Abstract:Two hundred and fifty-five neonates, infants and children, from 45 hospitals, who were receiving chloramphenicol therapy for serious infections were the subject of this study. Samples of serum and cerebrospinal fluid (CSF) were assayed for chloramphenicol and the patients' treatment regimens analysed. Less than 50% of neonates and 25% of infants received the "recommended" dose of chloramphenicol. In older children the recommended dose was used. Only 34% babies under 1 year of age and 50% older children had ser… Show more
“…Gray baby syndrome is a known adverse effect of chloramphenicol in neonatal infants [9,10]. Chloramphenicol is metabolized by uridine 5 0 -diphospho-glucuronosyltransferases in the liver and converted to the glucuronate conjugate.…”
“…Gray baby syndrome is a known adverse effect of chloramphenicol in neonatal infants [9,10]. Chloramphenicol is metabolized by uridine 5 0 -diphospho-glucuronosyltransferases in the liver and converted to the glucuronate conjugate.…”
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