Sexually Transmitted Infections and Sexual Function in Relation to Male Fertility

Brookings, Claire; Goldmeier, David; Sadeghi‐Nejad, Hossein

doi:10.4111/kju.2013.54.3.149

Cited by 35 publications

(16 citation statements)

References 58 publications

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“…Other infectious causes of orchitis in both HIV-infected and non-HIV-infected men include bacteria, such as Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus spp., and Streptococcus spp., and viruses, such as mumps, varicella, coxsackievirus, and echovirus. [45] These infections may also contribute to infertility.…”

Section: Other Infectionsmentioning

confidence: 99%

HIV Infection and Infertility

Khawcharoenporn¹,

Sha²

2016

Genital Infections and Infertility

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Human immunodeficiency virus (HIV) infection has become a chronic and manageable disease since the availability of combination antiretroviral therapy (cART). Persons living with HIV are living longer with better quality of life. Given that worldwide many HIV-infected individuals are in the reproductive age, fertility and reproductive desire have emerged as clinically important issues among this population. Biological changes caused by HIV, including systemic illnesses, stress, and weight loss, may affect the function of reproductive organs and result in infertility. Newly diagnosed HIV infection may cause psychological trauma and decrease in sexual drive and sexual activity. Several HIV/acquired immune deficiency syndrome (AIDS)-related comorbidities have been reported to be associated with infertility. These include orchitis, acute epididymitis, and pelvic inflammatory disease caused by opportunistic pathogens and coinfections with sexually transmitted infections (STIs) acquired through a similar route of transmission as HIV. The common STIs caused by Neisseria gonorrhoeae, Chlamydia trachomatis, Ureaplasma urealyticum, Treponema pallidum, herpes simplex virus-2, and Trichomonas vaginalis can damage the reproductive system and cause infertility. Hypogonadism especially in men with AIDS is one of the important endocrine disorders that causes infertility. Although cART provides significant benefits in reducing morbidity and mortality among HIV-infected persons, some antiretroviral drugs, including nucleoside reverse transcriptase inhibitors, are toxic to cellular mitochondria and may affect the mitochondrial biogenesis of sperm and oocytes. HIV-infected individuals may have limited access to reproductive care given the severity of their disease, cost of care, stigmatization, and lack of specific HIV infection/infertility knowledge among their providers. In the post-cART era, reproductive care has become an important issue to be comanaged with HIV care. Reproductive care includes not only comprehensively managing HIV infection but also minimizing the risk of horizontal HIV transmission in serodiscordant couples, providing suitable options for unprotected timed intercourse, intrauterine insemination with partner or donor sperm, in vitro fertilization with intracytoplasmic sperm injection (IVF/ICSI), embryo donation, and adoption. This chapter reviews potential effects of HIV infection, related opportunistic infections, and physical and psychological comorbidities on fertility; the im

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Section: Other Infectionsmentioning

confidence: 99%

HIV Infection and Infertility

Khawcharoenporn¹,

Sha²

2016

Genital Infections and Infertility

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“…Gonorrhea is a sexually transmitted infection (STI) causing urethral or cervical discharge and ocular, pharyngeal, and anorectal infections [5]. Worldwide, an estimated 62 million new infections of gonorrhea occur annually [6], making it the second most common STI. The infectious agent, Neisseria gonorrhoeae remains asymptomatic in as high as 55% of men and 86% of women [7].…”

Section: Introductionmentioning

confidence: 99%

Activity of the Medicinal Plant Parkia Javanica Against Neisseria Gonorrhoeae Multi Drug Resistant and Other Clinical Isolates

Mullick

Majumdar

Reddy³

et al. 2019

Asian J Pharm Clin Res

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Objective: The objective of this study was to look into the in vitro activity of Parkia javanica against isolates of Neisseria gonorrhoeae. Methods: Methanolic extract of P. javanica bark (MEPJ) and organic fractionation were tested against one standard strain and 10 clinical isolates including one multidrug-resistant (MDR) isolate of N. gonorrhoeae through minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC) tests. Results: The MDR isolate, standard strain, as well as all the clinical isolates were inhibited by MEPJ as well as all the fractions except water fraction. Chloroform fraction showed the best activity with MIC and MBC values, both being 0.2 mg/ml. Ethyl acetate fraction also showed MIC value at 0.2 mg/ml; however, MBC value was at 0.3 mg/ml. MIC and MBC values of MEPJ were both 0.3 mg/ml. Conclusion: Chloroform fraction, ethyl acetate fraction, and MEPJ bark showed the lowest MIC values and can be considered as prospective candidates for the development of antigonococcal topical drugs.

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“…Therefore, it is very important to elucidate the underlying mechanisms to prevent and treat infertility. The etiologies of infertility are diverse and include endocrinological, anatomical, genetic, infectious, behavioral, environmental, or unexplained factors [ 5 , 25 ]. Among these, Chlamydia trachomatis , Neisseria gonorrhea , Ureaplasma urealyticum , Ureaplasma parvum , Mycoplasma hominis , and Mycoplasma genitalium are well-known bacterial infectious agents that cause both male and female infertility [ 33 ].…”

Section: Introductionmentioning

confidence: 99%

“…Among these, Chlamydia trachomatis , Neisseria gonorrhea , Ureaplasma urealyticum , Ureaplasma parvum , Mycoplasma hominis , and Mycoplasma genitalium are well-known bacterial infectious agents that cause both male and female infertility [ 33 ]. Furthermore, hepatitis B (HBV) and C (HCV) viruses, human immunodeficiency virus (HIV), human papillomavirus (HPV), herpes simplex virus (HSV), and cytomegalovirus (CMV) are considered risk factors for male infertility [ 5 , 13 ]. However, viral agents associated with human female infertility are still unknown.…”

Section: Introductionmentioning

confidence: 99%

Coxsackievirus B3 infection reduces female mouse fertility

et al. 2015

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Previously we demonstrated coxsackievirus B3 (CVB3) infection during early gestation as a cause of pregnancy loss. Here, we investigated the impacts of CVB3 infection on female mouse fertility. Coxsackievirus-adenovirus receptor (CAR) expression and CVB3 replication in the ovary were evaluated by immunohistochemistry or reverse transcription-polymerase chain reaction (RT-PCR). CAR was highly expressed in granulosa cells (GCs) and CVB3 replicated in the ovary. Histological analysis showed a significant increase in the number of atretic follicles in the ovaries of CVB3-infected mice (CVBM). Estrous cycle evaluation demonstrated that a higher number of CVBM were in proestrus compared to mock mice (CVBM vs. mock; 61.5%, 28.5%, respectively). Estradiol concentration in GC culture supernatant and serum were measured by an enzyme-linked immunosorbent assay. Baseline and stimulated levels of estradiol in GC were decreased in CVBM, consistent with significantly reduced serum levels in these animals. In addition, aromatase transcript levels in GCs from CVBM were also decreased by 40% relative to the mock. Bone mineral density evaluated by micro-computed tomography was significantly decreased in the CVBM. Moreover, the fertility rate was also significantly decreased for the CVBM compared to the mock (CVBM vs. mock; 20%, 94.7%, respectively). This study suggests that CVB3 infection could interfere with reproduction by disturbing ovarian function and cyclic changes of the uterus.

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Sexually Transmitted Infections and Sexual Function in Relation to Male Fertility

Cited by 35 publications

References 58 publications

HIV Infection and Infertility

HIV Infection and Infertility

Activity of the Medicinal Plant Parkia Javanica Against Neisseria Gonorrhoeae Multi Drug Resistant and Other Clinical Isolates

Coxsackievirus B3 infection reduces female mouse fertility

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