Chlamydia trachomatis in chronic abacterial prostatitis: Demonstration by colorimetric in situ hybridization

Abdelatif, Osama; Chandler, Francis W.; McGuire, Byron S.

doi:10.1016/0046-8177(91)90059-x

Cited by 57 publications

(21 citation statements)

References 11 publications

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“…These include Chlamydia trachomatis, human papillomavirus (HPV), and human herpesvirus type 8 (HHV-8) infections. C. trachomatis is a putative, candidate infection because it is intracellular and is often asymptomatic in men, which may allow it to persist in the male genitourinary tract and possibly ascend to the prostate, where it has been observed to infect prostate epithelial cells and elicit an intraprostatic inflammatory immune response (4)(5)(6). HPV and HHV-8 infections are putative candidates because they have both been associated with other cancers (cervical, vulval, anal, and penile carcinomas and Kaposi's sarcoma; refs.…”

Section: Introductionmentioning

confidence: 99%

Plasma Antibodies against Chlamydia trachomatis, Human Papillomavirus, and Human Herpesvirus Type 8 in Relation to Prostate Cancer: A Prospective Study

Sutcliffe

Giovannucci

Gaydos

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Traditionally, case-control studies of sexually transmitted infections and prostate cancer have focused on gonorrhea and syphilis, with overall positive associations. More recently, researchers have begun to expand their focus to include additional sexually transmitted infections, such as Chlamydia trachomatis, human papillomavirus (HPV), and human herpesvirus type 8 (HHV-8) infections. Continuing this investigation, we examined each of these infections in relation to incident prostate cancer in a nested case-control study within the Health Professionals Follow-up Study. Prostate cancer cases were men diagnosed with prostate cancer between the date of blood draw (1993)(1994)(1995) and 2000 (n = 691). Controls were men free of cancer and alive at the time of case diagnosis who had had at least one prostatespecific antigen test between the date of blood draw and case diagnosis. One control was individually matched to each case by age; year, time of day, and season of blood draw; and prostate-specific antigen screening history before blood draw (n = 691). C. trachomatis and HPV-16, HPV-18, and HPV-33 antibody serostatus were assessed by enzyme-based immunoassays and HHV-8 antibody serostatus was assessed by an immunofluorescence assay. No associations were observed between C. trachomatis [odds ratio (OR), 1.13; 95% confidence interval (95% CI), 0.65-1.96], HPV-16 (OR, 0.83; 95% CI, 0.57-1.23), HPV-18 (OR, 1.04; 95% CI, 0.66-1.64), and HPV-33 (OR, 1.14; 95% CI, 0.76-1.72) antibody seropositivity and prostate cancer. A significant inverse association was observed between HHV-8 antibody seropositivity and prostate cancer (OR, 0.70; 95% CI, 0.52-0.95). As this study is the first, to our knowledge, to observe such an inverse association, similar additional studies are warranted. (Cancer Epidemiol Biomarkers Prev 2007;16(8):1573 -80)

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Section: Introductionmentioning

confidence: 99%

Plasma Antibodies against Chlamydia trachomatis, Human Papillomavirus, and Human Herpesvirus Type 8 in Relation to Prostate Cancer: A Prospective Study

Sutcliffe

Giovannucci

Gaydos

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…However, the sensitivity of C. trachomatis screen ing by culture of mammalian cell monolayers, enzymelinked immunosorbent assay (ELISA), or direct immuno fluorescence with specific monoclonal antibody is limited [7,8]. Recently, in situ hybridization has been reported to be useful for the detection of C. trachomatis in clinical specimens [9][10][11], In this study, we assayed for C. tracho matis in the semen of asymptomatic infertile men by in situ hybridization and attempted to correlate the presence of C. trachomatis with evidence for inflammation by the determination of the polymorphonuclear granulocyte (PMN)-elastase concentration.…”

Section: Introductionmentioning

confidence: 99%

<i>Chlamydia trachomatis</i> Infection in the Semen of Asymptomatic Infertile Men: Detection of the Antigen by in situ Hybridization

Yoshida

Kobayashi²,

Negishi³

1994

Urol Int

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The prevalence of Chlamydia trachomatis and other microbes was studied in 94 semen samples from asymptomatic infertile males. Simultaneously, we sought evidence for inflammation of the genital tract by determining the polymorphonuclear granulocyte (PMN)-elastase concentration in the seminal plasma. The C. trachomatis genome was detected in 8 cases using in situ hybridization. The antigen, however, was undetectable by enzyme-linked assay (Chlamydiazyme) in the same samples. Ureaplasma urealyticum was isolated from 16 cases. The PMN-elastase concentration in the semen positive for the C. trachomatis genome was significantly higher than in C trachomatis-negative and U. urealyticum-positive cases, but no significant difference was observed between C. trachomatis-mgative and U. urealyticum-positive cases. C. trachomatis in situ hybridization-positive cases correlated well with C trachomatis-specific IgA antibody positivity and a PMN-elastase concentration over 250 ng/ml. These findings suggest that in situ hybridization is a reliable method for the detection of C. trachomatis infection and that the presence of C. trachomatis, but not U. urealyticum, in the male genital tract correlated well with evidence of inflammation.

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“…This does not demonstrate causation. It is interesting that Abdelatif et al [18] found evidence of Chlamydia within the prostate; however, it is unknown whether the patients in this study were symptomatic. Transperineal biopsy studies are an improvement because they do not suffer from the risks of urethral contamination; as with any biopsy study, however, the possibility of sampling error must be acknowledged.…”

Section: Chlamydia Trachomatismentioning

confidence: 80%

“…Abdelatif et al [18] evaluated 23 transurethrally resected prostate specimens with histologic evidence of CPPS. They used colorimetric in situ hybridization to look for evidence of Chlamydia.…”

Section: Chlamydia Trachomatismentioning

confidence: 99%

Microbiology of the Prostate

Lee

2000

Curr Urol Rep

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Prostatitis is a common genitourinary disease in men. The National Institutes of Health has defined four types of prostatitis. The bacteriology of acute and chronic bacterial prostatitis is well understood. Causative organisms can be isolated by four-glass urine cultures. Chronic pelvic pain syndrome (CPPS; chronic abacterial prostatitis) is an enigma; whether there is a microbiologic cause for this condition is unknown. Researchers have postulated that CPPS may be an infectious disease of the prostate. This article reviews current literature regarding the microbiology of the prostate in CPPS.

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Chlamydia trachomatis in chronic abacterial prostatitis: Demonstration by colorimetric in situ hybridization

Cited by 57 publications

References 11 publications

Plasma Antibodies against Chlamydia trachomatis, Human Papillomavirus, and Human Herpesvirus Type 8 in Relation to Prostate Cancer: A Prospective Study

Plasma Antibodies against Chlamydia trachomatis, Human Papillomavirus, and Human Herpesvirus Type 8 in Relation to Prostate Cancer: A Prospective Study

<i>Chlamydia trachomatis</i> Infection in the Semen of Asymptomatic Infertile Men: Detection of the Antigen by in situ Hybridization

Microbiology of the Prostate

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