Chloracne

Crow, K. D.

doi:10.1111/j.1365-2133.1970.tb15749.x

Cited by 13 publications

(20 citation statements)

References 1 publication

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“…When such statements are made, findings, such as porphyria cutanea tarda (66,67) and other systemic health effects (1) are largely ignored. However, it is not clear whether TCDD causes porphyria cutanea tarda in humans.…”

Section: Epidemiology Studiesmentioning

confidence: 99%

Laboratory and Human Studies on Polychlorinated Biphenyls (PCBs) and Related Compounds

Kimbrough¹

1985

Environmental Health Perspectives

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Similar qualitative toxic effects have been observed in animals for a class of halogenated aromatic compounds, which include the halogenated biphenyls, naphthalenes, dibenzodioxins, and dibenzofurans. All of these compounds are lipid soluble and persist in the environment and in mammals. The polybrominated biphenyls (PBBs) are the most persistent. They are predominantly stored in fatty tissue; they pass the placenta and are excreted in milk. Some isomers of the halogenated biphenyls are more toxic than others. With some exceptions, the more toxic isomers are retained longer in tissues and are also the carcinogenic components of the mixture. Most of these chemicals seem to be promoters of carcinogenesis in animals rather than initiators. An array of toxic effects in laboratory animals has been ascribed to these compounds and numerous reviews summarizing this information are available. Less information is available on the human health effects of environmental and occupational exposure. Results of recent studies in animals to further elucidate the effects of these chemicals are presented, and results from some human studies conducted in the United States are reviewed.

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Section: Epidemiology Studiesmentioning

confidence: 99%

Laboratory and Human Studies on Polychlorinated Biphenyls (PCBs) and Related Compounds

Kimbrough¹

1985

Environmental Health Perspectives

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“…It is characterized by very high environmental stability and the ability to be concentrated in animal and human body tissues (109). TCDD toxic action invokes a variety of adverse effects, but one of the most sensitive and widespread responses to TCDD observed in humans is chloracne (110,111), a skin lesion characterized by altered proliferative and differentiation patterns in the epidermis and its appendages, including acanthosis, hyperkeratosis, squam-ous metaplasia of the epithelial lining of the sebaceous glands, and hair follicle atrophy (112). In laboratory animals, TCDD induces the coordinated expression of a battery of enzymes involved in the regulation of cellular homeostasis.…”

Section: Hr-dependent Susceptibility To Dioxin Skin Toxicitymentioning

confidence: 99%

Molecular and functional aspects of the hairless (hr) gene in laboratory rodents and humans

Panteleyev¹,

Paus

Ahmad³

et al. 1998

Experimental Dermatology

118

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“…Photography of the entire body is desirable. At the present time, chloracne is rarely observed after dioxin or PCB exposure, and its diagnosis varies from physician to physician, with widely differing criteria being used (11)(12)(13) Next, a careful examination of the eyes is indicated, remembering the Yusho patients and their conjunctivitis and discharge (14,15). Staining of gingiva may be found after exposure to PCBs and furans, again as seen in Yusho.…”

Section: Medical Examinationmentioning

confidence: 99%

Medical surveillance of exposed persons after exposure to PCBs, chlorinated dibenzodioxins and dibenzofurans after PCB transformer or capacitor incidents.

Schecter¹

1985

Environ Health Perspect

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The panel discussion from the perspective of occupational medicine regarding appropriate medical surveillance after a PCB transformer or capacitor incident is reviewed. A thorough occupational medicine history and physical examination is stressed for any worker or other patient who may have been exposed. Appropriate laboratory tests, including complete blood count with differential, serum chemistries, serial blood PCB determiniations, fat biopsy to estimate furan and dioxin levels, if indicated, pulmonary function tests, chest X-rays, urinalysis including porphyrin measurement, nerve conduction velocity testing and other tests are discussed. No consensus was reached on recommended length of medical followup.Because the field is rapidly changing, yearly updates of medical protocols are warranted. In addition, the need for surveillance to be conducted by specialists with training and experience in the fields of occupational medicine and nursing was emphasized. It was stressed that measuring the chemicals and their levels in soot and air and then comparing these with the patient's blood or fat levels, in the case of PCBs, furans and dioxins, is vital. It was noted that at present no modality of treatment is known to be clinically efficacious in removing PCBs, furans and dioxins from tissues or blood.

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Chloracne

Cited by 13 publications

References 1 publication

Laboratory and Human Studies on Polychlorinated Biphenyls (PCBs) and Related Compounds

Laboratory and Human Studies on Polychlorinated Biphenyls (PCBs) and Related Compounds

Molecular and functional aspects of the hairless (hr) gene in laboratory rodents and humans

Medical surveillance of exposed persons after exposure to PCBs, chlorinated dibenzodioxins and dibenzofurans after PCB transformer or capacitor incidents.

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