Chlorin e6 decorated doxorubicin encapsulated chitosan nanoparticles for photo-controlled cancer drug delivery

Bhatta, Anindita; Krishnamoorthy, Gurumoorthy; Nidhin, Marimuthu; Dihingia, Anjum; Manna, Prasenjit; Biswal, Himadree T.; Das, Minati; Krishnamoorthy, G.

doi:10.1016/j.ijbiomac.2019.06.127

Cited by 35 publications

(16 citation statements)

References 51 publications

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“…NPCH-TQ showed a triphasic release profile with a maximum release of 62% at 28 days. The insolubility of TQ in water results in a slow burst release and diffusion phase showing a slower release profile than other water-soluble drugs such as doxorubicin encapsulated in chitosan nanoparticles, which reached 100% of release at 170 h [34]. Another work in which TQ was encapsulated in pegylated polylactide co-glycolide nanoparticles (TF-PEG-PLGA-TQ NPs) for the treatment of non-small cell lung carcinoma achieved a maximum of 50% cumulative release of TQ in 24 h at pH 7.4, showing a faster release than NPCH-TQ due to the more hydrophilic nature of PEG-PLGA, facilitating the release of the hydrophobic compound from raw materials [35].…”

Section: Discussionmentioning

confidence: 99%

Thymoquinone-Loaded Chitosan Nanoparticles as Natural Preservative Agent in Cosmetic Products

Mondéjar-López

López-Jiménez

Garcı́a-Martı́nez

et al. 2022

IJMS

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The current status of controversy regarding the use of certain preservatives in cosmetic products makes it necessary to seek new ecological alternatives that are free of adverse effects on users. In our study, the natural terpene thymoquinone was encapsulated in chitosan nanoparticles. The nanoparticles were characterized by DLS and TEM, showing a particle size of 20 nm. The chemical structure, thermal properties, and release profile of thymoquinone were evaluated and showed a successful stabilization and sustained release of terpenes. The antimicrobial properties of the nanoparticles were evaluated against typical microbial contaminants found in cosmetic products, showing high antimicrobial properties. Furthermore, natural moisturizing cream inoculated with the aforementioned microorganisms was formulated with thymoquinone-chitosan nanoparticles to evaluate the preservative efficiency, indicating its promising use as a preservative in cosmetics.

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Section: Discussionmentioning

confidence: 99%

Thymoquinone-Loaded Chitosan Nanoparticles as Natural Preservative Agent in Cosmetic Products

Mondéjar-López

López-Jiménez

Garcı́a-Martı́nez

et al. 2022

IJMS

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“…As for a photo-controlled DDS used for cancer treatment, Bhatta et al [159] have reported the physico-chemical, photophysical, and morphological properties of chlorin e6 (Ce6) decorated doxorubicin (DOX) encapsulated chitosan/TPP NPs prepared by an ionotropic gelation method. The NPs showed high encapsulation efficiency towards DOX as well as pH-controlled release.…”

Section: Stimuli Responsive Chitosan Chitosan Nanoparticles and Nanocompositesmentioning

confidence: 99%

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Mikušová

Mikuš

2021

IJMS

234

120

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Nanoparticles (NPs) have an outstanding position in pharmaceutical, biological, and medical disciplines. Polymeric NPs based on chitosan (CS) can act as excellent drug carriers because of some intrinsic beneficial properties including biocompatibility, biodegradability, non-toxicity, bioactivity, easy preparation, and targeting specificity. Drug transport and release from CS-based particulate systems depend on the extent of cross-linking, morphology, size, and density of the particulate system, as well as physicochemical properties of the drug. All these aspects have to be considered when developing new CS-based NPs as potential drug delivery systems. This comprehensive review is summarizing and discussing recent advances in CS-based NPs being developed and examined for drug delivery. From this point of view, an enhancement of CS properties by its modification is presented. An enhancement in drug delivery by CS NPs is discussed in detail focusing on (i) a brief summarization of basic characteristics of CS NPs, (ii) a categorization of preparation procedures used for CS NPs involving also recent improvements in production schemes of conventional as well as novel CS NPs, (iii) a categorization and evaluation of CS-based-nanocomposites involving their production schemes with organic polymers and inorganic material, and (iv) very recent implementations of CS NPs and nanocomposites in drug delivery.

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“…It is a type of porphyrin that has properties of high sensitization with the capability to produce ROS ( Rengeng et al, 2017 ). Ce6 is reported to be activated by light/ultrasound and can inhibit the growth of tumor cells ( Li et al, 2014 ; Bhatta et al, 2019 ). However, Ce6 has a property of hydrophobicity in the water environment, and since it gathers into a bigger crystal, it gets harder for it to function completely ( Liu et al, 2017 ; Zhang et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Biomimetic Metal-Organic Framework Nanoparticles for Synergistic Combining of SDT-Chemotherapy Induce Pyroptosis in Gastric Cancer

Zhu

Cao

Han

et al. 2022

Front. Bioeng. Biotechnol.

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In recent years, sonodynamic therapy (SDT) has been widely developed for cancer research as a promising non-invasive therapeutic strategy. Here, we synthesized zeolitic imidazole frameworks-8 (ZIF-8) and utilized its properties to encapsulate hydrophobic Chlorin e6 (Ce6) and hydrophilic tirapazamine (TPZ) for a synergistic sonodynamic chemotherapy, which was also accompanied by the modification of cytomembrane of gastric cancer (GC) cells. Thus, we enabled the biomimetic property to achieve targeted delivery. Ce6-mediated SDT, in combination with ultrasound irradiation, could target the release of reactive oxygen species (ROS) to aggravate further hypoxia and activate TPZ. Combining these effects could induce the pyroptosis of GC cells and play the anti-tumor function, which could provide a potential therapeutic method for cancer therapy.

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Chlorin e6 decorated doxorubicin encapsulated chitosan nanoparticles for photo-controlled cancer drug delivery

Cited by 35 publications

References 51 publications

Thymoquinone-Loaded Chitosan Nanoparticles as Natural Preservative Agent in Cosmetic Products

Thymoquinone-Loaded Chitosan Nanoparticles as Natural Preservative Agent in Cosmetic Products

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Biomimetic Metal-Organic Framework Nanoparticles for Synergistic Combining of SDT-Chemotherapy Induce Pyroptosis in Gastric Cancer

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