Chlorpropamide-induced hypoglycemia

Topics in Clinical Pharmacology and Therapeutics

“…Similar hemodynamic improvement is noted when the DA2 agonist propylbutyldopamine is given intravenously (117). The DAl agonist ibopamine has been used orally to treat heart failure (118), and the oral agent SKF 82526 (119) is currently undergoing preliminary clinical trials. The potential advantage of the DA2 agonists is that, in addition to promoting vasodilation, they reduce the heightened sympathetic drive seen in heart failure, which is possibly contributing to the pathophysiology of the heart failure state (18).…”

“…The primary mechanism of action is blockade of the conversion of angiotensin I to angiotensin II, a direct vasoconstrictor and mediator of aldosterone secretion, although additional mechanisms have been suggested (118). The primary mechanism of action is blockade of the conversion of angiotensin I to angiotensin II, a direct vasoconstrictor and mediator of aldosterone secretion, although additional mechanisms have been suggested (118).…”

“…Captopril effectively lowers BP in hypertension of all degrees of severity, although until recently it had been primarily reserved for resistant or renovascular hypertension (118,119). Severe side effects of neutropenia and proteinuria were reported in early studies, where renal insufficiency and high doses resulted in what is now known to be excessive blood levels of captopril.…”

“…Early studies, summarized by Glassroth et al (118), showed a reduction of 60-90% in tuberculous case rates among subjects treated with isoniazid as compared with those 271 given placebo. Early studies, summarized by Glassroth et al (118), showed a reduction of 60-90% in tuberculous case rates among subjects treated with isoniazid as compared with those 271 given placebo.…”

Extended-Release Glipizide Overdose Presenting with Delayed Hypoglycemia and Treated with Subcutaneous Octreotide

“…Her initial treatment with glucagon by the EMS was appropriate for her initial presentation with hypoglycemia of unknown etiology. However, glucagon is not the ideal antidote for a known sulfonylurea ingestion, as glucagon further stimulates endogenous insulin secretion (12). Glucose administration, either oral or intravenous, is the recommended treatment for sulfonylurea-induced hypoglycemia, but this was insufficient to treat this patient’s hypoglycemia.…”