Chemical spray parameters, including temperature, pressure and exposure time, were evaluated for their effects on reducing Salmonella typhimurium on chicken skins. Pre-chilled chicken carcass skins were inoculated with S. typhimurium and sprayed with 0.1% cetylpyridinium chloride (CPC), 10% trisodium phosphate (TSP), or 2% lactic acid (LA). In the CPC spray, the 40ЊC treatments resulted in the greatest bacterial reduction. The most effective spray temperatures for LA and TSP treatments were 40 to 55ЊC. All chemical spray treatments at 207-1034 kPa reduced S. typhimurium. The reduction of S. typhimurium was greatest in all treatments when sprayed with 90 sec spray and 90 sec setting time.