Chlorogenic acid ameliorates Klebsiella pneumoniae-induced pneumonia in immunosuppressed mice via inhibiting the activation of NLRP3 inflammasomes

Abstract

Chlorogenic acid (CGA) possesses a wide variety of bioactive properties, such as antioxidation, anti-inflammation and anti-bacteria. This study was aimed at exploring the effects of CGA of anti-inflammation and anti-bacteria...

Determination of six core components from Mahuang Xuanfei Zhike syrup in rat plasma and tissues by UPLC–MS/MS: Application to a pharmacokinetics and tissue distribution study

“…Among them, there were 377 intersecting targets. Taking the therapeutic effect of active ingredients on phlegm, cough and asthma as the primary reference standard and the position of active ingredients in drugs as the secondary standard, literature research was carried out, and finally six main quality control index components of MXZ syrup were selected, including ephedrine (Wang et al, 2022; Wei et al, 2019), chlorogenic acid (Li et al, 2021; Zeng et al, 2021), amygdalin (Tang et al, 2019; Wang et al, 2019), harpagoside (Zhang et al, 2017) and forsythin (Coon et al, 2014) and forsythoside A (Zheng et al, 2019). According to the order of degree value, SRC, HSP90AA1, PTPN11, CTNNB1, EP300, ESR1, F2, PIK3R1, ITGB3 and CREBBP were considered as the top 10 core targets.…”

The combination of sodium alginate and chlorogenic acid enhances the therapeutic effect on ulcerative colitis by the regulation of inflammation and the intestinal flora

“…75 CA has been reported to inhibit Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) activation, thus inhibiting the production of NO and IL-1β in the LPS-induced RAW 264.7 murine macrophages. 76,77 Liu et al found that chlorogenic acid, rosmarinic acid and isofraxidin extracted from Sarcandra glabra could decrease the secretion of NO, IL-6, and TNF-α in LPS-treated RAW264.7 macrophage cells. 78 Fang et al found that alginate-derived guluronate oligosaccharide significantly suppressed inducible nitric oxide synthase (iNOS) expression, NO release and TNF-α secretion in LPS-induced RAW264.7 macrophages.…”

Traditional Chinese Medicine Compounds Containing Lonicera japonica, Chrysanthemum morifolium, and Siraitia grosvenorii Inhibits the Growth of Streptococcus mutans

“…A previous study has reported that two active substances obtained from flowers of Lonicera japonica , 7-acetyl-8,9-dihydroxy thymol, and 7,8-dihydroxy-9-buyryl thymol play antibacterial effects on Staphylococcus aureus , Escherichia coli , Micrococcus luteus , and Bacillus cereus [ 26 , 27 ]. Chrysanthemum morifolium extract represses the growth of different intestinal pathogenic bacteria, such as Enterobacter , Enterococcus , Clostridium , and Bacteroides [ 28 ].…”