Chloramphenicol influence on antioxidant enzymes with preliminary approach on microsomal CYP1A immunopositive-protein in Chamelea gallina

Monari, Marta; Foschi, Jurgen; Cortesi, P.; Rosmini, Roberto; Cattani, Otello; Serrazanetti, Gian Paolo

doi:10.1016/j.chemosphere.2008.06.033

Cited by 6 publications

(6 citation statements)

References 71 publications

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“…However, the results of impaired levels of biochemical markers can be different depending on drug concentration, time, or animal species (Farombi 2001;Caipang et al 2009;Kladna et al 2012;Liu et al 2012Liu et al , 2014Elia et al 2014;Ren et al 2014). While the effects of chloramphenicol (Farombi 2001;Monari et al 2008) and other pharmaceuticals (Erdoğan et al 2004;Liu et al 2014) on fish and mammals are widely documented, little information is available for FF (Caipang et al 2009;Liu et al 2012;Ren et al 2014Ren et al , 2016.…”

Section: Discussionmentioning

confidence: 99%

“…Once inside cells, the drug undergoes biotransformation reactions producing higher concentrations of reactive oxygen species (ROS). Therefore, an important mechanism that determines the toxicity of FF (Ren et al 2014) and other antibiotics (Monari et al 2008;Kładna et al 2012) appears to be related to a change in antioxidant defenses due to ROS accumulation. Furthermore, antibiotic metabolites may exert more marked effects than those of parental molecules (Teo et al 1986;Lundén et al 2002).…”

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confidence: 99%

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Assessment of Detoxifying Markers for Florfenicol in Rainbow Trout Liver

et al. 2016

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Florfenicol (FF) is employed in fish farms to contest or prevent bacterial infections. However, this pharmaceutical may produce reactive oxygen species that may cause biochemical changes in antibiotic-treated fish. The aim of this study was to evaluate the effect of FF on Rainbow Trout Oncorhynchus mykiss treated for 10 d with 7.5 and 15 mg/kg FF followed by a withdrawal period of 5 d. Superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione S-transferase, glyoxalase I and glyoxalase II, total glutathione, lactic dehydrogenase, and alkaline phosphatase were investigated in the livers of treated and untreated fish. A general impairment of antioxidant enzymes and metabolic indicators was measured in FF-treated Rainbow Trout. Onset of oxidative damage may have occurred during the antibiotic treatment as a consequence of the effect of FF toxicity at mainly the highest dose. Nevertheless, the rise in levels of total glutathione and glutathione S-transferase even after the withdrawal period may shield the antibiotic-mediated oxidative processes. Received December 22, 2015; accepted May 26, 2016.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Assessment of Detoxifying Markers for Florfenicol in Rainbow Trout Liver

et al. 2016

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“…This result was similar to our study, in which medium and high level of CAP exposure significantly promoted Chlorophyll-a synthesis of Chlorella pyrenoidosa from 72 h to 20 d. But why this happened was still not clear and further study was needed to explain the phenomenon. Monari et al (2008) reported CAP influence on antioxidant enzymes in Chamelea gallina and found that SOD and CAT activities increased during the entire antibiotic exposure. SOD and CAT were important antioxidant defences against photogenerated free radicals, and usually used as a biomarker indicating ROS production (Ballesteros et al, 2009) (Elisabetta and Gioacchino, 2004;Ken et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Acute and Chronic Toxic Effects of Chloramphenicol on Scenedesmus Obliquus and Chlorella Pyrenoidosa

Zhang

Sun²,

An³

et al. 2013

Water Environment Research

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The acute and chronic toxicological effects of Chloramphenicol (CAP) on Scenedesmus obliquus and Chlorella pyrenoidosa are not well understood. The indoor experiments were carried to observe and analyze the CAP induced changes. Results of the observations have showed that CAP exposure could significantly inhibit the growth of Scenedesmus obliquus in almost all the treated groups, while Chlorella pyrenoidosa exhibited less sensitivity. Chlorophyll-a syntheses of Scenedesmus obliquus were all inhibited by CAP exposure, while Chlorella pyrenoidosa displayed obvious stimulation effect. Catalase (CAT) and Superoxide dismutase (SOD) activities of both algae were promoted in all the treatments. The experimental results indicated that the growth and Chlorophyll-a syntheses of Scenedesmus obliquus were more sensitive in response to CAP exposure than that of Chlorella pyrenoidosa. While for CAT and SOD activities, Chlorella pyrenoidosa showed more susceptible. This research provides a basic understanding of CAP toxicity to aquatic organisms.

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“…Treatments were: 1) basic DECOTAB, no invertebrates; 2) DECOTAB containing an antibiotic and fungicide, no invertebrates; 3) basic DECOTAB and C. riparius; and 4) basic DECOTAB and A. aquaticus. We did not include a treatment with DECOTAB containing both antibiotics and invertebrates because of the toxicity of both antibiotics to invertebrates (Baliga et al 1970, Monari et al 2008. We replicated each treatment 10 times.…”

Section: Experiments 1: Microbial Vs Invertebratemediated Decompositionmentioning

confidence: 99%

Invertebrate footprints on detritus processing, bacterial community structure, and spatiotemporal redox profiles

et al. 2012

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Chloramphenicol influence on antioxidant enzymes with preliminary approach on microsomal CYP1A immunopositive-protein in Chamelea gallina

Cited by 6 publications

References 71 publications

Assessment of Detoxifying Markers for Florfenicol in Rainbow Trout Liver

Assessment of Detoxifying Markers for Florfenicol in Rainbow Trout Liver

Acute and Chronic Toxic Effects of Chloramphenicol on Scenedesmus Obliquus and Chlorella Pyrenoidosa

Invertebrate footprints on detritus processing, bacterial community structure, and spatiotemporal redox profiles

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