Chlorhexidine possesses unique cytotoxic actions in rat thymic lymphocytes: Its relation with electrochemical property of membranes

Evaluation of 4 Presurgical Skin Preparation Methods in Mice

“…For example, chlorhexidine is generally safe on intact skin and requires shorter contact time than iodophores, but chlorhexidine is cytotoxic to mucous membranes and other tissues and thus might secondarily promote bacterial colonization and infection. 14,30,33,41,44,48 A complete discussion of available agents and considerations for their use is beyond the scope of the current study, and several excellent reviews are available in the human medical literature. 37 Questions regarding effectiveness and concern over potential untoward outcomes associated with surgical skin preparation have driven many discussions within the Emory University IACUC.…”