1981
DOI: 10.1002/anie.198104021
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Chloranil as a Catalyst for the Electrochemical Oxidation of NADH to NAD+

Abstract: The IR-spectrum of (I) indicates that terminal hydrido hydrogen atoms are absent. In the 'H-NMR spectrum (80 MHz, [De]toluene) two sharp singlets, among other signals, appear at 6= -10.36 and -13.80 (2H each), which can be assigned to two groups of k2-hydrido bridges, which on the basis of the C,-symmetry of the cluster are chemically nonequivalent. Figure 2 shows the resulting structural scheme of (1). When the temperature is increased, the hydrido signals broaden, collapse together at CQ. 45 "C and eventual… Show more

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Cited by 35 publications
(9 citation statements)
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“…However, what is clear is that the k obs[NADH] ¼ 0 values are much higher when these mediators are bound to ZP compared with when adsorbed or bound to conventional electrode materials. A similar observation was made by Huck and Schmidt [33] when comparing the electrocatalytic activities of chloranil and benzoquinone adsorbed on graphite. This is expected as the positive shift in E 0 increases the thermodynamic driving force.…”
Section: Electrocatalytic Activity For Nadh Electro-oxidationsupporting
confidence: 81%
“…However, what is clear is that the k obs[NADH] ¼ 0 values are much higher when these mediators are bound to ZP compared with when adsorbed or bound to conventional electrode materials. A similar observation was made by Huck and Schmidt [33] when comparing the electrocatalytic activities of chloranil and benzoquinone adsorbed on graphite. This is expected as the positive shift in E 0 increases the thermodynamic driving force.…”
Section: Electrocatalytic Activity For Nadh Electro-oxidationsupporting
confidence: 81%
“…Thus, electrochemical activation of NAD(P) + -dependent enzymes requires the participation of an electrocatalyst capable of regenerating the NAD(P)H/NAD(P) + couple close to the thermodynamic redox potential (Figure 2.14). Different redox relays, such as o-quinones [45], p-quinones [46], phenazine, phenoxazine and phenothiazine derivatives [47], ferrocenes [48] and Os complexes [49], were applied as electrocatalysts for the regeneration of NAD(P) + cofactors. For the practical application of NAD(P) + -dependent enzymes as bioactive sensing matrices, integration of the electrocatalyst, the cofactor and the enzyme, as a united assembly that allows the electrochemical activation of the biocatalyst, is essential.…”
Section: Integrated Nad(p) + -Dependent Enzyme-electrodesmentioning
confidence: 99%
“…Using, for this aim, two-electron mediators one can expect only a minor amount of radicals produced [4]. Indeed, quinones [4 ±7] and phenoxazine derivatives containing quinoidic structures [8±10] have been used successfully as two-electron catalysts of NADH oxidation.…”
Section: Introductionmentioning
confidence: 99%