Microbiology of the Prostate

Lee, J. C.

doi:10.1007/s11934-000-0052-y

Cited by 4 publications

(3 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mechanistic understandings of a number of diseases that are believed to have microbial axes have escaped conventional biological analyses [1]–[3]. The application of integrative systems biology approaches exploiting multiple data sources holds much promise in developing a fuller understanding of these diseases [4], [5].…”

Section: Introductionmentioning

confidence: 99%

A Multi-Omic Systems-Based Approach Reveals Metabolic Markers of Bacterial Vaginosis and Insight into the Disease

et al. 2013

View full text Add to dashboard Cite

BackgroundBacterial vaginosis (BV) is the most common vaginal disorder of reproductive-age women. Yet the cause of BV has not been established. To uncover key determinants of BV, we employed a multi-omic, systems-biology approach, including both deep 16S rRNA gene-based sequencing and metabolomics of lavage samples from 36 women. These women varied demographically, behaviorally, and in terms of health status and symptoms.Principal Findings16S rRNA gene-based community composition profiles reflected Nugent scores, but not Amsel criteria. In contrast, metabolomic profiles were markedly more concordant with Amsel criteria. Metabolomic profiles revealed two distinct symptomatic BV types (SBVI and SBVII) with similar characteristics that indicated disruption of epithelial integrity, but each type was correlated to the presence of different microbial taxa and metabolites, as well as to different host behaviors. The characteristic odor associated with BV was linked to increases in putrescine and cadaverine, which were both linked to Dialister spp. Additional correlations were seen with the presence of discharge, 2-methyl-2-hydroxybutanoic acid, and Mobiluncus spp., and with pain, diethylene glycol and Gardnerella spp.ConclusionsThe results not only provide useful diagnostic biomarkers, but also may ultimately provide much needed insight into the determinants of BV.

show abstract

Section: Introductionmentioning

confidence: 99%

A Multi-Omic Systems-Based Approach Reveals Metabolic Markers of Bacterial Vaginosis and Insight into the Disease

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Approximately a quarter of the ejaculate is composed of secretions produced by the prostatic epithelium [ 31 ]. While previous studies suggested the existence of a prostate microbiota [ 32 , 33 ], only studies relying on NGS could reveal an unbiased composition of the bacterial taxa ( Table 1 ).…”

Section: Microbiota Of the Mgtmentioning

confidence: 98%

Human Male Genital Tract Microbiota

Zuber

Peric²,

Pluchino

et al. 2023

IJMS

View full text Add to dashboard Cite

The human body is vastly colonised by microorganisms, whose impact on health is increasingly recognised. The human genital tract hosts a diverse microbiota, and an increasing number of studies on the male genital tract microbiota suggest that bacteria have a role in male infertility and pathological conditions, such as prostate cancer. Nevertheless, this research field remains understudied. The study of bacterial colonisation of the male genital tract is highly impacted by the invasive nature of sampling and the low abundance of the microbiota. Therefore, most studies relied on the analysis of semen microbiota to describe the colonisation of the male genital tract (MGT), which was thought to be sterile. The aim of this narrative review is to present the results of studies that used next-generation sequencing (NGS) to profile the bacterial colonisation patterns of different male genital tract anatomical compartments and critically highlight their findings and their weaknesses. Moreover, we identified potential research axes that may be crucial for our understanding of the male genital tract microbiota and its impact on male infertility and pathophysiology.

show abstract

“…It was found that gram positive Staphylococci species involved in the pathogenesis of chronic pelvic pain syndrome[18]. They were identified in the focal colonies adherent to the prostatic duct walls[19]. Bergman demonstrated that gram positive Staphylococci species were found in significant numbers in 43% of patients with symptoms of prostatitis[20].…”

mentioning

confidence: 99%

Tracing of Antibiotic-Resistant Bacteria Isolated from Semen of Iraqi Males with Primary Infertility

Al-Jebouri¹,

Mdish²

2019

OJU

View full text Add to dashboard Cite

Objectives: The main objective of this study was to investigate the bacterial infections of seminal fluid in males with primary infertility. The patients were referred to and/or visiting the Urology Department in Salah Al-Deen Teaching Hospital. Methods: The present study was carried out from May 2017 to June 2018 and the number of the patients group was 60. The patients aged between 20 to 50 years. Semen was collected from infertile men of a couple that female failed to become pregnant after one year of regular and unprotected intercourse of marriage and submitted for seminal fluid analysis for the bacteriological analyses. The control group consisted of 50 fertile male who were selected randomly from Tikrit City during the period of this study. Semen culture was done for all the patients and the control group. Results: There were 30 patients who suffered from bacteriospermia and 16 of them (53.3%) were infected with gram positive organisms, while only 14 (46.7%) patients were infected with gram negative organisms. The most common organism was Staphylococcus aureus which was isolated from bacteriospermia. Escherichia coli, Enterococcus faecalis, Klebsiella pneumoniae, S. saprophyticus, Proteus mirabilis and Niesseria gonorrhoae were also isolated and the frequencies of isolation were 23.3% (7), 13.3% (4), 10.0% (3), 10.0% (3), 6.6% (2), and 6.6% (2) respectively. The present study showed many antibiotics were not active against gram positive bacteria isolated e.g. the resistance frequenciy to rifampcin, vancomycin and clindamycin was 48%, 44% and 40% respectively. Conclusions: The gram positive organisms were more prevalent than gram negative organisms in patients with bacteriospermia and the isolationfrequencies of two groups were 16 (53.3%) and 14 (46.7%) respectively. The most effective antimicrobial agents were amikacin, ciprofloxacin and levofloxacin and the least effective one was ceftazidime, whereas moxifloxacin,

show abstract

Microbiology of the Prostate

Cited by 4 publications

References 37 publications

A Multi-Omic Systems-Based Approach Reveals Metabolic Markers of Bacterial Vaginosis and Insight into the Disease

A Multi-Omic Systems-Based Approach Reveals Metabolic Markers of Bacterial Vaginosis and Insight into the Disease

Human Male Genital Tract Microbiota

Tracing of Antibiotic-Resistant Bacteria Isolated from Semen of Iraqi Males with Primary Infertility

Contact Info

Product

Resources

About