Chlorination of Calix[4]arene Derivatives

Ivanova, E. A.; Prokhorova, P. E.; Mitin, V. V.; Глухарева, Т. В.; Morzherin, Yu. Yu.

doi:10.1080/00397911.2015.1036452

Cited by 1 publication

(2 citation statements)

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“…In last decades, it has been seen that a well‐recognized direct C−H functionalization reactions [14] is a convenient way to introduce various functionalities into the upper rim of calixarene core in terms of atom‐economy / atom‐efficiency. Below in Table 1, we have shown the most typical examples of C−H functionalization of calix[4]arenes at the upper rim [15–26] …”

Section: Upper Rim Direct C‐h Functionalizationmentioning

confidence: 99%

“…Below in Table 1, we have shown the most typical examples of CÀ H functionalization of calix [4]arenes at the upper rim. [15][16][17][18][19][20][21][22][23][24][25][26] Among the above reported derivatives (Table 1) in last two decades the para-sulfonato-calix [4]arenes (Table 1, entry 11) were found to possess highly diverse biomedical applications, [27] such as anti-HIV and anti-herpes activity, [28] antibacterial activity, [29] anti-thrombotic activities, [30] enzyme inhibiting activity, [31] ion-channel blocking activity, [32] and some other…”

Section: Direct C-h Functionalization At Para-positionmentioning

confidence: 99%

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Direct C−H Functionalization of Calix[n](het)arenes (n=4,6): A Brief Update

et al. 2022

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Calix[4]arenes are, probably, the mostly explored macrocycles in the supramolecular chemistry. By means of the synthetic modification/functionalization of the upper or lower rims, as well as meso‐positions, the “host‐guest” properties of these macrocycles can be modulated in order to accommodate the guest molecules of various sizes and nature for supramolecular and coordination chemistry, and to perform various functions for materials science and for biomedical applications. In this review, we wish to highlight the most prospective synthetic approaches for the direct C−H functionalization of calixarene core with various functional moieties. Depending on the nature of the functional moiety these calix[4]arenes can serve as drug carriers and nano‐containers for the recognition, encapsulation or storage of bioactive molecules and for many other applications. Current review article deals with the recent examples of C(H)‐functionalization of calix[4]arenes, as well as selected patterns of direct C(H)‐modification of some calix[6]arenes and calix[4]pyrroles.

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Section: Upper Rim Direct C‐h Functionalizationmentioning

confidence: 99%