Electrochemical determination of carboplatin in serum using a DNA‐modified glassy carbon electrode

Oliveira-Brett, Ana Maria; Serrano, Sı́lvia Helena Pires; Macedo, T.R.A.; Raimundo, D.; Marques, M.H.; La-Scalea, Mauro Aquiles

doi:10.1002/elan.1140081104

Cited by 102 publications

(58 citation statements)

References 27 publications

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“…The decrease observed in guanine signals in the presence of their interaction with nucleic acids was found to be similar to results presented in the literature 7,16 by using some anticancer drugs or DNA targeted compounds. Thus this result can be explained similarly to the decrease in the response of a DNA biosensor, which could be attributed to preferentially binding of these compounds to the most electroactive base of DNA, i.e., guanine in the case of an interaction with DNA at the electrode surface.…”

Section: Interaction Of Compounds With Dna At An Electrode Surfacesupporting

confidence: 89%

“…In recent years, there is a growing interest in the design of electrochemical DNA biosensors that can be used to examine the interactions between surface-modified DNA and target drugs for their rapid screening. [3][4][5][6][7][8][14][15][16][17][18][19][20][21][22][23][24] However, there is only a few data concerning electrochemical evaluations of the interactions between potential chemotherapeutic agents, anticancer compounds and other drug candidates and DNA. Data obtained include the IC50 (concentration required to inhibit the cellular growth by 50%) values of these agents or drug candidates.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Electrochemical Investigation of Interactions between Potential DNA Targeted Compounds, 2,4-Di- and 2,3,4-Trisubstituted Benzimidazo[1,2-a]pyrimidines and Nucleic Acid

et al. 2010

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The electrochemical aspects of interactions between DNA and two organic compounds are discussed herein. Potential DNA targeted compounds, 2-methyl-4-phenyl-benzo [4,5]imidazo[1,2-a]pyrimidine (c1) and 2,3,4-trimethyl-benzo[4,5]-imidazo[1,2-a]pyrimidine (c2), were synthesized and their cytotoxic and/or growth inhibitory effects were studied previously. Disposable sensor technology was used to explore the interaction between the compounds and nucleic acid, such as fish sperm DNA at the electrode surface and in the solution phase. The changes upon encountering oxidation signals of electroactive DNA base-guanine and these compounds were monitored electrochemically.

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Section: Interaction Of Compounds With Dna At An Electrode Surfacesupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Electrochemical Investigation of Interactions between Potential DNA Targeted Compounds, 2,4-Di- and 2,3,4-Trisubstituted Benzimidazo[1,2-a]pyrimidines and Nucleic Acid

et al. 2010

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“…Interactions of several substances with dsDNA have been successfully studied using a recently-developed voltammetric DNA-biosensor [12,13]. This DNA-biosensor allowed the clarification of not only the specific interaction of some drugs with a certain DNA base but also of the electrochemical mechanism of the interaction [13].…”

Section: Introductionmentioning

confidence: 99%

“…This DNA-biosensor allowed the clarification of not only the specific interaction of some drugs with a certain DNA base but also of the electrochemical mechanism of the interaction [13].…”

Section: Introductionmentioning

confidence: 99%

Anodic voltammetry and AFM imaging of picomoles of adriamycin adsorbed onto carbon surfaces

Oliveira-Brett

Piedade

Chiorcea

2002

Journal of Electroanalytical Chemistry

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Adriamycin adsorbs strongly and irreversibly onto surfaces and this enabled electrochemical detection of in situ adriamycin oxidative damage to DNA. The adsorption of adriamycin onto glassy carbon and highly oriented pyrolytic graphite (HOPG) electrodes was studied by voltammetry and mode atomic force microscopy (MAC). At a glassy carbon electrode (GCE), the adsorbate has similar voltammetric behaviour to adriamycin in solution, which enabled the cyclic, differential pulse and square wave voltammetric study of the electron transfer reaction. The total surface concentration of adriamycin adsorbed onto GCE, from a 50 nM adriamycin solution during 3 min, was calculated to be 2.57)/10 (12 mol cm (2 . The oxidation of adsorbed adriamycin is pHdependent and corresponds to a two electron/two proton mechanism, and the detection limit for adriamycin adsorbed onto the GCE was 3.33)/10 (10 M. In situ AFM images show quick and spontaneous adsorption of the adriamycin onto a HOPG surface. Adriamycin forms a stable monolayer when adsorbed from different concentrations of adriamycin solutions and for short adsorption times. The strong and irreversible chemisorption of adriamycin onto carbon electrodes enables detection limits of the order of picomolar, which is much lower than the detection limits attainable by voltammetric methods for most organic compounds. #

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“…In order to improve these characteristics the use of new materials in sensors has included many species such as metal complexes 7 , enzymes 8 and DNA 9 . These modifications consist in immobilizing some catalyst or electron mediator species to electrocatalyze the oxidation or reduction of target analytes without application of high overpotentials [7][8][9] . For this purpose, the use of Rhodium Acetamidate Modified Electrode (RAME) has been described 10 .…”

Section: Introductionmentioning

confidence: 99%

Electrochemical behavior of rhodium acetamidate immobilized on a carbon paste electrode: a hydrazine sensor

Gil¹,

Kubota²

2000

J. Braz. Chem. Soc.

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O comportamento eletroquímico do acetamidato de ródio imobilizado em pasta de carbono e as potencialidades para construção de sensores foram avaliados. O complexo imobilizado mostrou boa estabilidade e propriedades redox, sendo observados dois pares redox reversíveis com potenciais médios entre 0,15 e 0,55 V vs SCE. Entretanto, a resolução dos picos voltamétricos mostrou-se dependente do eletrólito suporte. A correlação entre a capacidade coordenante do eletrólito e seus respectivos potenciais médios sugere que o eletrólito deve coordenar-se em posição axial nos complexos. Além disto, a posição axial deve ser o sítio catalítico, sendo que a oxidação de espécies doadoras, como hidrazina, foi catalisada por estes complexos. O baixo potencial (<300 mV) mostra uma boa viabilidade deste composto para a confecção de sensores para a hidrazina, minimizando problemas de interferentes. Uma boa faixa de resposta linear para a hidrazina foi ajustada pela equação i = 23,13 (± 0,34) c , onde i = corrente em mA and c = concentração em mol dm -3 na faixa de 10 -5 a 10 -2 mol dm -3 . O baixo tempo de resposta (~1 s) poderia ser útil em análises por injeção em fluxo. Este sistema foi bem estável e apresentou boa repetibilidade, mesmo após 30 medições, com uma variância de 0,5 %.The electrochemical behavior of rhodium acetamidate immobilized in carbon paste electrode and the consequences for sensor construction were evaluated. The electrode showed good stability and redox properties. Two reversible redox couples with midpoint potentials between 0.15 and 0.55 V vs SCE were observed. However, peak resolution in voltammetric studies was very dependent on the supporting electrolyte. The correlation between coordinating power of the electrolyte and peak potential suggests that the electrolyte can coordinate through the axial position of the complexes. Furthermore, the axial position may be also the catalytic site, as a catalytical response was observed for hydrazine oxidation. A good linear response range for hydrazine was fit by the equation i = 23.13 (± 0.34) c , where i = current in mA and c = concentration in mol dm -3 in the range of 10 -5 up to 10 -2 mol dm -3 . The low applied potential (<300 mV) indicates a good device for hydrazine sensor, minimizing interference problems. The short response time (~1 s) may be useful in flow injection analysis. Furthermore, this system was very stable presenting good repeatability even after 30 measurements with a variance of 0.5 %.

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Electrochemical determination of carboplatin in serum using a DNA‐modified glassy carbon electrode

Cited by 102 publications

References 27 publications

Electrochemical Investigation of Interactions between Potential DNA Targeted Compounds, 2,4-Di- and 2,3,4-Trisubstituted Benzimidazo[1,2-a]pyrimidines and Nucleic Acid

Electrochemical Investigation of Interactions between Potential DNA Targeted Compounds, 2,4-Di- and 2,3,4-Trisubstituted Benzimidazo[1,2-a]pyrimidines and Nucleic Acid

Anodic voltammetry and AFM imaging of picomoles of adriamycin adsorbed onto carbon surfaces

Electrochemical behavior of rhodium acetamidate immobilized on a carbon paste electrode: a hydrazine sensor

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