Chlamydia trachomatis and male infertility in Tunisia

Gdoura, Radhouane; Keskes, Leila; Bouzid, Fériel; Eb, F.; Hammami, A.; Orfila, J

doi:10.1080/713604209

Cited by 22 publications

(35 citation statements)

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“…Rybar et al [9] showed a reduction in sperm numbers. Separate studies by Cengiz et al [12], Gallegos et al [13], Gdoura et al [14], and Kokab et al [16] all confirm that the presence of Chlamydia is indeed associated with a reduction of the percentage of progressively motile sperm with Cengiz et al [12] also demonstrating abnormal morphology and reduced viability. Gallegos et al [13], reported sperm DNA fragmentation that improved when the Chlamydia infection was treated, this is contradictory to the findings of Gdoura et al [14], who found no evidence of DNA fragmentation.…”

Section: Male Accessory Gland Infectionsmentioning

confidence: 98%

Sexually Transmitted Infections and Sexual Function in Relation to Male Fertility

2013

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Infertility affects about 8% to 12% of couples, with male infertility being responsible for about 30% of cases. Sexually transmitted infections (STIs) are known to cause complications of pregnancy and are associated with tubal infertility in females, but the association with male fertility is still controversial. The prevalence of curable STIs has risen to an estimated 448 million a year with the number of people living with human immunodeficiency virus (HIV) at 34 million. This review looks at the evidence available to date, regarding the effect of STIs and male accessory gland infections on markers of male fertility and the evidence that STIs negatively affect sexual functioning, thus adversely affecting the ability to conceive. The review will also cover new developments in the use of medications and fertility treatments as an aid to conception in couples serodiscordant for HIV.

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Section: Male Accessory Gland Infectionsmentioning

confidence: 98%

Sexually Transmitted Infections and Sexual Function in Relation to Male Fertility

2013

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“…According to a World Health Organization (WHO) [3] report, C. trachomatis is responsible for the most common sexually transmitted bacterial infection worldwide, affecting more than 90 million people and has been known for some time to have a significant effect on human reproduction [4]. The role of C. trachomatis infections in male infertility is controversial [5]–[6]. A number of studies have specifically looked at the relationship between Chlamydial infection and semen quality.…”

Section: Introductionmentioning

confidence: 99%

Molecular Detection of Chlamydia trachomatis and Other Sexually Transmitted Bacteria in Semen of Male Partners of Infertile Couples in Tunisia: The Effect on Semen Parameters and Spermatozoa Apoptosis Markers

et al. 2014

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This study was undertaken to determine the prevalence of Chlamydia trachomatis, Mycoplasmas, and Ureaplasmas in semen samples of the male partners of infertile couples and to investigate whether Chlamydia trachomatis could initiate apoptosis in human spermatozoa. A total of 85 males partners of infertile couples undergoing routine semen analysis according to World Health Organization guidelines were included. Specimens were examined for the presence of Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma hominis, Mycoplasma genitalium, Ureaplasma urealyticum and Ureaplasma parvum by Real time PCR (qPCR). Semen specimens were analysed for the appearance of apoptotic markers (sperm DNA fragmentation, activated caspase 3 levels, mitochondrial membrane potential (ΔΨm)) using flow cytometry. C. trachomatis, N. gonorrhoeae, U. urealyticum, M genitalium were detected in semen samples of 13 (15.2%), 5 (5.8%), 5 (5.8%) and 3 (3.5%) male partners of infertile couples, respectively. M. hominis and U. parvum were detected in semen sample of only one patient (1.1%). The semen of infertile men positive for C. trachomatis showed lower mean of semen count and lower rapid progressive motility (category [a]) of spermatozoa compared to uninfected men with statistically significances (p = 0.02 and p = 0.04, respectively). Flow cytometry analyses demonstrated a significant increase of the mean rate of semen with low ΔΨm and caspase 3 activation of infertile men positive for C. trachomatis compared to uninfected men (p = 0.006 and p = 0.001, respectively). DNA fragmentation was also increased in sperm of infertile men positive for C. trachomatis compared to uninfected men but without statistical significances (p = 0.62). Chlamydial infection was associated to loss of ΔΨm and caspase 3activation. Thus, C. trachomatis infection could be incriminated in apoptosis induction of spermatozoa. These effects may explain the negative direct impact of C. trachomatis infection on sperm fertilizing ability.

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“…The prevalence in the current study is quite higher than 9.8% in Enugu, Nigeria (Ikeme et al, 2011). Varying prevalence of C. trachomatis among infertile male subjects has been documented from other parts of world, 4.5% in Amiens, France (HamdadDaoudi et al, 2004) and 35.9% in Tunisia (Gdoura, 2001). The high prevalence of C. trachomatis in this study shows that the pathogen poses to be a continuous threat to the fertility of men in our locality.…”

mentioning

confidence: 54%

The prevalence of Chlamydia trachomatis infection among infertile males and its association with abnormal semen characteristics in Delta State, Nigeria

Osazuwa¹,

Aiguobarueghian²,

Alekwe

et al. 2013

Tanzania J Hlth Res

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Chlamydia trachomatis is the most common cause of sexually transmitted diseases that is not of viral origin and there is accumulating evidence of a significant role played by this pathogen in causing male factor infertility. This study thus aimed to determine the prevalence of C. trachomatis among infertile males and to evaluate their association with fertility status and abnormal semen characteristics. This study included 215 infertile male subjects who visited a major fertility clinic in Warri, Delta state, Nigeria. Forty apparently healthy males without complaints of infertility were enrolled as controls. Blood samples were collected from patients aseptically using venous puncture and semen samples were obtained after masturbation. C. trachomatis IgG antibodies were assayed for in blood specimens using the Dot rapid Assay Kit flow through Ct cassette and positive samples were further screened with an enzyme immunoassay technique. Semen samples were analyzed following World Health Organization guidelines. Forty-two (19.5%) out of 215 infertile male subjects were found sero-positive for C. trachomatis. C. trachomatis was significantly associated with male infertility when compared to controls (P<0.001). Age groups 20-29 years (43.3%) and 30-39 years (22.1%) significantly had higher prevalence of C. trachomatis (P<0.001), as compared to age groups 40-49 (7.9%) and > 50 years (3.7%). Sero-positivity for C. trachomatis antibodies was significantly associated with oligozoospermia (22.5%) and azospermia (61.5%) than with teratozoospermia (7.3%) and asthenozoospermia (6.3%) (P<0.001). The prevalence of C. trachomatis among infertile males was high; there was an association between C. trachomatis infection and poor semen characteristics and infertility. There is need for routine screening for the pathogen in males with complaints of infertility so as to rule out this potentially correctable/reversible cause of infertility.____________________________________________________________________________________

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Chlamydia trachomatis and male infertility in Tunisia

Abstract: Our results show that C. trachomatis seems to be widespread among the male partners of infertile couples in Tunisia and show that this organism can affect sperm motility and, thus, can play an important role in the etiology of male infertility.

Cited by 22 publications

References 0 publications

Sexually Transmitted Infections and Sexual Function in Relation to Male Fertility

Sexually Transmitted Infections and Sexual Function in Relation to Male Fertility

Molecular Detection of Chlamydia trachomatis and Other Sexually Transmitted Bacteria in Semen of Male Partners of Infertile Couples in Tunisia: The Effect on Semen Parameters and Spermatozoa Apoptosis Markers

The prevalence of Chlamydia trachomatis infection among infertile males and its association with abnormal semen characteristics in Delta State, Nigeria

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