Chlorpropamide in Diabetes Insipidus

Kumar, Rahul; Sutow, Wataru W.; Cole, V. William

doi:10.1016/s0140-6736(69)91996-5

Cited by 14 publications

(3 citation statements)

References 7 publications

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“…Patients with cranial d.i. and insufficiency of the anterior pituitary gland have been reported to be especially sensitive to the hypoglycaemic action of chlorpropamide (16,27). In these cases DDAVP offers a safe alternative treatment.…”

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Effects of Ddavp, a Synthetic Analogue of Vasopressin, in Patients With Cranial Diabetes Insipidus

Andersson

Arner

1972

Journal of Internal Medicine

105

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DDAVP, 1‐deamino‐8‐D‐arginine vasopressin, is a synthetic analogue of vasopressin with a higher anti‐diuretic potency, less vasopressor activity, and a longer duration of action than the vasopressin preparations at present in clinical use. The effects of DDAVP have been studied in ten patients with vasopressin sensitive diabetes insipidus previously treated with 8‐lysine vasopressin, chlorpropamide, chlorthalidone, or combinations of these substances. Five patients were given 1 or 2 μg DDAVP i.v., and the effect of these amounts lasted from 5 to more than 12 hours compared with 45–90 min for corresponding amount of 8‐lysine vasopressin. In all ten patients DDAVP administered intranasally in doses of 15 μg one to three times daily normalized the urine production also in cases where previous therapy had failed. No side‐effects have been observed during treatment with DDAVP for 6–12 months. It is concluded that DDAVP, because of its freedom from side‐effects and long duration of action, is a safe and effective substance in the treatment of cranial diabetes insipidus.

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confidence: 99%

Effects of Ddavp, a Synthetic Analogue of Vasopressin, in Patients With Cranial Diabetes Insipidus

Andersson

Arner

1972

Journal of Internal Medicine

105

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“…Other drugs with antidiuretic properties, such as thiazides (Lant and Wilson, 1971), carbamazepine (Tegretol) (Delzant, Sebaoun, and Krivitzky, 1971;Stoll, Largier, and Tonz, 1972), clofibrate (De Gennes et al, 1970), and chlorpropamide (Kumar, Sutow, and Cole, 1969;Ehrlich and Kooh, 1970;Reimold, 1970), have been tested with varying results. Largely unsatisfactory results as well as unpleasant side effects have been reported (Pinto and Stoppoloni, 1970).…”

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confidence: 99%

A vasopressin analogue in treatment of diabetes insipidus

Kauli¹,

Laron²

1974

Archives of Disease in Childhood

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A vasopressin analogue in treatment of diabetes insipidus. Six children, 3 adolescents, and 3 adults with vasopressin-sensitive diabetes insipidus were treated with a vasopressin analogue, DDAVP (1-deamino-8-D-arginine vasopressin), at a daily dose ranging from 5 to 20 ,ug administered twice a day intranasally. The period of follow-up of these patients has been from 3 months to 1 year.DDAVP was effective in maintaining normal diuresis and normal urine concentration during both day and night. No local or vasopressor side effects were observed. Compared to other antidiuretic drugs, such as nasal pitressin powder, lysine-vasopressin nasal spray, or pitressin tannate injections, used previously by the patients, DDAVP proved to be superior in the control of the diabetes insipidus and in the subjective feeling of the patients.It is concluded that DDAVP is the drug of choice in the treatment of vasopressinsensitive diabetes insipidus.Good control of diabetes insipidus is especially important in children since, in addition to the interference with normal school attendance, social activities, and night rest, normal growth is disturbed by the imbalance in water and electrolyte metabolism. Up to now none of the drugs employed have proved satisfactory and some have caused troublesome side effects.We report our experience with a new antidiuretic preparation, DDAVP (1-deamino-8-D-arginine vasopressin), a synthetic analogue of the natural human antidiuretic hormone. Its features are a lack of pressor activity and side effects, together with a prolonged antidiuretic action. Subjects and methodsTwelve patients (7 females and 5 males) with diabetes insipidus were included in this study. 9 were children or adolescents (5 years 9 months to 18 years) and 3 were adults. 2 of the adult patients (aged 224 and 24 years) have been under our care since childhood, while the third, a 34-year-old patient with a pituitary tumour, was under the care of the Department of Neurosurgery.The pertinent clinical data are summarized in Table I.

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“…The excellent antidiuretic effect of oral and intravenous chlorpropamide has been confirmed in several patients with pituitary diabetes insipidus as well as in normal subjects during water diuresis [2,4,8,9,11). On the other hand, a number of chlorpropamide refractory cases of diabetes insipidus have also been reported and, therefore, the clinical value of this therapy is in dispute [2,3,10]. In preliminary studies it was found that during chronic oral chlorpropamide therapy the higher the chlorpropamide dose the greater the antidiuretic effect [8,11].…”

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confidence: 99%