Chitosan - zeolite scaffold as a potential biomaterial in the controlled release of drugs for osteoporosis

Sandomierski, Mariusz; Adamska, Katarzyna; Ratajczak, Maria; Voelkel, Adam

doi:10.1016/j.ijbiomac.2022.11.071

Cited by 13 publications

(2 citation statements)

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“…The shape of the pore structure also influences bone integration and bone regeneration. Common pore shapes include spherical, rod-shaped, and sheet-shaped shapes 112 . Different pore shapes can affect the attachment and arrangement of bone cells, as well as the mechanical properties and biodegradation rate of materials.…”

Section: Biophysical Stimulation For Osteoporotic Osseointegration An...mentioning

confidence: 99%

Osteoporotic osseointegration: therapeutic hallmarks and engineering strategies

Chen,

Hao,

et al. 2024

Theranostics

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Osteoporosis is a systemic skeletal disease caused by an imbalance between bone resorption and formation. Current treatments primarily involve systemic medication and hormone therapy. However, these systemic treatments lack directionality and are often ineffective for locally severe osteoporosis, with the potential for complex adverse reactions. Consequently, treatment strategies using bioactive materials or external interventions have emerged as the most promising approaches. This review proposes twelve microenvironmental treatment targets for osteoporosis-related pathological changes, including local accumulation of inflammatory factors and reactive oxygen species (ROS), imbalance of mitochondrial dynamics, insulin resistance, disruption of bone cell autophagy, imbalance of bone cell apoptosis, changes in neural secretions, aging of bone cells, increased local bone tissue vascular destruction, and decreased regeneration. Additionally, this review examines the current research status of effective or potential biophysical and biochemical stimuli based on these microenvironmental treatment targets and summarizes the advantages and optimal parameters of different bioengineering stimuli to support preclinical and clinical research on osteoporosis treatment and bone regeneration. Finally, the review addresses ongoing challenges and future research prospects.

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Section: Biophysical Stimulation For Osteoporotic Osseointegration An...mentioning

confidence: 99%

Osteoporotic osseointegration: therapeutic hallmarks and engineering strategies

Chen,

Hao,

et al. 2024

Theranostics

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“…Tabela 13 -Relação entre os números de onda e os grupos funcionais referentes aos resultados observados na espectroscopia de infravermelho nos scaffolds híbridos de gelatina/xerogel de tanino-glutaraldeído (GT) A vibração de estiramento C -O da estrutura do sacarídeo, está refletida nas bandas de absorção em 896 cm -1 e uma curva mais ampla em torno de 1024 cm -1 . Essas bandas e picos característicos da quitosana no espectro FTIR confirmam a presença desse polissacarídeo nos scaffolds C1 e C2 (RESSLER et al, 2023;SANDOMIERSKI et al, 2022). Na Tabela 14, estão expostos resumidamente os dados das bandas e picos dos scaffolds C1 e C2.…”

Section: Espectroscopia De Infravermelho Com Transformada De Fourier ...unclassified

Desenvolvimento de >i<scaffolds>/i< de quitosana/gelatina/xerogel de tanino-glutaraldeído para aplicação em engenharia de tecidos

Cesquim

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Fabrication of porous poly(L‐lactide‐co‐ε‐caprolactone) micropowder for microbubble effect and ultrasound‐mediated drug delivery

Lim

2024

Biopolymers

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Biodegradable elastic poly(L‐lactide‐co‐ε‐caprolactone) (PLCL) copolymer (50:50, lactide:caprolactone molar ratio) was synthesized and porous PLCL micropowders was fabricated by a simple method involving rapid cooling of 0.1, 0.5, and 1% (wt/vol) PLCL/dioxane spray into liquid nitrogen. The physicochemical properties of the porous PLCL micropowders were examined by measuring their pore size, pore morphology, and microbead size using a scanning electron microscopy (SEM) and dye and temozolomide (TMZ)‐release testing under ultrasound. Human U‐87MG, glioblastoma (GBM) cell culture tests were performed to evaluate cell cytotoxicity by released drug from PLCL micropowders. In this study, the porous PLCL micropowders prepared from 1 wt%/vol% PLCL solutions showed a highly porous structure, satisfactory mechanical properties, and optimal drug release efficiency compared with those produced from 0.1 or 0.5 wt%/vol% solutions. The results of the accumulated release test with the results of the absorbance of the dye initially applied, it was confirmed that more than 80% of the added dye was trapped inside the micropowder, and clearly GBM cytotoxicity effect could be observed by the released TMZ. The drug release system using micropowders and ultrasound can be applied as a drug supply system for various diseases such as brain tumors with low drug permeability.

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Chitosan - zeolite scaffold as a potential biomaterial in the controlled release of drugs for osteoporosis

Cited by 13 publications

References 50 publications

Osteoporotic osseointegration: therapeutic hallmarks and engineering strategies

Osteoporotic osseointegration: therapeutic hallmarks and engineering strategies

Desenvolvimento de >i<scaffolds>/i< de quitosana/gelatina/xerogel de tanino-glutaraldeído para aplicação em engenharia de tecidos

Fabrication of porous poly(L‐lactide‐co‐ε‐caprolactone) micropowder for microbubble effect and ultrasound‐mediated drug delivery

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