Usefulness of frequency doubling technology perimetry 24-2 in glaucoma with parafoveal scotoma

Jung, Kyoung In; Kim, Eun Kyoung; Park, Chan Kee

doi:10.1097/md.0000000000006855

Cited by 7 publications

(7 citation statements)

References 31 publications

(43 reference statements)

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“…Neurofilaments (NFs), a major component of the neuronal cytoskeleton, are believed to function primarily to provide structural support for the axon and to regulate axon diameter 25 , 26 . When optic nerve and retina sections of all rats were therefore stained with the NF antibody (Fig.…”

Section: Resultsmentioning

confidence: 99%

Matrine treatment reduces retinal ganglion cell apoptosis in experimental optic neuritis

Kang

Liu

Song

et al. 2021

Sci Rep

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Inflammatory demyelination and axonal injury of the optic nerve are hallmarks of optic neuritis (ON), which often occurs in multiple sclerosis and is a major cause of visual disturbance in young adults. Although a high dose of corticosteroids can promote visual recovery, it cannot prevent permanent neuronal damage. Novel and effective therapies are thus required. Given the recently defined capacity of matrine (MAT), a quinolizidine alkaloid derived from the herb Radix Sophorae flavescens, in immunomodulation and neuroprotection, we tested in this study the effect of matrine on rats with experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. MAT administration, started at disease onset, significantly suppressed optic nerve infiltration and demyelination, with reduced numbers of Iba1+ macrophages/microglia and CD4+ T cells, compared to those from vehicle-treated rats. Increased expression of neurofilaments, an axon marker, reduced numbers of apoptosis in retinal ganglion cells (RGCs). Moreover, MAT treatment promoted Akt phosphorylation and shifted the Bcl-2/Bax ratio back towards an antiapoptotic one, which could be a mechanism for its therapeutic effect in the ON model. Taken as a whole, our results demonstrate that MAT attenuated inflammation, demyelination and axonal loss in the optic nerve, and protected RGCs from inflammation-induced cell death. MAT may therefore have potential as a novel treatment for this disease that may result in blindness.

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Section: Resultsmentioning

confidence: 99%

Matrine treatment reduces retinal ganglion cell apoptosis in experimental optic neuritis

Kang

Liu

Song

et al. 2021

Sci Rep

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show abstract

“…115,119,120 FDT has been used in glaucoma patients to assess the relationship between ganglion cell-inner plexiform layer (GCIPL) thickness and mean sensitivities and showed strong statistically significant positive correlations between the two, most notably in the inferotemporal and inferior sectors. 121 Several studies have explored neurological dysfunction of this pathway in patients with schizophrenia using FDT as well. Khosravani and Goodarzi reported diminished visual field sensitivity in patients with schizophrenia compared with normal controls.…”

Section: Schizophreniamentioning

confidence: 99%

Retinal correlates of psychiatric disorders

Almonte

Capellàn

Yap

et al. 2020

Therapeutic Advances in Chronic Disease

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Diagnosis and monitoring of psychiatric disorders rely heavily on subjective selfreports of clinical symptoms, which are complicated by the varying consistency of accounts reported by patients with an impaired mental state. Hence, more objective and quantifiable measures have been sought to provide clinicians with more robust methods to evaluate symptomology and track progression of disease in response to treatments. Owing to the shared origins of the retina and the brain, it has been suggested that changes in the retina may correlate with structural and functional changes in the brain. Vast improvements in retinal imaging, namely optical coherence tomography (OCT) and electrodiagnostic technology, have made it possible to investigate the eye at a microscopic level, allowing for the investigation of potential biomarkers in vivo. This review provides a summary of retinal biomarkers associated with schizophrenia, bipolar disorder and major depression, demonstrating how retinal biomarkers may be used to complement existing methods and provide structural markers of pathophysiological mechanisms that underpin brain dysfunction in psychiatric disorders.

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“…Neuro laments (NFs), a major component of the neuronal cytoskeleton, are believed to function primarily to provide structural support for the axon and to regulate axon diameter (24,25). When optic nerve and retina sections of all rats were therefore stained with the NF antibody ( Fig.…”

Section: Mat Treatment Reduces Axonal Loss In the Optic Nerve And Retinamentioning

confidence: 99%

Matrine protects retinal ganglion cells from apoptosis in experimental optic neuritis

Kang¹,

Liu²,

Song³

et al. 2020

Preprint

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Background: Inflammatory demyelination and axonal injury of the optic nerve are hallmarks of optic neuritis (ON), which often occurs in multiple sclerosis and is a major cause of visual disturbance in young adults. Although a high dose of corticosteroids can promote visual recovery, it cannot prevent permanent neuronal damage. Novel and effective therapies are thus required. Given the recently defined capacity of matrine (MAT), a quinolizidine alkaloid derived from the herb Radix Sophorae flavescens, in immunomodulation and neuroprotection, we tested in this study the effect of matrine on rats with experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. Results: MAT administration, started at disease onset, significantly suppressed optic nerve infiltration and demyelination, with reduced numbers of Iba1 + macrophages/microglia and CD4 + T cells, compared to those from vehicle-treated rats. Increased expression of neurofilaments, an axon marker, reduced numbers of apoptosis in retinal ganglion cells (RGCs), and reduced numbers of Iba1 + macrophages/microglia and CD4 + T cells were also observed in the retina after MAT treatment. Conclusions: Taken as a whole, our results demonstrate that MAT attenuated inflammation, demyelination and axonal loss in the optic nerve, and protected RGCs from inflammation-induced cell death. MAT may therefore have potential as a novel treatment for this disease that may result in blindness.

show abstract

Usefulness of frequency doubling technology perimetry 24-2 in glaucoma with parafoveal scotoma

Cited by 7 publications

References 31 publications

Matrine treatment reduces retinal ganglion cell apoptosis in experimental optic neuritis

Matrine treatment reduces retinal ganglion cell apoptosis in experimental optic neuritis

Retinal correlates of psychiatric disorders

Matrine protects retinal ganglion cells from apoptosis in experimental optic neuritis

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