Choice of capillary electrophoresis systems for the impurity profiling of drugs

Potential of Capillary Electrophoresis for the Profiling of Propolis

“…Naturally, the separation of the charged analytes should be maintained in the MEKC system. In a previous paper [26] we have demonstrated that a MEKC system containing 25 mM borate (pH 9.3) 50 mM SDS and 10% ACN provides a large migration window (i.e. relatively high resolution) with reasonable analysis times for both charged and neutral compounds.…”

Impurity analysis of pharmaceuticals using capillary electromigration methods

“…Fluvoxamine and its impurities were separated using cetyltrimethylammonium bromide as cationic surfactant and the effects of surfactant and organic modifier on separation factors were investigated [84].…”

Development of a CZE method for the determination of mizolastine and its impurities in pharmaceutical preparations using response surface methodology

“…Quantitative testing of impurities is an important aspect of drug analysis [5,6]. CE is now recognised as an alternative and complement to HPLC for pharmaceutical applications [7,8], and numerous papers on impurity profile evaluation by CZE have been presented [6,[9][10][11][12][13][14][15].…”

“…CE is now recognised as an alternative and complement to HPLC for pharmaceutical applications [7,8], and numerous papers on impurity profile evaluation by CZE have been presented [6,[9][10][11][12][13][14][15]. In addition, multivariate strategies can be applied in the development of CZE [16][17][18][19], MEKC [20,21] and microemulsion elektrokinetic chromatography (MEEKC) [22] methods for the determination of related substances.…”