Chlorogenic acid is a positive regulator of MDA5, TLR7 and NF-κB signaling pathways mediated antiviral responses against Gammacoronavirus infection

Abaidullah, Muhammad; Peng, Shuwei; Song, Xu; Zou, Yuanfeng; Li, Lixia; Jia, Renyong; Yin, Zhongqiong

doi:10.1016/j.intimp.2021.107671

Cited by 24 publications

(18 citation statements)

References 80 publications

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“…This is in agreement with the conclusions of many studies that CGA has anti-inflammatory activities [ 36 , 37 ]. Supplemental CGA in the feed exhibited significant anti-inflammatory effects by decreasing the expression of IL-1β and TNF-α in heat-stressed broilers [ 12 ], in broilers infected with Clostridium perfringens type A [ 26 ], and in IBV-infected chickens [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Dietary Chlorogenic Acid on Growth Performance, Antioxidant Function, and Immune Response of Broiler Breeders under Immune Stress and Stocking Density Stress

Bai

Liu

et al. 2022

Veterinary Sciences

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The study was conducted to evaluate the effects of dietary chlorogenic acid supplementation on the growth performance, antioxidant function, and immune response of broiler breeders exposed to immune stress or high stocking density stress. The test was divided into two stress models. For the immune stress test, 198 birds were distributed into three experimental treatments with six replicates per treatment. The treatments were: (1) saline control (birds injected with saline and fed basal diet), (2) LPS group (birds injected with 0.5 mg LPS/kg body weight and fed basal diet), and (3) CGA + LPS group (birds injected with LPS and fed basal diet supplemented with 1 g/kg CGA. LPS was intraperitoneally injected from day 14, and then daily for 10 days. For the high stocking density stress model, 174 birds were distributed into three experimental treatments with six replicates per treatment. The treatments were: (1) controls (birds fed basal diet and raised at a stocking density of 14 broilers per m2), (2) high-density group (birds fed with basal diet and raised at a stocking density of 22 broilers per m2), and (3) high density + CGA group (birds fed with 1 g/kg CGA and raised at a stocking density of 22 broilers per m2). Results showed that LPS injection and high stocking density significantly decreased the body weight and feed intake of broiler breeders, while CGA supplementation increased feed intake of broiler breeders under LPS injection and high stocking density stress. Moreover, LPS injection and high stocking density increased the concentration of corticosterone in serum, and CGA addition remarkably downregulated serum corticosterone levels. The GSH level decreased with LPS injection and CGA increased the GSH concentration in the intestines of immune-stressed broiler breeders. LPS injection promoted the production of circulating proinflammatory cytokines (serum IL-1β and TNF-α) by 72 h after LPS injection. Dietary supplementation with CGA prevented the increase in serum TNF-α caused by LPS. These results suggest that dietary inclusion of 1 g/kg CGA could increase the feed intake of broiler breeders and alleviate the effects of inflammatory mediator stress and exposure to high stocking density.

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Section: Discussionmentioning

confidence: 99%

Effect of Dietary Chlorogenic Acid on Growth Performance, Antioxidant Function, and Immune Response of Broiler Breeders under Immune Stress and Stocking Density Stress

Bai

Liu

et al. 2022

Veterinary Sciences

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“…Chlorogenic acid significantly reduces NF-κB expression. This caused the reduction of PICs such as IL-12 and the increase of AICs such as IL-10 and IL-22, the latter also considered as PIC ( Abaidullah et al, 2021 ). In mice, catechin ingestion induced inhibition of PI3K/AKT/mTOR signaling and increased T lymphocytes.…”

Section: Methodsmentioning

confidence: 99%

Phenolic compounds versus SARS-CoV-2: An update on the main findings against COVID-19

Tirado-Kulieva¹,

Hernández-Martínez

Rivera³

2022

Heliyon

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“…In addition, high doses of CA significantly promoted CD3+, CD4+, and CD4+ / CD8 + cell proliferation and significantly increased serum of IgG, IgA, and IgM levels. According to these findings, CA is a potent anti-IBV agent that, at high concentrations, strongly regulates innate immunity via the TLR7, NF-κB, and MDA5 signaling pathways, potentially triggering both a humoral and cellmediated immune response in IBV-infected chickens [52].…”

Section: Antiviral Effect Of Ca Against Infectious Bronchitis Virus (...mentioning

confidence: 97%

Antiviral and Anti-SARS-CoV-2 Activity of Natural Chlorogenic Acid and Its Synthetic Derivatives

Aljehany¹

2022

Arch Pharm Pract

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Since the dawn of time, several viral epidemics have swept the globe, among them the current COVID-19 outbreak. The ongoing emergence and propagation of novel viral illnesses have compelled researchers to seek new therapeutic approaches that can get beyond the drawbacks of antivirals that are available right now. Medicinal plants have historically offered treatments for a range of illnesses. These bioactive compounds serve as the foundation for many "modern" pharmaceuticals. One of the essential polyphenols in various medicinal plants is Chlorogenic acid (CA), an ester of caffeic and quinic acid. Extensive research has revealed that CA possesses anti-inflammatory, anticarcinogenic, and antioxidant properties. This review aims to briefly summarise CA and its derivative's antiviral properties on various human viral diseases and their ability to fight the current COVID-19 disease. This review summarises CA antiviral action on the following viruses: influenza A virus (H1N1/H3N2/H7N9), hepatitis C virus (HCV) and hepatitis B virus (HBV), human immunodeficiency virus (HIV), infectious bronchitis virus (IBV), porcine reproductive and respiratory syndrome virus (PRRSV), herpes simplex virus (HSV)-1, enterovirus 71 (Ent 71), adenoviruses (AdenV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This review will open the way for developing and designing potentially effective and broad-spectrum CA-based antiviral medicines.

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Chlorogenic acid is a positive regulator of MDA5, TLR7 and NF-κB signaling pathways mediated antiviral responses against Gammacoronavirus infection

Cited by 24 publications

References 80 publications

Effect of Dietary Chlorogenic Acid on Growth Performance, Antioxidant Function, and Immune Response of Broiler Breeders under Immune Stress and Stocking Density Stress

Effect of Dietary Chlorogenic Acid on Growth Performance, Antioxidant Function, and Immune Response of Broiler Breeders under Immune Stress and Stocking Density Stress

Phenolic compounds versus SARS-CoV-2: An update on the main findings against COVID-19

Antiviral and Anti-SARS-CoV-2 Activity of Natural Chlorogenic Acid and Its Synthetic Derivatives

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