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Resveratrol is a substance of plant origin with antioxidant, anti-inflammatory, and chemoprotective properties used as a biologically active supplement in the prophylaxis of myocardial infarction, types 1 and 2 diabetes, and tumors. The aim of the present work was to develop and perform pharmacokinetic studies of a nanosomal form of resveratrol. The techniques described here yield particles of submicron size, with resveratrol yields of 70 -100% and resveratrol contents in lyophilized formulations reaching 15 -20%. After oral administration of unmodified resveratrol to mice, only 19% of the dose was taken up into the blood, while use of nanosomal resveratrol formulations based on Eudragit RL and lecithin/chitosan increased bioavailability to 39% and 61% respectively. Increases in the peak plasma resveratrol concentration by factors of 4 -5 were also seen in mice given nanoparticles. Thus, conversion of resveratrol to the nanosomal form leads to solubilization and resultant increases in absorption into the bloodstream.

A nanosomal formulation of moxifloxacin has been prepared by anionic polymerization of poly(butyl-2-cyanoacrylate) in the presence of the drug. The poly(butyl-2-cyanoacrylate) nanoparticles absorb effectively moxifloxacin with a high total content and have a considerable capacity (> 45%). The influence of reaction parameters such as pH and drug-to-polymer ratio on the nanoparticle characteristics has been studied. The efficacy of the novel formulation has been evaluated in mice infected with M. tuberculosis. It is shown that the efficacy of the proposed nanosomal formulation for i.v. administration evaluated by a decrease in the lung mycobacteria count is more than twice that of a reference preparation.

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The baseline impulse activity of neurons of the central nuclei of the cerebellum was investigated in awake cats under chronic experimental conditions through the use of various methods of statistical analysis. Differences were identified, along with the predominance of irregular impulse streams in the neurons of all the nuclei, in the relationship of individual varieties of the baseline activity of the neurons, both with respect to the pattern of the activity and with respect to the dynamics of the repetition of the interimpulse intervals, as well as with respect to other statistical characteristics of the distribution of the interimpulse intervals in each nucleus. It is hypothesized that the variations in the baseline impulse activity of neurons of individual nuclei are determined by their cytoarchitectonic features and by the varied distinctness of the correlating tonic afferent and cerebellar cortical influences.