Biomimetic Metal-Organic Framework Nanoparticles for Synergistic Combining of SDT-Chemotherapy Induce Pyroptosis in Gastric Cancer

Zhu, Yu; Cao, Wenlong; Han, Chuangye; Wang, Zhen; Qiu, Yue; Wang, Jiancheng; Wei, Mengda; Wang, Junfu; Zhang, Siwen; Liu, Senfeng; Mo, Shutian; Chen, Junqiang

doi:10.3389/fbioe.2022.796820

Cited by 24 publications

(19 citation statements)

References 48 publications

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“…Moreover, the pyroptosis-related protein GSDMD may inhibit the cell proliferation of GC, and when GSDME is knocked down, the growth of GC cells is affected [ 132 , 133 ]. It is demonstrated that the release of ROS by sonodynamic therapy (SDT) treatment induces the pyroptosis of GC cells and plays the antitumor function [ 134 ]. It is reported that treating GC cells with famotidine triggers the activation of NLPR3 inflammasomes and leads to the mature and secretion of GSDME and IL-18, resulting in the pyroptosis of GC cells [ 135 ].…”

Section: Pyroptosis and Cancermentioning

confidence: 99%

Targeted Pyroptosis Is a Potential Therapeutic Strategy for Cancer

Qian

Bai

et al. 2022

Journal of Oncology

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As a type of regulated cell death (RCD) mode, pyroptosis plays an important role in several kinds of cancers. Pyroptosis is induced by different stimuli, whose pathways are divided into the canonical pathway and the noncanonical pathway depending on the formation of the inflammasomes. The canonical pathway is triggered by the assembly of inflammasomes, and the activation of caspase-1 and then the cleavage of effector protein gasdermin D (GSDMD) are promoted. While in the noncanonical pathway, the caspase-4/5/11 (caspase 4/5 in humans and caspase 11 in mice) directly cleave GSDMD without the assembly of inflammasomes. Pyroptosis is involved in various cancers, such as lung cancer, gastric cancer, hepatic carcinoma, breast cancer, and colorectal carcinoma. Pyroptosis in gastric cancer, hepatic carcinoma, breast cancer, and colorectal carcinoma is related to the canonical pathway, while both the canonical and noncanonical pathway participate in lung cancer. Moreover, simvastatin, metformin, and curcumin have effect on these cancers and simultaneously promote the pyroptosis of cancer cells. Accordingly, pyroptosis may be an important therapeutic target for cancer.

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Section: Pyroptosis and Cancermentioning

confidence: 99%

Targeted Pyroptosis Is a Potential Therapeutic Strategy for Cancer

Qian

Bai

et al. 2022

Journal of Oncology

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“…2 , porphyrins include hematoporphyrin (HP), protoporphyrin IX (PpIX), hematoporphyrin monomethyl ether (HMME), and chlorin e6 (Ce6). 63 As early as 1989, Yumita et al treated cell suspensions with hematoporphyrin as a sonosensitizer and then treated sarcoma cells and AH 130 cells with ultrasonic waves at a frequency of 1.92 MHz and different intensities. The results showed that HP combined with ultrasound damaged 99% and 95% of the tumor cells.…”

Section: Application Of Sonosensitizers In Sdtmentioning

confidence: 99%

Application of nanosonosensitizer materials in cancer sono-dynamic therapy

Hou

Xie

2022

RSC Adv.

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“…Another study demonstrated that ZIF-8 outperformed the extensively used antibacterial ZnO ( Ahmed et al, 2019 ). The photoelectrons trapped within the zinc ions of ZIF-8 are responsible for ROS production inducing cell deformation and cytoplasm leakage of bacteria ( Ahmed et al, 2019 ; Li et al, 2022a ; Yu et al, 2022 ). It is noteworthy that the ZIF-8 crystal exhibits excellent capabilities for drug delivery because the ZIF-8 is stable in neutral or alkaline aqueous medium but break down rapidly in acidic medium ( Liu et al, 2020a ).…”

Section: Introductionmentioning

confidence: 99%

Debridement of contaminated implants using air-polishing coupled with pH-responsive maximin H5-embedded metal-organic frameworks

Zhu

Zhi²,

Zhang³

et al. 2023

Front. Bioeng. Biotechnol.

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The primary goal of peri-implantitis treatments remains the decontamination of implant surfaces exposed to polymicrobial biofilms and renders biocompatibility. In this study, we reported a synergistic strategy for the debridement and re-osteogenesis of contaminated titanium by using erythritol air abrasion (AA) coupled with an as-synthesized pH-responsive antimicrobial agent. Here, the anionic antibacterial peptide Maximin H5 C-terminally deaminated isoform (MH5C) was introduced into the Zeolitic Imidazolate Frameworks (ZIF-8) via a one-pot synthesis process. The formed MH5C@ZIF-8 nanoparticles (NPs) not only possessed suitable stability, but also guarantee the slow-release effect of MH5C. Antibacterial experiments revealed that MH5C@ZIF-8 NPs exhibited excellent antimicrobial abilities toward pathogenic bacteria of peri-implantitis, confirming ZIF-8 NPs as efficient nanoplatforms for delivering antibacterial peptide. To evaluate the comprehensive debridement efficiency, single-species as well as mixed-species biofilms were successively established on commercially used titanium surfaces and decontaminated with different methods: removed only by erythritol air abrasion, treated merely with MH5C@ZIF-8 NPs, or received both managements. The results demonstrated that only erythritol air abrasion accompanied with MH5C@ZIF-8 NPs at high concentrations eliminated almost all retained bacteria and impeded biofilm rehabilitation, while neither erythritol air abrasion nor MH5C@ZIF-8 NPs alone could achieve this. Subsequently, we evaluated the re-osteogenesis on previously contaminated surfaces which were treated with different debridement methods afterwards. We found that cell growth and osteogenic differentiation of bone marrow–derived mesenchymal stem cells (BMSCs) in the group received both treatments (AA + MH5C@ZIF-8) were higher than those in other groups. Our work emphasized the great potential of the synergistic therapy as a credible alternative for removing microorganisms and rendering re-osseointegration on contaminated implant surfaces, boding well for the comprehensive applications in peri-implantitis treatments.

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Biomimetic Metal-Organic Framework Nanoparticles for Synergistic Combining of SDT-Chemotherapy Induce Pyroptosis in Gastric Cancer

Cited by 24 publications

References 48 publications

Targeted Pyroptosis Is a Potential Therapeutic Strategy for Cancer

Targeted Pyroptosis Is a Potential Therapeutic Strategy for Cancer

Application of nanosonosensitizer materials in cancer sono-dynamic therapy

Debridement of contaminated implants using air-polishing coupled with pH-responsive maximin H5-embedded metal-organic frameworks

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