Chlorpromazine-induced lupuslike disease

Phenothiazine‐induced systemic lupus erythematosus with superior vena cava syndrome: case report and review of the literature

“…Gold and Sweeney (6) described a young woman with schizophrenia whose only therapy had been perphenazine (24-40 mglday) and who had a drug-induced lupus-like illness. Additional cases of chlorpromazine-induced lupus have been reported by Dubois et a1 (7), Ananth and Minn (8), and Pavlidasky et al (9).…”

“…None of these patients, however, had clinical evidence of SLE. (2) Fabius and Gaulhofer (5) Gold and Sweeny (6) Dubois et a1 (7) Ananth and Minn (8) Pavlidasky et a1 (9) Zucker et a1 (10) Recently, there have been numerous reports of arterial and venous thromboses occurring in patients with CAC. Episodes of deep vein thrombophlebitis, pulmonary embolism, and myocardial and cerebral infarction have been reported to be increased in patients with CAC (13).…”