Chitosan Polymer as a Coat of Calcium Alginate Microcapsules Loaded by Non-Steroidal Antiinflammatory Drug

Abstract

In a trial to delay the release rate of diclofenac sodium from alginate coated microcapsules, the use of a copolymer was suggested. Mixtures of polymers can have a significant properties than that of individual polymer to achieve sustained release microcapsules. On considering the negative charge of alginate and its ability to form polyionic complexes with a lowered tendency of erosion at higher pH value, a cationic polymer was seeked. Chitosan (CS) was the one of choice due to the similarity of the saccharide structures of chitosan and alginate that offers greater interaction between the two polymers and stronger inter-chains reactions relative to that between alginate and branched polymers such as polylysine. The microcapsules prepared using 0.1 and 0.25% (CS) were spherical in shape while 0.4% (CS) formed microcapsules having rounded heads and tapered tails. The change in chitosan concentration had a non-significant effect on the particle size, the yield and the drug loading efficiency. The releaser ate of diclofenac sodium from microspheres showed a pHdependent profile and was affected by chitosan coating. The release rate of diclofenac sodium from chitosan coated alginate microcapsules at pH 7.4 was found to be faster than its release at pH 1.2. These results suggest this coating method to protect diclofenac sodium under acidic conditions and to permit a complete but controlled release of diclofenac sodium.

Tailoring of Novel Azithromycin-Loaded Zinc Oxide Nanoparticles for Wound Healing

“…This AZM monolayer adhesion had a deleterious impact on drug release from the ZnONP surface. The quantity of drug adsorbed in a multilayer pattern on the surface of ZnONPs, which made it more easily released because of attachment forces, decreased whenever the ZnONP weight was lowered [27,68].…”

Novel Green Biosynthesis of 5-Fluorouracil Chromium Nanoparticles Using Harpullia pendula Extract for Treatment of Colorectal Cancer

“…The reasons behind the use of this methodology include the fact it is centered around the use of environmentally friendly, financially savvy, and biocompatible lessening specialists for the combination of nanoparticles [ 27 , 28 ]. Members of the genus Harpullia are known to be rich sources of saponins, triterpenes, tannins, flavonoids, and sterols [ 29 , 30 , 31 , 32 , 33 , 34 ].…”

Design and Optimization of Orally Administered Luteolin Nanoethosomes to Enhance Its Anti-Tumor Activity against Hepatocellular Carcinoma

“…Statistical analysis, response surface methodology, and factorial optimization of the data were attained using MiniTab 17 software (San Diego, CA, USA). Data evaluations were completed using analysis of variance (ANOVA) followed by Tokay’s t -test [ 12 , 43 ]. Statistical significance was acceptable to a level of p < 0.05 and all relevant results were graphically displayed as mean ± SD.…”