Chloramphenicol-incorporated poly lactide-co-glycolide (PLGA) nanoparticles: Formulation, characterization, technetium-99m labeling and biodistribution studies

Investigation on design of stable etoposide-loaded PEG-PCL micelles: effect of molecular weight of PEG-PCL diblock copolymer on thein vitroandin vivoperformance of micelles

“…Furthermore, a higher liver uptake of micellar formulations compared to plain ETO, suggests RES uptake of the micelles. Nevertheless, the liver uptake of micellar formulations was two-to three-fold lower than the liver uptake of PLGA and PCL nanoparticles reported (Halder et al, 2008;Snehalatha et al, 2008). This was due to lower particle size of micellar formulations.…”

Cytotoxic Effect of Paclitaxel Incorporated in Nanoparticles Based on Lactic and Glycolic Acid Copolymer

“…In addition, polysorbate-80 adsorbed apolipoprotein E from the liquid phase. This was assumed to be one of the mechanisms providing the transport of nanoparticles of different nature, including LGAC nanoparticles, through the blood-brain barrier [2,[8][9][10]15]. Since P-glycoprotein was expressed by Jurkat-WT human T-lymphoblastic leukemia cells, it was interesting to compare cytotoxic activities of paclitaxel-containing nanoparticles not only with free paclitaxel, but also with compositions containing polysorbate-80.…”

Polylactide-Co-Glycolide Nanoparticles of Antitubercular Drugs: Formulation, Characterization and Biodistribution Studies

“…Radiolabeling of NPs and free drug suspension (FDS) with 99m Tc was performed by the procedure described elsewhere [30], with modification. For the preparation of aqueous solution of 99m TcO 4 and stannous chloride, nitrogenpurged water was used.…”