Chlamydia Pneumoniae in Asymptomatic Carotid Atherosclerosis

Sessa, Rosa; Pietro, Marisa Di; Schiavoni, Giovanna; Galdiero, Marilena; Cipriani, Paola; Romano, Silvio; Zagaglia, Carlo; Santino, Iolanda; Faccilongo, S.; Piano, M. Del

doi:10.1177/205873920601900111

Cited by 20 publications

(19 citation statements)

References 33 publications

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“…Indeed, the detection of chlamydial DNA by polymerase chain reaction (PCR) has contributed significantly in demonstrating the association of C. pneumoniae with atherosclerotic cardiovascular disease (7,(24)(25)(26)(27). Therefore, we believe that direct detection of C. pneumoniae in tumor lung tissue is needed to support its involvement in the pathogenesis oflung cancer.…”

mentioning

confidence: 99%

No Evidence of Involvement ofChlamydia Pneumoniaein Lung Cancer by Means of Quantitative Real-Time Polymerase Chain Reaction

Sessa¹,

Santino²,

M³

et al. 2008

Int J Immunopathol Pharmacol

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Chlamydia pneumoniae, an obligate intracellular pathogen, is well-known as etiological agent of acute respiratory infections; the repeated or prolonged exposure to chlamydial antigens may promote the persistence of C. pneumoniae in the respiratory tract leading to chronic diseases, such as chronic obstructive pulmonary disease and asthma. The predilection of C. pneumoniae to cause respiratory tract infections combined with its persistent nature suggest that it might play a role in lung cancer. The aim of our study is to evaluate the involvement of C. pneumoniae in pathogenesis of lung cancer. We therefore investigated the presence of C. pneumoniae DNA in tumor lung tissues by using real-time PCR assay. Simultaneously, tumor and healthy tissues from the same patient with primary carcinoma lung were analyzed. C. pneumoniae DNA was not detected in a single lung tumor tissue by means of an highly sensitive, and specific real-time PCR assay based on FRET hybridization probes. In conclusion, this study does not support the involvement of C. pneumoniae in the pathogenesis of lung cancer, suggesting that further investigations are needed to clarify other potential causative factors for the development of this malignancy.

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confidence: 99%

No Evidence of Involvement ofChlamydia Pneumoniaein Lung Cancer by Means of Quantitative Real-Time Polymerase Chain Reaction

Sessa¹,

Santino²,

M³

et al. 2008

Int J Immunopathol Pharmacol

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“…chronic diseases has re-emerged. The involvement of C. pneumoniae in the pathogenesis of chronic extrapulmonary diseases is supported by direct detection of chlamydial DNA in cerebrospinal fluid of multiple sclerosis patients, brains of affected Alzheimer subjects, and in atherosclerotic lesions (4)(5)(6)(7). Of these chronic diseases, the strongest association has been with atherosclerosis in animal models, which provide causal evidence (8) and by direct detection of the microorganism in atherosclerotic lesions.…”

mentioning

confidence: 77%

“…Current opinion is that C. pneumoniae infection is implicated in several chronic extrapulmonary diseases such as atherosclerosis, multiple sclerosis, and Alzheimer's disease (1)(2)(3)(4)(5). However, association of C. pneumoniae with multiple sclerosis and Alzheimer's disease remains highly controversial, whereas that with atherosclerosis has gained much support over the past years.…”

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confidence: 99%

Chlamydia Pneumoniae and Chronic Diseases with a Great Impact on Public Health

Sessa

Cipriani

Pietro

et al. 2008

Int J Immunopathol Pharmacol

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Chlamydia pneumoniae is recognised as a common cause of respiratory tract infections and has recently been implicated in several extrapulmonary chronic diseases, with great impact on public health, such as atherosclerosis, multiple sclerosis and Alzheimer's disease. The involvement of C. pneumoniae in such diseases may be correlated to characteristic features of this pathogen, including intracellular growth and ability to induce persistent forms. C. pneumoniae persistent forms are inherently more suited to evade the host immune response and are more difficult to eradicate by antibiotics. Our preliminary experimental findings show that interaction of C. pneumoniae with macrophages and/or T cells characterized by interference with TNF-α production, and redox state, culminates in the induction of T cell apoptosis and survival of infected macrophages. Based on our evidence, the poor cooperation between T cells and macrophages could lead to an inappropriate immune response against C. pneumoniae that may therefore promote the development of extrapulmonary chronic diseases.

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“…In atherosclerosis, the involvement of e. pneumoniae, a respiratory pathogen, has been supported by seroepidemiology, identification of the microorganism within atheroma by immunochemistry and electron microscopy, and direct detection of chlamydial DNA within atheroma by polymerase chain reaction (PCR) (13)(14)(15). Several in vivo studies have shown that e. pneumoniae contributes to exacerbation of lesions in hyperlipidaemic animal models, suggesting thatthis microorganism is aco-risk factor with hyperlipidaemia (15).…”

Section: The Involvement Ofc Pneumoniae In Cardiovascular Diseasementioning

confidence: 99%

Chlamydia Pneumoniae and Cardiovascular Disease in End-Stage Renal Disease Patients: An Update

2013

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Cardiovascular diseases (CVD), due to accelerated atherosclerosis, are responsible for approximately 50% of mortality in End Stage Renal Disease (ESRD) patients undergoing haemodialysis (HD). Over the last decade, Chlamydia pneumoniae, a respiratory pathogen, has been involved in the pathogenesis of atherosclerosis and several reports have suggested the association between C. pneumoniae infection and CVD in HD patients. This report reviews the contribution of C. pneumoniae infection in cardiovascular diseases in ESRD patients, in light of recent studies on cardiovascular risk factors; we hypothesize that C. pneumoniae-infection may contribute to mineral bone disorder and, consequently, vascular calcification. However, further studies are needed to define the relationship between C pneumoniae and bone and vascular disorders in HD patients.

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Chlamydia Pneumoniae in Asymptomatic Carotid Atherosclerosis

Cited by 20 publications

References 33 publications

No Evidence of Involvement ofChlamydia Pneumoniaein Lung Cancer by Means of Quantitative Real-Time Polymerase Chain Reaction

No Evidence of Involvement ofChlamydia Pneumoniaein Lung Cancer by Means of Quantitative Real-Time Polymerase Chain Reaction

Chlamydia Pneumoniae and Chronic Diseases with a Great Impact on Public Health

Chlamydia Pneumoniae and Cardiovascular Disease in End-Stage Renal Disease Patients: An Update

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