Chlorpropamide Poisoning and Diabetes Insipidus

Troyer, André De; Ectors, Michel Paul; Hubert, J.P.

doi:10.1016/s0140-6736(75)90602-9

Cited by 4 publications

(2 citation statements)

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“…Her symptomssuch as polydipsia and polyuria disappeared within 7 days after the cessation of lobenzarit therapy. Druginduced NDIhas been described after administration of lithium carbonate ( 1 ), democlocycline hydrochloride (3), amphotericin B (4), cyclophosphamide (5), riphampicin (6), streptozocin (7), and chlorpropamide (2). The symptoms disappeared after the discontinuation of these drugs.…”

Section: Discussionmentioning

confidence: 99%

“…Nephrogenic diabetes insipidus (NDI) occurs both as a rare X-linked genetic disorder, and more commonly,as a complication oftherapies with lithium carbohydrate ( 1 ) , chlorpropamide (2) and various other drugs. Lobenzarit disodium, which was developed in Japan, has been often used as a disease-modifying antirheumatic drug for the treatment of rheumatoid arthritis (RA) in Japan for the past 7 years.…”

Section: Introductionmentioning

confidence: 99%

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Nephrogenic Diabetes Insipidus Induced by Lobenzarit Disodium Treatment in Patients with Rheumatoid Arthritis.

et al. 1996

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Nephrogenic diabetes insipidus (NDI) occurred in a 43-year-old woman who had received lobenzarit disodium for the treatment of rheumatoid arthritis (RA). Her urine output was initially 3 //day and urine osmolarity was 203 mOsm//. Based on a sodium chloride loading test and a vasopressin loading test, she was diagnosed as having lobenzarit-induced NDI. Seven days after the cessation of the use of lobenzarit disodium, polydipsia and polyuria disappeared, and the vasopressin test showed a normal response. These findings suggest that lobenzarit induces a reversible form ofNDI as a side effect. The reports oflobenzarit-induced NDI in Japan during the past seven years are also reviewed.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%