Chlortetracycline and sulfanilamide residues in table eggs: Prevalence, distribution between yolk and white and effect of refrigeration and heat treatment

Alaboudi, Akram R.; Abu‐Basha, Ehab A.; Musallam, Imadidden

doi:10.1016/j.foodcont.2013.03.014

Cited by 37 publications

(30 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The primary reason for the differences in the conclusions of the studies mentioned above is probably the fact that they investigated different drugs and were performed under different experimental conditions. In addition, multifactorial causes including the oral bioavailability of the investigated drug and its physiochemical properties (molecular weight and solubility), the physiology of the chicken specimens as well as differences in the egg formation properties, organ perfusion characteristics, and tissue composition could also be likely reasons (Alaboudi, Basha, & Musallam, ; Bilandzic et al., ; Donoghue & Myers, ; Kan, ; Munoz et al., ). Roudaut and Moretain () stated that the differences in the sensitivities of the analytical methods used to detect drugs in egg matrices could also be a reason for the differences observed in their deposition patterns.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Tilmicosin Contamination in Eggs Following Its Administration to Laying Hens and Subsequent Assessment of Dietary Risks to Chinese Consumers

Yang

Wang

et al. 2019

Journal of Food Science

View full text Add to dashboard Cite

In the present study, we analyzed the tilmicosin residues in eggs as well as the dietary risks posed by the residual drug to Chinese consumers. Tilmicosin was administrated to laying hens via drinking water in doses of 100 mg/L and 300 mg/L (dose 1 and dose 2) for 5 days. Its residues distribution within egg matrices were detected using a QuEChERS method coupled with liquid chromatography–tandem mass spectrometry (LC‐MS/MS). The results indicated that the tilmicosin residue was the highest in the whole eggs and yolks on day 2 after medication and in the whites on day 5 of drug administration for dose 1 and dose 2 with the residues (µg/kg) being the following: 73.4 and 444.3 in the whole eggs; 152.0 and 1141.1 in the yolks; and 48.8 and 277.6 in the whites, respectively. During withdrawal phase, the tilmicosin levels declined to less than the limit of detection (LOD) after 29 days and 49 days for the whole eggs, after 24 days and 44 days for the yolks, and after 19 days and 49 days for the whites for doses 1 and 2, respectively. An assessment of the dietary risk for Chinese consumers revealed that the hazard quotients (HQ) values for tilmicosin consumption were less than 1 for dose 1 and greater than 1 for dose 2, with children (2 to 7 years) and adult males (over 65 years) being the high‐risk groups. These results suggest that the possible risk associated with tilmicosin contamination in eggs should not be ignored since the accidental or occasional misuse of tilmicosin in the case of egg‐laying hens may occur from time to time, particularly on small farms. Practical Application The modified QuEChERS method was used to analyze the tilmicosin residues in egg matrices and a subsequent dietary exposure assessment for Chinese consumers was performed, which can serve as a reference for the food safety risk posed by antibiotic misuse in egg layers.

show abstract

Section: Resultsmentioning

confidence: 99%

Evaluation of Tilmicosin Contamination in Eggs Following Its Administration to Laying Hens and Subsequent Assessment of Dietary Risks to Chinese Consumers

Yang

Wang

et al. 2019

Journal of Food Science

View full text Add to dashboard Cite

show abstract

“…HPLC makes it possible to determine tetracycline at a level of hundredths of μg/mL. Food products and feed IC [46] Meat HPLC [15], [19], [21][22][23], [27], [51] SP [85] IC [16][17][18], [20], [27] VA [24], [31] SP [85] Environmental samples VA [24] Water HPLC [72], [86], [89], [93], [94], [100], [ Eggs HPLC [27], [32], [53], [68], [134] FL [117], [119], [156] IC [18], [27] …”

Section: Determination Methodsmentioning

confidence: 99%

“…Photometric UV [23,51,53,60,73,74,80,81,89,113,124,134], diode array [15,19,22,29,37,55,68,72,84,86,138,139], and fluorescence [34,58,71,83,93,94] detectors are used for the detection of tetracy cline antibiotics. The number of works regarding the determination of tetracycline antibiotics by the HPLC with a mass spectrometric detector noticeably increased [15,21,27,32,35,69,100,105,106,112,114].…”

Section: Ms-dart [157]mentioning

confidence: 99%

Methods for the separation, preconcentration, and determination of tetracycline antibiotics

2015

View full text Add to dashboard Cite

The data published in the last five years concerning the determination of tetracycline antibiotics in different samples are generalized. Sample preparation procedures for real samples, including liquid extrac tion from solid matrices, pressurized liquid extraction, matrix solid phase dispersion, QuEChERS method, and solid phase extraction, are compared. The following important determination techniques are discussed: chromatographic, electrophoretic, spectroscopic, and electrochemical. The determination of the above anti biotics in food products, feed, environmental samples, pharmaceuticals, and biological fluids is exemplified.

show abstract

“…However, our study revealed high concentrations of AMO in the yolk. Thus, single factors, such as the pH or lipid solubility, cannot sufficiently explain the distribution of drugs in the egg white and yolk (Alaboudi et al, 2013). Indeed, the distribution of drugs in eggs may be affected by the formation mechanism of the albumen and yolk.…”

Section: Residue Depletionmentioning

confidence: 99%

Residue depletion of amoxicillin and its major metabolites in eggs

Liu

Pang

Xie

et al. 2016

Vet Pharm & Therapeutics

View full text Add to dashboard Cite

The depletion of amoxicillin (AMO) and its major metabolites, amoxicilloic acid (AMA) and amoxicillin-diketopiperazine-2',5'-dione (DIKETO) in the albumen, yolk and whole egg was studied after the oral dose of AMO (25 and 50 mg/kg body weight) to laying hens once per day for five consecutive days. Egg samples were prepared by a simple liquid-liquid extraction procedure with acetonitrile and saturated methylene chloride and analysed using liquid chromatography-tandem mass spectrometry. The results showed that AMO, AMA and DIKETO residues were mainly distributed in the yolk, where particularly high concentrations of AMO and DIKETO were found, whereas the albumen contained high concentrations of AMA. This distribution suggested that AMO and DIKETO were depleted slowly in yolk, whereas AMA was depleted slowly in albumen. The amount of AMO residue positively correlated with the dose, and the theoretical withdrawal times, which were calculated based on the residue level falling below a safe limit, were 5.21 and 7.67 days at AMO doses of 25 and 50 mg/kg, respectively. Moreover, the theoretical withdrawal times for all residues in the whole egg were 8.00 and 9.11 days at doses of 25 and 50 mg/kg, respectively. Our findings suggested that 9 days was an appropriate withdrawal time for the use of AMO in laying hens.

show abstract

Chlortetracycline and sulfanilamide residues in table eggs: Prevalence, distribution between yolk and white and effect of refrigeration and heat treatment

Cited by 37 publications

References 24 publications

Evaluation of Tilmicosin Contamination in Eggs Following Its Administration to Laying Hens and Subsequent Assessment of Dietary Risks to Chinese Consumers

Evaluation of Tilmicosin Contamination in Eggs Following Its Administration to Laying Hens and Subsequent Assessment of Dietary Risks to Chinese Consumers

Methods for the separation, preconcentration, and determination of tetracycline antibiotics

Residue depletion of amoxicillin and its major metabolites in eggs

Contact Info

Product

Resources

About