinal nerve fiber layer inferior thickness (0.908±0.07), OCT ganglion cell complex inner plexiform layer inferior thickness (0.849±0.08), P>0.05. At best cutoff, OCCP MD sensitivity/specificity were comparable to SAP MD (90/74 vs 94/65%). Conclusions: OCCP demonstrates similar perimetric sensitivities to SAP and similar AUC to SAP and OCT in distinguishing glaucoma patients from controls. OCCP holds promise as a glaucoma surveillance and screening tool, with the potential to be utilized for in-clinic and at-home perimetry and expand community testing.

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Usefulness of frequency doubling technology perimetry 24-2 in glaucoma with parafoveal scotoma

Jung

Kim²,

Park³

2017

Medicine

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The standard automated perimetry (SAP) 24-2 test cannot adequately test the paracentral region because test points are located sparsely in macular area where is crowded with retinal ganglion cells (RGCs), even though paracentral scotoma is clinically related to a risk of losing visual function. More sensitive visual field (VF) tests are needed to assess paracentral VF defects precisely. We investigated the structure–function relationship on the SAP 10-2 test and the frequency doubling technology (FDT) 24-2 test as well as the SAP 24-2 test in glaucoma with parafoveal scotoma (PFS). Glaucoma patients with PFS (134 patients) were included in this cross-sectional study. Sub-analysis was performed with isolated PFS (51 patients). Global and sectoral mean sensitivities (MS) were evaluated using SAP 24-2, 10-2, and FDT 24-2 program. MS was analyzed as dB or unlogged 1/lambert (SAP) or 1/Michelson contrast (FDT). Ganglion cell-inner plexiform layer (GCIPL) thickness was measured using spectral domain optical coherence tomography. Topographic relationships between the structure and the function were analyzed. In the total PFS group, good structure–function correlations were found in all zones with SAP 24-2, 10-2, and FDT 24-2 test. For glaucoma with isolated PFS, average GCIPL thickness was significantly correlated with central cluster MS (dB) using the SAP 10-2 test (r = 0.279, P = .047) and the FDT 24-2 test (r = 0.289, P = .039), but not the SAP 24-2 test (r = 0.264, P = .061). Topographically, the FDT 24-2 test showed significant correlations in all sectors between sectoral MS and corresponding GCIPL thickness. With regard to the SAP 10-2 test, there was significant topographical structure–function correlations for the superotemporal, inferotemporal, and inferonasal sectors. For SAP 24-2, only inferonasal GCIPL thickness was correlated with the corresponding VF sensitivity. Topographical structure–function on the macula was better with the SAP 10-2 test (superotemporal sector) and the FDT 24-2 test (superotemporal sector) than with the SAP 24-2 test in glaucoma with isolated PFS. In conclusion, FDT 24-2 and SAP 10-2 tests performed more favorably than the SAP 24-2 test in the structure–function relationship of glaucoma patients with isolated paracentral scotoma. FDT 24-2 tests can be another good option for detecting and monitoring RGC loss on the macular area while not missing VF defects outside the central 10°.

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Choice of Stimulus Range and Size Can Reduce Test-Retest Variability in Glaucomatous Visual Field Defects

Cited by 16 publications

References 44 publications

Structure–Function Relationship in Glaucoma Patients With Parafoveal Versus Peripheral Nasal Scotoma

Structure–Function Relationship in Glaucoma Patients With Parafoveal Versus Peripheral Nasal Scotoma

Online Circular Contrast Perimetry: A Comparison to Standard Automated Perimetry

Usefulness of frequency doubling technology perimetry 24-2 in glaucoma with parafoveal scotoma

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