Chitosan-poly(lactide-co-glycolide)/poloxamer mixed micelles as a mucoadhesive thermo-responsive moxifloxacin eye drop to improve treatment efficacy in bacterial keratitis

Ch, Sanjay; Padaga, Sri Ganga; Ghosh, Balaram; Roy, Sanhita; Biswas, Swati

doi:10.1016/j.carbpol.2023.120822

Cited by 15 publications

(5 citation statements)

References 60 publications

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“…To evaluate the influence of the VES-GEM conjugate on the self-assembly of Pluronic F68 ® (CMC 0.48 mM) and Pluronic ® F127 (CMC 0.0028 mM) micelles, a surface tension assay was carried out [ 64 ]. Briefly, two stock solutions of VES-GEM in ethanol (500 µL, 37.24 mg/mL, and 500 µL; 2.173 × 10 −1 mg/mL) were prepared, for a CMC assay of Pluronic F68 ® and Pluronic ® F127, respectively, and aliquots (50 µL) were added to Eppendorf vials.…”

Section: Methodsmentioning

confidence: 99%

Gemcitabine-Vitamin E Prodrug-Loaded Micelles for Pancreatic Cancer Therapy

Pereira-Silva,

Miranda-Pastoriza,

Diaz-Gomez

et al. 2024

Pharmaceutics

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Pancreatic cancer (PC) is an aggressive cancer subtype presenting unmet clinical challenges. Conventional chemotherapy, which includes antimetabolite gemcitabine (GEM), is seriously undermined by a short half-life, its lack of targeting ability, and systemic toxicity. GEM incorporation in self-assembled nanosystems is still underexplored due to GEM’s hydrophilicity which hinders efficient encapsulation. We hypothesized that vitamin E succinate–GEM prodrug (VES-GEM conjugate) combines hydrophobicity and multifunctionalities that can facilitate the development of Pluronic®F68 and Pluronic®F127 micelle-based nanocarriers, improving the therapeutic potential of GEM. Pluronic®F68/VES-GEM and Pluronic®F127/VES-GEM micelles covering a wide range of molar ratios were prepared by solvent evaporation applying different purification methods, and characterized regarding size, charge, polydispersity index, morphology, and encapsulation. Moreover, the effect of sonication and ultrasonication and the influence of a co-surfactant were explored together with drug release, stability, blood compatibility, efficacy against tumour cells, and cell uptake. The VES-GEM conjugate-loaded micelles showed acceptable size and high encapsulation efficiency (>95%) following an excipient reduction rationale. Pluronic®F127/VES-GEM micelles evidenced a superior VES-GEM release profile (cumulative release > 50%, pH = 7.4), stability, cell growth inhibition (<50% cell viability for 100 µM VES-GEM), blood compatibility, and extensive cell internalization, and therefore represent a promising approach to leveraging the efficacy and safety of GEM for PC-targeted therapies.

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Section: Methodsmentioning

confidence: 99%

Gemcitabine-Vitamin E Prodrug-Loaded Micelles for Pancreatic Cancer Therapy

Pereira-Silva,

Miranda-Pastoriza,

Diaz-Gomez

et al. 2024

Pharmaceutics

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“…Chemical polymerization of PPy particles using these medication loaded SDBS micelles forms systems capable of regulating medication release in various scenarios, including chronic retinal diseases (Uppalapati et al, 2018). Table 1 provides a summary of eye-responsive drug delivery systems reported in recent literature (Jaiswal, Kumar, and Pathak, 2015;Chen et al, 2018;Devi et al, 2019;Wang et al, 2020;Hamed et al, 2022;Ch et al, 2023).…”

Section: Intelligent Polymer Nanomicelles Delivery Systemmentioning

confidence: 99%

“…Bacterial keratitis is a rapidly evolving corneal ulceration that endangers vision, necessitating swift and efficient treatment. Sanjay (Ch et al, 2023) devised chitosan-poly (lactide-co-glycolide)/ poloxamer mixed micelles functioning as mucoadhesive thermos responsive moxifloxacin eye drops to evaluate its therapeutic efficacy against bacterial keratitis. Human corneal epithelial (HCE) cells and goat corneas were used for in vitro and in vivo simulation experiments, respectively.…”

Section: Bacterial Infectionsmentioning

confidence: 99%

Recent development of polymer nanomicelles in the treatment of eye diseases

Cai

Zhang

Hao

2023

Front. Bioeng. Biotechnol.

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The eye, being one of the most intricate organs in the human body, hosts numerous anatomical barriers and clearance mechanisms. This highlights the importance of devising a secure and efficacious ocular medication delivery system. Over the past several decades, advancements have been made in the development of a nano-delivery platform based on polymeric micelles. These advancements encompass diverse innovations such as poloxamer, chitosan, hydrogel-encapsulated micelles, and contact lenses embedded with micelles. Such technological evolutions allow for sustained medication retention and facilitate enhanced permeation within the eye, thereby standing as the avant-garde in ocular medication technology. This review provides a comprehensive consolidation of ocular medications predicated on polymer nanomicelles from 2014 to 2023. Additionally, it explores the challenges they pose in clinical applications, a discussion intended to aid the design of future clinical research concerning ocular medication delivery formulations.

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“…18,19 The thermoresponsive properties of chitosan are exploited to fabricate an injectable hydrogel that is in the liquid phase at room temperature but the gel phase at body temperature, which has advantages in osteogenesis and wound healing applications. 20,21 The shape-memory characteristic of chitosan allows the development of a self-healing hydrogel for dynamic wound applications and shape-memory scaffolds to minimize invasive bone surgery, treating deep penetrating wounds, and synthesizing self-healing wound dressings. 22,23 Considering research on chitosan-based smart biomaterial has grown rapidly in the past decades with many biomedical applications, researchers need an up-to-date review that discusses not only chitosan-based traditional biomaterials but also chitosan-based smart biomaterials.…”

Section: Introductionmentioning

confidence: 99%

“…Among various materials discussed previously, chitosan has shown its distinct position in the biomedical field because the presence of amino and hydroxyl groups allows chitosan to be modified: it has many smart characteristics such as pH-responsive, thermoresponsive, shape memory, and (bio)chemicals-responsive . pH-responsive materials are very useful for targeted drug delivery application, which can minimize the side effect suffered by the patient during the medication process. , The thermoresponsive properties of chitosan are exploited to fabricate an injectable hydrogel that is in the liquid phase at room temperature but the gel phase at body temperature, which has advantages in osteogenesis and wound healing applications. , The shape-memory characteristic of chitosan allows the development of a self-healing hydrogel for dynamic wound applications and shape-memory scaffolds to minimize invasive bone surgery, treating deep penetrating wounds, and synthesizing self-healing wound dressings. , …”

Section: Introductionmentioning

confidence: 99%

Chitosan-Based Smart Biomaterials for Biomedical Applications: Progress and Perspectives

Budiarso,

Rini,

Tsalsabila

et al. 2023

ACS Biomater. Sci. Eng.

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Over the past decade, smart and functional biomaterials have escalated as one of the most rapidly emerging fields in the life sciences because the performance of biomaterials could be improved by careful consideration of their interaction and response with the living systems. Thus, chitosan could play a crucial role in this frontier field because it possesses many beneficial properties, especially in the biomedical field such as excellent biodegradability, hemostatic properties, antibacterial activity, antioxidant properties, biocompatibility, and low toxicity. Furthermore, chitosan is a smart and versatile biopolymer due to its polycationic nature with reactive functional groups that allow the polymer to form many interesting structures or to be modified in various ways to suit the targeted applications. In this review, we provide an up-to-date development of the versatile structures of chitosan-based smart biomaterials such as nanoparticles, hydrogels, nanofibers, and films, as well as their application in the biomedical field. This review also highlights several strategies to enhance biomaterial performance for fast growing fields in biomedical applications such as drug delivery systems, bone scaffolds, wound healing, and dentistry.

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Chitosan-poly(lactide-co-glycolide)/poloxamer mixed micelles as a mucoadhesive thermo-responsive moxifloxacin eye drop to improve treatment efficacy in bacterial keratitis

Cited by 15 publications

References 60 publications

Gemcitabine-Vitamin E Prodrug-Loaded Micelles for Pancreatic Cancer Therapy

Gemcitabine-Vitamin E Prodrug-Loaded Micelles for Pancreatic Cancer Therapy

Recent development of polymer nanomicelles in the treatment of eye diseases

Chitosan-Based Smart Biomaterials for Biomedical Applications: Progress and Perspectives

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