Chitosan/Silver Nanoparticle/Graphene Oxide Nanocomposites with Multi-Drug Release, Antimicrobial, and Photothermal Conversion Functions

Abstract

In this work, we designed and fabricated a multifunctional nanocomposite system that consists of chitosan, raspberry-like silver nanoparticles, and graphene oxide. The room temperature atmospheric pressure microplasma (RT-APM) process provides a rapid, facile, and environmentally-friendly method for introducing silver nanoparticles into the composite system. Our composite can achieve a pH controlled single and/or dual drug release. Under pH 7.4 for methyl blue loaded on chitosan, the drug release profile features a burst release during the first 10 h, followed by a more stabilized release of 70–80% after 40–50 h. For fluorescein sodium loaded on graphene oxide, the drug release only reached 45% towards the end of 240 h. When the composite acted as a dual drug release system, the interaction of fluorescein sodium and methyl blue slowed down the methyl blue release rate. Under pH 4, both single and dual drug systems showed a much higher release rate. In addition, our composite system demonstrated strong antibacterial abilities against E. coli and S. aureus, as well as an excellent photothermal conversion effect under irradiation of near infrared lasers. The photothermal conversion efficiency can be controlled by the laser power. These unique functionalities of our nanocomposite point to its potential application in multiple areas, such as multimodal therapeutics in healthcare, water treatment, and anti-microbials, among others.

Preparation and characterisation of ciprofloxacin‐loaded silver nanoparticles for drug delivery

“…Then, the release from Cipro‐AgNPs nanocomposites increases steeply, reaching 98% after 770 min. In this work, the first fast step of the release profile may be due to the release of the Cipro drug that is free on the surface of the AgNPs [41, 42]. The release in the slow second step is due to anion exchange between Cipro and phosphate anions in the release media.…”

AuNP/Chitosan Nanocomposites Synthesized through Plasma Induced Liquid Chemistry and Their Applications in Photothermal Induced Bacteria Eradication

“…For HAuCl 4 /CS mixture solution, the corresponding absorption peaks showed decreased intensity and were red shifted, indicating part of [AuCl 4 ] − were anchored onto the CS ( Figure S2 -red curve) [ 48 ]. This transition can be attributed to the interaction between [AuCl 4 ] − complex and the CS -NH 2 group through ion exchanging reaction as -NH 2 becomes ionized into -NH − and H + in water [ 49 ]. In contrast, no ion exchange should in principle take place between -OH and [AuCl 4 ] − because −OH cannot be ionized in water [ 34 ] ( Scheme 2 ).…”

Preparation, Characterization, and Evaluation of Curcumin–Graphene Oxide Complex-Loaded Liposomes against Staphylococcus aureus in Topical Disease

“…Using liposomes in topical drug delivery systems has become more popular because of their amphiphilic character, which makes them an excellent penetration enhancer for the cutaneous drug delivery of various phytoactives including curcumin . According to the literature, the loading of various phytoactives with GO has been available for various therapeutics. ,− In our experiment, CUR with the GO complex has been developed, and further, it is loaded into the liposomes. The complex formation resulted in a ratio of 1:1 (CUR: GO), as shown in Figure S1.…”