Chlorous acid is a more potent antibacterial agent than sodium hypochlorite against Campylobacter

Hatanaka, Noritoshi; Awasthi, Sharda Prasad; Goda, Hisataka; Kawata, Hiroyuki; Uchino, Yuzuru; Kubo, Takahiro; Aoki, Shigeru; Hinenoya, Atsushi; Yamasaki, Shinji

doi:10.1016/j.foodcont.2019.107046

Cited by 9 publications

(6 citation statements)

References 16 publications

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“…In our previous study, we have examined the antibacterial activity of HClO 2 against Campylobacter jejuni and C. coli , and compared with that of NaClO. The data also indicated that HClO 2 has more potent antibacterial activity than NaClO regardless of presence and absence of organic matter [ 16 ]. Although the concentration of disinfectants used in this study was very low in comparison to that in the protocol of WHO [ 8 ], it is important to know the minimum antiviral concentration of disinfectant because an overdose of any disinfectant may be harmful for humans as well as for the environment.…”

Section: Resultsmentioning

confidence: 99%

Comparative evaluation of chlorous acid and sodium hypochlorite activity against SARS-CoV-2

Hatanaka

Awasthi

Xu³

et al. 2022

Access Microbiology

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A novel coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), suddenly emerged in China in 2019, spread globally and caused the present COVID-19 pandemic. Therefore, to mitigate SARS-CoV-2 infection effective measures are essential. Chlorous acid (HClO2) has been shown to be an effective antimicrobial agent. However, at present there is no experimental evidence showing that HClO2 can inactivate SARS-CoV-2. Therefore, in this study, we examined the potential of HClO2 to inactivate SARS-CoV-2 in presence or absence of organic matter and the results were compared with that of sodium hypochlorite (NaClO), another potent antimicrobial agent. When concentrated SARS-CoV-2 was incubated with 10 ppm HClO2 for 10 s, viral titre was decreased by 5 log of 50% tissue culture infective dose per mL (TCID50 ml−1). However, the same concentration of NaClO could not inactivate SARS-CoV-2 as effectively as HClO2 did even after incubation for 3 min. Furthermore, 10 ppm HClO2 also inactivated more than 4.0 log of TCID50 within 10 s in the presence of 5 % fetal bovine serum used as mixed organic matters. Our results obtained with HClO2 are more effective against SARS-CoV-2 as compared to NaClO that can be used for disinfectant against SARS-CoV-2 .

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Section: Resultsmentioning

confidence: 99%

Comparative evaluation of chlorous acid and sodium hypochlorite activity against SARS-CoV-2

Hatanaka

Awasthi

Xu³

et al. 2022

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“…ASC solution has recently received much attention as a disinfectant in the food industry [10][11][12][13][14][15][16][17]. There are several studies that clarify the microbicidal and sterilization effect of ASC aqueous solution/chlorous acid [18][19][20]. There is no evidence, however, that points to which active molecules produce this microbicidal and sterilizing effect.…”

Section: Introductionmentioning

confidence: 99%

Identifying the chloroperoxyl radical in acidified sodium chlorite solution

Kawata¹,

Kohno

Nukina³

et al. 2021

PLoS ONE

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The present study identified the active radical species in acidic sodium chlorite and investigated the feasibility of quantifying these species with the diethylphenylenediamine (DPD) method. Electron spin resonance (ESR) spectroscopy was used to identify the active species generated in solutions containing sodium chlorite (NaClO2). The ESR signal was directly observed in an acidified sodium chlorite (ASC) aqueous solution at room temperature. This ESR signal was very long-lived, indicating that the radical was thermodynamically stable. The ESR parameters of this signal did not coincide with previously reported values of the chlorine radical (Cl●) or chlorine dioxide radical (O = Cl●-O and O = Cl-O●). We refer to this signal as being from the chloroperoxyl radical (Cl-O-O●). Quantum chemical calculations revealed that the optimal structure of the chloroperoxyl radical is much more thermodynamically stable than that of the chlorine dioxide radical. The UV-visible spectrum of the chloroperoxyl radical showed maximum absorbance at 354 nm. This absorbance had a linear relationship with the chloroperoxyl radical ESR signal intensity. Quantifying the free chlorine concentration by the DPD method also revealed a linear relationship with the maximum absorbance at 354 nm, which in turn showed a linear relationship with the chloroperoxyl radical ESR signal intensity. These linear relationships suggest that the DPD method can quantify chloroperoxyl radicals, which this study considers to be the active species in ASC aqueous solution.

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“…In addition, the amount of newly observed NO 3 – ions was very small, suggesting that ClO 2 – ions were much less oxidative and bactericidal than ClO – ions (Figures S5–S8). , …”

Section: Resultsmentioning

confidence: 99%

“…− ions was very small, suggesting that ClO 2 − ions were much less oxidative and bactericidal than ClO − ions (Figures S5−S8). 47,48 ■ CONCLUSIONS In Mikawa Bay and Ise Bay, red tides and blue tides occurred frequently due to the industrialization of the surrounding areas, causing damage to fisheries in the same way as global warming. Due to the purification of Aburagafuchi-lake, the outflow of phytoplankton and nutrients from the surrounding waters into the closed sea area has decreased dramatically, resulting in oligotrophication in the closed sea area and impact of the ecosystem.…”

Section: Elucidation Of the Generation Mechanism Of Active Radicals B...mentioning

confidence: 99%

Elucidation of the Mechanism of Greenhouse Gas Generation by Abiotic Transformation of Nutrient Ions Flowing into Closed Water Areas with Little Phytoplankton

Noda,

Asada,

Nagao

2024

ACS EST Water

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In Mikawa Bay and Ise Bay, many tidal flats, shallow areas, and seaweed beds have been lost due to land reclamation, and the pollution inflow from domestic and industrial wastewater has increased, causing environmental deterioration such as red and blue tides. To prevent their occurrence, the hyporheic zone of the brackish lake leading to these bays was dredged and covered with sand, and sewerage systems were constructed around the surrounding areas. Furthermore, the water in this lake is regularly substituted with new river water but unregulated agricultural wastewater flows into the lake. Nutrient ions from nitrogen fertilizers in this wastewater are passively decomposed and released into the atmosphere as a greenhouse gas N 2 O. We report that ClO 2 − ions, classified as disinfection byproducts detected in this water body, promote the production of • N and • NO radicals through the abiotic transformation of NH 4 NO 3 from nitrogen fertilizers in aqueous solutions. Because these radicals are highly reactive and have a small energy gap between singly occupied molecular orbital (SOMOs), they generate N 2 O through a heterogeneous coupling reaction and release N 2 O from water to the atmosphere. Abiotic transformation mechanisms of nutrient ions provide information for resolving biodiversity crises and N 2 O emissions problems associated with marine environmental restoration. KEYWORDS: *N radical, • NO radical, nitrogen cycle, ClO 2 − ion, nitrogen fertilizer, nutrient ions, greenhouse gas, N 2 O

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Chlorous acid is a more potent antibacterial agent than sodium hypochlorite against Campylobacter

Cited by 9 publications

References 16 publications

Comparative evaluation of chlorous acid and sodium hypochlorite activity against SARS-CoV-2

Comparative evaluation of chlorous acid and sodium hypochlorite activity against SARS-CoV-2

Identifying the chloroperoxyl radical in acidified sodium chlorite solution

Elucidation of the Mechanism of Greenhouse Gas Generation by Abiotic Transformation of Nutrient Ions Flowing into Closed Water Areas with Little Phytoplankton

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