Chloroquine-enhanced gene delivery mediated by carbon nanotubes

Sanz, Vanessa; Tîlmaciu, Carmen; Soula, Brigitte; Flahaut, Emmanuel; Coley, Helen M.; Silva, S. Ravi P.; McFadden, Johnjoe

doi:10.1016/j.carbon.2011.08.001

Cited by 33 publications

(33 citation statements)

References 38 publications

(37 reference statements)

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“…It is very soluble in water with the solubility up to 1 mg/ml. 14,33 However, the nature of PDMAEA-LPMSN that can PDMAEA-LPMSN were similar, around 1200 µg/ml, which can be explained by the very low toxicity of PDMAEA 23,24 and unmodified LPMSN. 15 Similar to PDMAEA-LPMSN, Chl-PDMAEA-LPMSN did not affect the cell viability.…”

Section: 12mentioning

confidence: 95%

Functionalized large pore mesoporous silica nanoparticles for gene delivery featuring controlled release and co-delivery

et al. 2014

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Section: 12mentioning

confidence: 95%

Functionalized large pore mesoporous silica nanoparticles for gene delivery featuring controlled release and co-delivery

et al. 2014

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“…The binding ratio of the acid-treated SWCNTs and DNA was calculated to be 3:1 (DNA/SWCNTs) from the phosphorous content in DNA-SWCNTs [31]. In context of the enhanced gene delivery Sanz and co-workers were first to develop and demonstrate the enhanced gene delivery using lysosomotropic anti-malarial drug chloroquine loaded polyethyleneimine (PEI)-coated DWCNTs to enhance the cell transfection efficiency [32].…”

Section: Gene Therapymentioning

confidence: 99%

Pharmaceutical and biomedical applications of surface engineered carbon nanotubes

Mehra

Jain

2015

Drug Discovery Today

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Surface engineered carbon nanotubes (CNTs) are attracting recent attention of scientists owing to their vivid biomedical and pharmaceutical applications. The focus of this review is to highlight the important role of surface engineered CNTs in the highly challenging but rewarding area of nanotechnology. The major strength of this review lies in highlighting the exciting applications of CNTs to boost the research efforts, which unfortunately are otherwise scattered in the literature making the reading non-coherent and non-homogeneous.

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“…The molecules used for targeting of course strongly depend on the goal to achieve. Examples include proteins [239], peptides [240,241], polysaccharides [242], DNA [243], or polymers [244].…”

Section: Biofunctionalizationmentioning

confidence: 99%

“…CNTs are also flexible structures which might bend, thus allowing the interaction of functionalized CNTs with cells through multiple binding sites. Furthermore, it is also possible to take advantage of their tubular shape to simultaneously encapsulate a chosen biomedical payload in their hollow core while the external walls can be functionalized to render them dispersible, biocompatible, and even engineered for specific targets [244].…”

Section: Positive Bioproperties (Biomedical Applications)mentioning

confidence: 99%