Chlorhexidine: An Adjunct to Periodontal Therapy

Greenstein, Gary; Berman, Charles L.; Jaffin, Robert A.

doi:10.1902/jop.1986.57.6.370

Cited by 167 publications

(103 citation statements)

References 64 publications

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“…CHX is a positively charged hydrophobic and lipophilic molecule that interacts with phospholipids and lipopolysaccharides in the bacterial cell membrane and enters the cell 22) . CHX gluconate is a stable watersoluble salt that readily dissociates and releases a positively charged CHX component 23) . CHX (2%) is bactericidal by precipitating cytoplasmic contents, leading to cell death 24) .…”

Section: Discussionmentioning

confidence: 99%

Antibacterial capacity of cavity disinfectants against <i>Streptococcus mutans</i> and their effects on shear bond strength of a self-etch adhesive

Cha

Shin

2016

Dent. Mater. J.

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We evaluated the antibacterial properties of three disinfectants [2% chlorhexidine (CHX), 6% sodium hypochlorite (NaOCl), and 0.01% urushiol)] against Streptococcus mutans and their effects on bond strength of Scotchbond TM Universal. The reduction in bacterial growth was evaluated by the colony counting method. Total 105 specimens were assigned to seven groups, according to surface pretreatment: control group (C) without pretreatment; chlorhexidine gluconate with rinse (CR) or without rinse (CD); NaOCl with rinse (NR) or without rinse (ND); and urushiol with rinse (UR) or without rinse (UD). The shear bond test was performed at a cross-head speed of 0.5 mm/min. None of the disinfected specimens had viable microbes after a 30 min incubation. The control group exhibited the strongest bond; however, no significant difference was detected with the disinfectant-treated groups, except weak bonding with ND group. These findings suggest that all disinfectants tested had strong antibacterial capacity and may better be rinsed away.

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Section: Discussionmentioning

confidence: 99%

Antibacterial capacity of cavity disinfectants against <i>Streptococcus mutans</i> and their effects on shear bond strength of a self-etch adhesive

Cha

Shin

2016

Dent. Mater. J.

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“…CHX is a synthetic cationic bis-guanide consists of two symmetric 4-cholorophenyl rings and two biguanide groups connected by a central hexamethylene chain. 26 There is no difference in release of mercury ions in Chlorhexidine group as compare to saline. When trying to extrapolate our results to clinical conditions, the fact that the size of the amalgam samples used in this study was larger than the usual amalgam size used to seal root perforations must be taken into consideration.…”

Section: Discussionmentioning

confidence: 84%

In Vitro Comparative Evaluation of Effect of Different Irrigating Solutions on Mercury Released From Dental Amalgam

Chandak¹,

Patidar²,

Chandak³

et al. 2014

IOSRJDMS

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“…CHX is a synthetic cationic bis-guanide, which consists of 2 similar circles of 4-chlorophenyl and two bi-guanide groups, which are connected to each other with a central chain of hexa-methylene (Greenstein et al, 1986;Barrios et al, 2013). CHX is a lipophilic and hydrophobic positively-charged molecule, which reacts with bacterial cell membrane phospholipids and lipopolysaccharides and enters the cell through a number of active and passive transport mechanisms (Athanassiadis et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

“…CHX is a base and is stable like a salt. The most commonly used oral form of CHX is its gluconate form, which is soluble in water and at physiologic pH releases positively charged CHX (Greenstein et al, 1986;Balla et al, 2013). At low concentration of 0.2%, lowmolecular-weight components such as potassium and phosphorus exit the cell.…”

Section: Discussionmentioning

confidence: 99%

Effect of adding chlorhexidine to calcium enriched mixture (CEM) on its antimicrobial activity

Froughreyhani¹,

Ghasemi²,

Safaralizadeh³

et al. 2014

Afr. J. Microbiol. Res.

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In recent years, a new endodontic cement, calcium enriched mixture (CEM) has been introduced; with clinical applications similar to those of mineral trioxide aggregate (MTA). It has been shown that CEM has higher antibacterial activity than MTA. On the other hand, use of chlorhexidine (CHX) to promote the antibacterial activity of different dental materials is increasing. The aim of the present study was to evaluate the effect of adding CHX to CEM on its antibacterial activity. The antibacterial activities of the materials under study [(CEM cement + CEM solution + 2%CHX) and (CEM cement + CEM solution)] against Pseudomonas aeroginosa, Enterococcus faecalis, Staphylococcus aureus and Escherichia coli were evaluated using agar diffusion technique, followed by determination of the diameter of microbial zone of inhibition around the materials by three independent observers after 72 h. Data were analyzed by Mann-Whitney U test. Statistical significance was defined at P<0.05. The mean diameters of zones of inhibition in the CEM + CEM liquid and CEM + CEM liquid + CHX groups against P. aeroginosa, E. faecalis, S. aureus and E. coli were (13.2 and 9), (21.10 and 6), (20.2 and 9) and (17 and 9.75) ml, respectively, with larger diameters in the CEM + CEM solution + CHX group as compared to CEM + CEM solution group with all the microorganisms (P<0.05). Incorporation of CHX with CEM resulted in an increase in antimicrobial activity of CEM.

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Chlorhexidine: An Adjunct to Periodontal Therapy

Abstract: Chlorhexidine is an effective antimicrobial agent. Its application can enhance periodontal therapy. The pharmacology of chlorhexidine and suggestions for its use are outlined. In addition, its potential for inducing cancer and bacterial resistance are discussed.

Cited by 167 publications

References 64 publications

Antibacterial capacity of cavity disinfectants against <i>Streptococcus mutans</i> and their effects on shear bond strength of a self-etch adhesive

Antibacterial capacity of cavity disinfectants against <i>Streptococcus mutans</i> and their effects on shear bond strength of a self-etch adhesive

In Vitro Comparative Evaluation of Effect of Different Irrigating Solutions on Mercury Released From Dental Amalgam

Effect of adding chlorhexidine to calcium enriched mixture (CEM) on its antimicrobial activity

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