Chlorinated pesticides and cancer of the head and neck

Govett, Gregg; Genuis, Stephen J.; Govett, Hannah E.; Beesoon, Sanjay

doi:10.1097/cej.0b013e328345f971

Cited by 8 publications

(6 citation statements)

References 21 publications

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“…In this respect, the use of various pesticides canresult into wide range of human diseases and adversely impact the health and quality of life of humans (Nasterlack, 2001). Recent reports have revealed that pesticides may cause liver, pancreas, brain, prostate and other cancers due to their inherent toxicity in human (Koutros et al, 2013;Boada et al, 2012;Liu, 2012;Giannandrea, 2012;Govett et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

In Silico Prediction of the Mitigative Potential of Curcumin Against Deltamethrin Toxicity

Patel¹,

Patel²,

Pandya³

et al. 2022

IABCD

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Deltamethrin (DLM) is a widely used pyrethroid, pest control insecticide due to restriction on the sale of organophosphate. Deltamethrin (DLM) being a potent hepatotoxic compound, that affects physiological functions of liver; however, the implications of the hepatotoxic effects of DLM on the mammalian system and its influence on the hepatic enzymatic activity are still unclear. Curcumin (CUR), a major polyphenol component of Curcuma longa Linn, is a potent antioxidant often used in traditional medicine as an ameliorative agent. However, its underlying mechanism as an anti-oxidant against DLM-toxicity remains unknown. Hence, the present study has been designed to determine the binding affinity of DLM to a hepatic enzyme marker such as Aspartate aminotransferase (AST). Moreover, the study is aimed to delineate the role of CUR on DLM-induced hepatotoxic effects through a computational approach. The molecular docking carried out demonstrated that CUR manifests a stronger binding affinity towards the liver marker enzyme, AST as compared to deltamethrin. This could explain the possible mechanism for inhibition of the toxic influence of DLM- induced reactive oxygen species on liver enzyme activity. Thus, this computational evidence validates the tenet that CUR displays anti-oxidative properties for attenuation of DLM induced hepatotoxicity, alteration in the mechanism of liver marker enzyme and its subsequent impact on hepatic tissue.

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Section: Introductionmentioning

confidence: 99%

In Silico Prediction of the Mitigative Potential of Curcumin Against Deltamethrin Toxicity

Patel¹,

Patel²,

Pandya³

et al. 2022

IABCD

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“…Some studies suggest that contamination with chlorinated pesticides can be related to neurodegenerative diseases and cancers and contribute to the development of type 2 diabetes mellitus (T2D), due to the interference in glucose uptake and adiposity function, resulting in proinflammatory responses and disrupted energy metabolism [ 9 , 10 , 11 ]. These substances can follow the transplacental route, and be transferred through lactation; therefore, individuals can be exposed to these compounds before birth and in early childhood [ 10 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Agrochemical Residues in Fish and Bivalves from Sepetiba Bay and Parnaiba River Delta, Brazil

Miranda

Fogaça

Cunha

et al. 2022

IJERPH

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Accumulation of pesticides has a harmful impact on the environment and human health. The main goal of this work was to develop a method to determine and quantify the residues of thirteen pesticides in edible fish and bivalves such as parati (Mugil curema), seabass (Centropomus ssp.), mullet (Mugil brasiliensis), clams (Anomalocardia brasiliana) and mussel (Mytilus galloprovincialis) collected from Sepetiba Bay and Parnaiba River Delta (Brazil) between 2019 and 2020. Matrix solid-phase dispersion (MSPD) was used for extraction and quantification through gas chromatography coupled to tandem mass spectrometry (GC-MS/MS). The method was validated (linearity, accuracy and precision) for fatty fish (Salmo salar), lean fish (Mugil curema) and bivalves (Mytilus edulis). The survey found linear correlation coefficients (r) equal to or greater than 0.9 for almost all analytes. The relative standard deviations (RSD) of five replicates were less than 20% for almost all analytes at different concentrations in lean fish, fatty fish and bivalves. Most analytes showed satisfactory accuracy. Alachlor herbicide was found in samples of seabass, mussels, clams and parati with levels ranging between 0.55 to 420.39 μg kg−1 dw. Ethion was found in parati (maximum 211.22 μg kg−1 dw), mussels (15.1 μg kg−1 dw) and clams (maximum 44.50 μg kg−1 dw). Alachlor was found in clams (maximum 93.1 μg kg−1 dw), and bifenthrin was found in parati (maximum 43.4 μg kg−1 dw) and clams (maximum 42.21 μg kg−1 dw). The validated method was satisfactory for the determination of eleven pesticides in the fatty fish matrix, and thirteen pesticides in the samples of lean fish and bivalves. The presence of alachlor, ethion and bifenthrin stands out.

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“…hepatocellular carcinoma (Zhao et al, 2011), breast cancer (Salehi et al, 2008), cancer of the head and neck (Govett et al, 2011), non-Hodgkin lymphoma (Engel et al, 2007), prostate cancer (Xu et al, 2010), testicular germ cell tumors (McGlynn et al, 2008), or pancreatic cancer (Hardell et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

“…However, there have been conflicting reports on the relationship between exposure to low levels of POPs, such as those occurring in the general population, and cancer risk, with some studies reporting positive associations but many others finding no evidence to support a causal association (Cassidy et al, 2005;Charlier et al, 2003;Cohn et al, 2010;Gatto et al, 2007;Govett et al, 2011;Hardell et al, 2006;Hoyer et al, 2001;Laden et al, 2001;Lopez-Carrillo et al, 2002;Lopez-Cervantes et al, 2004;Mozzachio et al, 2008;Pavuk et al, 2004;Recio-Vega et al, 2011;Snedeker, 2001;Soto and Sonnenschein, 2010;Svensson et al, 1995;Ward et al, 2000;Wolff et al, 2000;Xu et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Adipose tissue concentrations of persistent organic pollutants and total cancer risk in an adult cohort from Southern Spain: Preliminary data from year 9 of the follow-up

Arrebola

Fernández

Martín‐Olmedo

et al. 2014

Science of The Total Environment

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There is an increasing trend in the incidence of cancer worldwide, and it has been accepted that environmental factors account for an important proportion of the global burden. The present paper reports preliminary findings on the influence of the historical exposure to a group of persistent organic pollutants on total cancer risk, at year 9 in the follow-up of a cohort from Southern Spain.A cohort of 368 participants (median age 51 yrs) was recruited in 2003. Their historical exposure was estimated by analyzing residues of persistent organic pollutants in adipose tissue. Estimation of cancer incidence was based on data from a population-based cancer registry. Statistical analyses were performed using multivariable Cox-regression models.In males, PCB 153 concentrations were positively associated with total cancer risk, with an adjusted hazard ratio (95% confidence interval) of 1.20 (1.01-1.41) for an increment of 100 ng/g lipid.Our preliminary findings suggest a potential relationship between the historical exposure to persistent organic pollutants and the risk of cancer in men. However, these results should be interpreted with caution and require verification during the future follow-up of this cohort.

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Chlorinated pesticides and cancer of the head and neck

Cited by 8 publications

References 21 publications

In Silico Prediction of the Mitigative Potential of Curcumin Against Deltamethrin Toxicity

In Silico Prediction of the Mitigative Potential of Curcumin Against Deltamethrin Toxicity

Agrochemical Residues in Fish and Bivalves from Sepetiba Bay and Parnaiba River Delta, Brazil

Adipose tissue concentrations of persistent organic pollutants and total cancer risk in an adult cohort from Southern Spain: Preliminary data from year 9 of the follow-up

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