Chloride-assisted electrochemical detection of cis-dichlorodiammineplatinum(II) after liquid chromatography

Richmond, William N.; Baldwin, Richard P.

doi:10.1016/0003-2670(83)80013-0

Cited by 24 publications

(1 citation statement)

References 15 publications

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“…A liquid chromatographic method with electrochemical detection, based on this chloride-assisted oxidation, using a platinum electrode working at +0.9 V (versus satured calomel electrode) can detect 0.05 mg/1 cisplatin in a 0.1 mol/1 C1 solution [144]. At a glassy carbon or a carbon paste electrode a potential > 1.2 V is required for cisplatin oxidation [142 145].…”

Section: Voltammetrymentioning

confidence: 99%

Platinum antitumour agents: A review of (bio)analysis

Hodes

Underberg

Los

et al. 1992

Pharmaceutisch Weekblad Scientific Edition

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This paper summarizes analytical techniques in order to get a clear picture of the ins and outs of the (bio)analysis of platinum-containing compounds. The antitumour agent cisplatin has become an indispensable drug for the cure of a variety of cancer diseases. Since its introduction in the early seventies, about 2,000 related platinum complexes were designed to devoid the dose-limiting nephrotoxicity. Some of them were introduced for clinical trial, such as carboplatin and iproplatin. To investigate the mechanism of action and pharmaco-kinetic behaviour, several interesting assays for total and specific platinum determination in biological matrices have been developed, each with its own possibilities and limitations.

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Section: Voltammetrymentioning

confidence: 99%

Platinum antitumour agents: A review of (bio)analysis

Hodes

Underberg

Los

et al. 1992

Pharmaceutisch Weekblad Scientific Edition

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Electrochemical determination of carboplatin in serum using a DNA‐modified glassy carbon electrode

et al. 1996

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An electrochemical method for the determination of the anticancer platinum drug carboplatin using a DNA-modified electrode was developed. This electrode was successfully used for the electrochemical determination of carboplatin in serum samples of patients with ovarian cancer undergoing treatment. The electrochemical results clearly demonstrated that, for low concentrations, carboplatin interacts preferentially with adenine rather than guanine groups in the DNA and they can contribute to clarifying the mechanisms of interaction of platinum anticancer drugs with DNA. The pharmacokinetics c o r m ondIng to the administration of the drug was followed electrochemically and the detection limit in serum samples was 5.7 x 10 M. Due to a similar mechanism of reaction with DNA other platinum anticancer drugs can be determined by this method.

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Voltammetric determination of platinum in drug preparations, biologically active compounds, and biological objects (a review)

Ezerskaya

1996

Pharm Chem J

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Chloride-assisted electrochemical detection of cis-dichlorodiammineplatinum(II) after liquid chromatography

Cited by 24 publications

References 15 publications

Platinum antitumour agents: A review of (bio)analysis

Platinum antitumour agents: A review of (bio)analysis

Electrochemical determination of carboplatin in serum using a DNA‐modified glassy carbon electrode

Voltammetric determination of platinum in drug preparations, biologically active compounds, and biological objects (a review)

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