Chitosonic® Acid as a Novel Cosmetic Ingredient: Evaluation of its Antimicrobial, Antioxidant and Hydration Activities

Abstract

Chitosonic® Acid, carboxymethyl hexanoyl chitosan, is a novel chitosan material that has recently been accepted by the Personal Care Products Council as a new cosmetic ingredient with the INCI (International Nomenclature of Cosmetic Ingredients) name Carboxymethyl Caprooyl Chitosan. In this study, we analyze several important cosmetic characteristics of Chitosonic® Acid. Our results demonstrate that Chitosonic® Acid is a water-soluble chitosan derivative with a high HLB value. Chitosonic® Acid can form a nano-network structure when its concentration is higher than 0.5% and can self-assemble into a nanosphere structure when its concentration is lower than 0.2%. Chitosonic® Acid has potent antimicrobial activities against gram-positive bacteria, gram-negative bacteria and fungus. Chitosonic® Acid also has moderate DPPH radical scavenging activity. Additionally, Chitosonic® Acid exhibits good hydration activity for absorbing and retaining water molecules with its hydrophilic groups. From a safety point of view, Chitosonic® Acid has no cytotoxicity to L-929 cells if its concentration is less than 0.5%. Moreover, Chitosonic® Acid has good compatibilities with various normal cosmetic ingredients. Therefore, we propose that Chitosonic® Acid has the potential to be a widely used ingredient in various types of cosmetic products.

Achillea millefolium L. Essential Oil Inhibits LPS-Induced Oxidative Stress and Nitric Oxide Production in RAW 264.7 Macrophages

“…The cells were treated with different concentrations (0, 20, 40 and 80 μg/mL) of essential oil and LPS (l μg/mL) and grown at 37 °C in 5% CO 2 and 95% air for 20 h. A MTT assay was used to determine cell viability [38]. …”

Chitosan Nanoparticles for Generating Novel Systems for Better Applications: A Review

“…A combination of the salt of pyrithione with chitosan was shown to be a slow release. Chitosonic® acid (Carboxymethyl Caprooyl Chitosan) can also be used in personal care products and Chitosonic® acid has recently been approved by the Personal Care Products Council as new cosmetic ingredient [72]. Interestingly, Chitosonic® acid is water soluble, can form a nano-network structure at concentration higher than 0.5% and can be made into nanosphere [72].…”

“…Chitosonic® acid (Carboxymethyl Caprooyl Chitosan) can also be used in personal care products and Chitosonic® acid has recently been approved by the Personal Care Products Council as new cosmetic ingredient [72]. Interestingly, Chitosonic® acid is water soluble, can form a nano-network structure at concentration higher than 0.5% and can be made into nanosphere [72]. Chitosonic® acid has antimicrobial activities, anti-oxidant function, possesses good hydration activity and has shown less cytotoxicity as tested in L-929 cells [72].…”

“…Interestingly, Chitosonic® acid is water soluble, can form a nano-network structure at concentration higher than 0.5% and can be made into nanosphere [72]. Chitosonic® acid has antimicrobial activities, anti-oxidant function, possesses good hydration activity and has shown less cytotoxicity as tested in L-929 cells [72]. Studies have shown that sulfated chitosan with varying molecular weights exhibited anti-coagulation activity similar to that of heparin [73].…”

Characterization of extracellular chitinase from Chitinibacter sp. GC72 and its application in GlcNAc production from crayfish shell enzymatic degradation

“…According to the 2012 National Bureau of Statistics data, in China, the production of shrimps and crabs was 6.14 × 10 6 t, with approximately 40-50% of the total mass considered as waste in the process of human consumption [6], causing a serious environmental problem. Consequently, numerous studies on the utilization of shell waste have been conducted [7][8][9][10], and among all the products extracted from shell waste, GlcNAc has attracted increasing attention due to its specific bioactivities, and has been widely used in many fields, including dietary supplements [11,12], cosmetics ingredients [13,14], and osteoarthritis therapeutics [15][16][17]. Moreover, with the improvement in people's living standard, the market demand for GlcNAc is gradually increasing and the production is estimated to reach 46,600 t by 2017 [18].…”