Chlamydia pneumoniae in central retinal artery occlusion

Abstract

ABSTRACT.Purpose: There is increasing evidence that the common respiratory human pathogen Chlamydia pneumoniae has a causative role in atherosclerosis. We investigated the association of this pathogen with acute central retinal artery occlusion (CRAO). Patients and Methods: Sera of 14 consecutive patients with CRAO and of 14 age-and sex-matched control subjects were examined. Antibodies against chlamydial lipopolysaccharide (LPS) and outer membrane proteins of C. pneumoniae were determined by an enzyme-linked immunosorbent assay (ELISA). Results: In the CRAO group, seven patients (50%) were found to be IgA positive, 12 (86%) were IgG positive and one (7%) was IgM positive for chlamydial LPS antibodies. In the control group 36%, 79% and 14% were IgA, IgG and IgM positive, respectively. The results showed no significant difference between the groups. In the CRAO group, IgA, IgG and IgM antibodies to C. pneumoniae were found in 43%, 79% and 0% of subjects, respectively. These findings did not differ significantly from those pertaining to matched controls. Conclusions: These data do not support an association between acute CRAO and current C. pneumoniae infection.

The Relationship Between Seropositivity Against Chlamydia pneumoniae and Stroke and its Subtypes in a Latvian Population

“…Furthermore, various studies employed different methods. Some trials that employed serologic methods have demonstrated a link between seropositivity to C. pneumoniae and an acute cerebrovascular accident (4-8), whereas others have not (9)(10)(11). Moreover, some studies have confi rmed the presence of C. pneumoniae in the atherosclerotic plaque by molecular genetic methods (13)(14)(15)(16)(17), but a considerable number of studies have not reported any association (18)(19)(20)(21).…”

“…The relationship between C. pneumoniae and stroke has not been confirmed by all trials; therefore, the data are controversial. Several serologic studies have established a link between seropositivity and acute cerebrovascular accident (4-8), while others have not demonstrated any association (9)(10)(11).…”

Elevated Serum Immunoglobulin G Titers Against Chlamydia pneumoniae in Primary Open-Angle Glaucoma Patients Without Systemic Disease

“…36 C. pneumoniae has been reported to be associated with ocular diseases such as optic neuritis, central retinal artery occlusion, acute anterior uveitis, and anterior optic neuropathy, which may be associated with vascular or inflammatory factors. [44][45][46][47][48][49] This mechanism may lead to vascular dysregulation and the reduction of ocular blood flow at the optic nerve head that may cause glaucomatous optic neuropathy without an IOP elevation.…”