Chloromethylated Activated Carbon: A Useful New Synthon for Making a Novel Class of Sorbents for Heavy Metal Separations

Samuels, William D.; LaFemina, Nikki H.; Sukwarotwat, Vichaya; Yantasee, Wassana; Li, Xiaohong S.; Fryxell, Glen E.

doi:10.1080/01496390903423550

Cited by 12 publications

(9 citation statements)

References 25 publications

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“…Previous work has shown that thiol-SAMMS has a high affinity for Hg, Cd, and Pb in natural waters, with K d values in excess of 10 4 and occasionally exceeding 10 6 (81). Inspection of the data in Table 4 shows that K d values are smaller in biological matrices than in natural waters.…”

Section: Resultsmentioning

confidence: 99%

Functionalized Nanoporous Silica for the Removal of Heavy Metals from Biological Systems: Adsorption and Application

Yantasee

Rutledge

Chouyyok

et al. 2010

ACS Appl. Mater. Interfaces

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122

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Surface-functionalized nanoporous silica, often referred to as self-assembled monolayers on mesoporous supports (SAMMS), has previously demonstrated the ability to serve as very effective heavy metal sorbents in a range of aquatic and environmental systems, suggesting that they may be advantageously utilized for biomedical applications such as chelation therapy. Herein we evaluate surface chemistries for heavy metal capture from biological fluids, various facets of the materials’ biocompatibility, and the suitability of these materials as potential therapeutics. Of the materials tested, thiol-functionalized SAMMS proved most capable of removing selected heavy metals from biological solutions (i.e., blood, urine, etc.) Consequentially, thiol-functionalized SAMMS was further analyzed to assess the material’s performance under a number of different biologically relevant conditions (i.e., variable pH and ionic strength) to gauge any potentially negative effects resulting from interaction with the sorbent, such as cellular toxicity or the removal of essential minerals. Additionally, cellular uptake studies demonstrated no cell membrane permeation by the silica-based materials generally highlighting their ability to remain cellularly inert and thus nontoxic. The results show that organic ligand functionalized nanoporous silica could be a valuable material for a range of detoxification therapies and potentially other biomedical applications.

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Section: Resultsmentioning

confidence: 99%

Functionalized Nanoporous Silica for the Removal of Heavy Metals from Biological Systems: Adsorption and Application

Yantasee

Rutledge

Chouyyok

et al. 2010

ACS Appl. Mater. Interfaces

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122

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“…Görüldüğü gibi sayısız çoklukta madde sentezlenebilir ve katı faz özütleyici olarak kullanılabilir [38]…”

Section: Katı Faz öZütleme Yöntemiunclassified

“…Görüldüğü gibi sayısız çoklukta madde sentezlenebilir ve katı faz özütleyici olarak kullanılabilir [38]. Son yıllarda katı faz özütleyici olarak nano boyuttaki katı malzemeler iyi tanecik boyutu ve kimyasal aktiviteleri gibi gelişmiş kendine özgü özellikleri nedeniyle giderek artan bir önem kazanmaktadır.…”

Section: Katı Faz öZütleme Yöntemiunclassified

A review on the usability of graphene/graphene oxide based sorbents in solid phase extraction technique

Canlıdinç¹

2020

Pamukkale J Eng Sci

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Bazı metallere canlı organizmaların düzenli fonksiyonlarında çok az miktarda da olsa ihtiyaç duyulmakta bu nedenle bu metallerin varlığı önem kazanmaktadır (bakır, çinko, demir, vb. gibi). Fakat bazıları zehirli olup bu zehirli metaller insanların yaşadığı çevre ve yiyecekler için tehlikeli eser metaller olarak kabul edilmektedir. Bu metaller (kurşun, cıva, kadmiyum, arsenik, çinko, demir, bakır, mangan, krom) yüksek derişimlerde zehirli bileşenlerine dönüşmesi nedeniyle zararlı olabilmektedir. Bu nedenle modern analitik kimyada, eser metallerin tayini için basit, çevre için güvenli, duyarlı ve seçici yöntemlerin geliştirilmesine doğru bir eğilim vardır. Eser metallerin düşük derişimleri nedeniyle genellikle bir ayırma ve zenginleştirme tekniği gerekmektedir. Bu tekniklerden en yaygın olarak kullanılanlardan birisi de katı faz özütleme (SPE) tekniğidir. Katı faz özütleme alanındaki yeni çalışmalar, asit ve bazlara dayanıklılık, analite seçicilik, geniş yüzey alanı ve yüksek adsorpsiyon kapasitesi gibi iyi performanslı yeni katı fazların sentezlenmesiyle ilgilidir. Grafen (G) ve grafen oksit (GO)'in maksimum adsorpsiyon kapasiteleri şimdiye kadar rapor edilenlere göre çok daha yüksek olması nedeni ile G ve GO nanotabakaları hem organik bileşikler hem de metal türler için klasik SPE'de başarılı bir şekilde uygulanabilmektedir. Some metals are needed in the regular functions of living organisms, albeit in very small amounts, so the presence of these metals becomes important (such as copper, zinc, iron, etc.). However, some of them are toxic and these toxic metals are accepted as dangerous trace metals for the environment and food in which people live. These metals (lead, mercury, cadmium, arsenic, zinc, iron, copper, manganese, chromium) can be harmful due to their conversion to toxic components at high concentrations. Therefore, in modern analytical chemistry there is a tendency to develop simple, environmentally safe, sensitive and selective methods for the determination of trace metals. Due to the low concentration of trace metals, a separation and preconcentration technique is often required. One of the most commonly used techniques is the solid phase extraction (SPE) technique. Recent tendency in the field of solid phase extraction is related to synthesis of the new sorbent materials with good performance, such as high resistance to acids and bases, selective for analytes, large surface area and high adsorption capacity. Because of the maximum adsorption capacities of graphene (G) and graphene oxide (GO) are much higher than those of the recently reported sorbents, G and GO nanosheets can be used in classical SPE of both organic compounds and metal species, with successfully.

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“…However, these chelation agents still have many disadvantages and low efficacy. They are also not effective in removing Cd and toxic anions such as chromate and arsenate [11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Complexation Behaviour of Chloroquine towards Ti (II) Ion

Otuokere

Okpara

Amadi

et al. 2019

JPRI

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Aims: Chloroquine is a member of the drug class 4-aminoquinoline used for the prevention and treatment of malaria in areas where malaria is known to be sensitive to its effects. Our aim is to synthesize the chloroquine – titanium complex and to study its coordination behavior. Place and Duration of Study: Department of Chemistry, Michael Okpara University of Agriculture, Umudike, 2019. Methodology: Ti(II) complex of chloroquine was synthesized by the reaction of chloroquine phosphate with titanium(IV) oxide. The metal complex was characterized based on UV, IR and 1H NMR Spectroscopy. Results: The UV spectrum of the complex suggested intra ligand charge transfer (ILCT), ligand to metal charge transfer (LMCT), and d-d transition. The IR spectrum of the complex showed the involvement of amine and imine group in coordination to Ti. This showed that chloroquine acted as a bidentate ligand. 1H NMR of the spectrum further showed the involvement of the amine group in coordination. Conclusion: The ability of chloroquine to sequestrate Ti (II) ion has been assured. This drug can be used to chelate Ti ions from solution, environment, and biological system.

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Chloromethylated Activated Carbon: A Useful New Synthon for Making a Novel Class of Sorbents for Heavy Metal Separations

Cited by 12 publications

References 25 publications

Functionalized Nanoporous Silica for the Removal of Heavy Metals from Biological Systems: Adsorption and Application

Functionalized Nanoporous Silica for the Removal of Heavy Metals from Biological Systems: Adsorption and Application

A review on the usability of graphene/graphene oxide based sorbents in solid phase extraction technique

Synthesis, Characterization and Complexation Behaviour of Chloroquine towards Ti (II) Ion

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