Recent development of polymer nanomicelles in the treatment of eye diseases

Cai, Rong; Zhang, Ling; Hao, Changfu

doi:10.3389/fbioe.2023.1246974

Cited by 10 publications

(5 citation statements)

References 141 publications

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“…Nanomicelles are amphiphilic molecules that spontaneously form spheres due to non-covalent interactions, with the hydrophilic heads facing outward and the hydrophobic tails facing inward, and which can deliver therapeutics to the eye, including drugs and gene vectors [11,189,190]. The hydrophobic tails of micelles can be chemically modified to increase their interaction with specific drugs [11].…”

Section: Nanomicellesmentioning

confidence: 99%

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Seeing the Future: A Review of Ocular Therapy

Whalen,

Akula,

McNamee

et al. 2024

Bioengineering

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Ocular diseases present a unique challenge and opportunity for therapeutic development. The eye has distinct advantages as a therapy target given its accessibility, compartmentalization, immune privilege, and size. Various methodologies for therapeutic delivery in ocular diseases are under investigation that impact long-term efficacy, toxicity, invasiveness, and delivery range. While gene, cell, and antibody therapy and nanoparticle delivery directly treat regions that have been damaged by disease, they can be limited in the duration of the therapeutic delivery and have a focal effect. In contrast, contact lenses and ocular implants can more effectively achieve sustained and widespread delivery of therapies; however, they can increase dilution of therapeutics, which may result in reduced effectiveness. Current therapies either offer a sustained release or a broad therapeutic effect, and future directions should aim toward achieving both. This review discusses current ocular therapy delivery systems and their applications, mechanisms for delivering therapeutic products to ocular tissues, advantages and challenges associated with each delivery system, current approved therapies, and clinical trials. Future directions for the improvement in existing ocular therapies include combination therapies, such as combined cell and gene therapies, as well as AI-driven devices, such as cortical implants that directly transmit visual information to the cortex.

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Section: Nanomicellesmentioning

confidence: 99%

“…PEG nanomicelle formulations show potential toxic effects [191] when compared with natural formulations such as chitosan. However, some synthetic nanomicelles, such as PLLA, PGA, and PCL, are also biocompatible and break down into non-toxic byproducts, resulting in their FDA approval [189].…”

Section: Nanomicellesmentioning

confidence: 99%

Seeing the Future: A Review of Ocular Therapy

Whalen,

Akula,

McNamee

et al. 2024

Bioengineering

View full text Add to dashboard Cite

show abstract

“…They can release drugs in response to endogenous or exogenous stimuli and are often used to deliver poorly water-soluble drugs to the eye. 82 A novel eye drop formulation in which nifedipine (NFP) is encapsulated in nanomicelles was proposed to prevent the formation and early progression of oxidative cataracts. The NFP-loaded micelles demonstrated good biocompatibility and bioavailability.…”

Section: Nanomicellesmentioning

confidence: 99%

Breaking Barriers: Nanomedicine-Based Drug Delivery for Cataract Treatment

Chen,

Ye,

Chen

et al. 2024

IJN

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Cataract is a leading cause of blindness globally, and its surgical treatment poses a significant burden on global healthcare. Pharmacologic therapies, including antioxidants and protein aggregation reversal agents, have attracted great attention in the treatment of cataracts in recent years. Due to the anatomical and physiological barriers of the eye, the effectiveness of traditional eye drops for delivering drugs topically to the lens is hindered. The advancements in nanomedicine present novel and promising strategies for addressing challenges in drug delivery to the lens, including the development of nanoparticle formulations that can improve drug penetration into the anterior segment and enable sustained release of medications. This review introduces various cutting-edge drug delivery systems for cataract treatment, highlighting their physicochemical properties and surface engineering for optimal design, thus providing impetus for further innovative research and potential clinical applications of anti-cataract drugs.

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“…Certain polymers exhibit temperature-sensitive behavior, undergoing phase transitions or changes in solubility at specific temperatures. Polymers like poly(N-isopropylacrylamide) (PNIPAM) transition from a hydrophilic to a hydrophobic state at their lower critical solution temperature (LCST), leading to drug release [ 305 ]. These polymeric nanoparticles can be engineered to release drugs when the local temperature is raised.…”

Section: Current Trends In Modern Nanopharmaceuticals´ Designmentioning

confidence: 99%

Nanoformulations in Pharmaceutical and Biomedical Applications: Green Perspectives

Petrovic,

Bita,

Barbinta-Patrascu

2024

IJMS

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This study provides a brief discussion of the major nanopharmaceuticals formulations as well as the impact of nanotechnology on the future of pharmaceuticals. Effective and eco-friendly strategies of biofabrication are also highlighted. Modern approaches to designing pharmaceutical nanoformulations (e.g., 3D printing, Phyto-Nanotechnology, Biomimetics/Bioinspiration, etc.) are outlined. This paper discusses the need to use natural resources for the “green” design of new nanoformulations with therapeutic efficiency. Nanopharmaceuticals research is still in its early stages, and the preparation of nanomaterials must be carefully considered. Therefore, safety and long-term effects of pharmaceutical nanoformulations must not be overlooked. The testing of nanopharmaceuticals represents an essential point in their further applications. Vegetal scaffolds obtained by decellularizing plant leaves represent a valuable, bioinspired model for nanopharmaceutical testing that avoids using animals. Nanoformulations are critical in various fields, especially in pharmacy, medicine, agriculture, and material science, due to their unique properties and advantages over conventional formulations that allows improved solubility, bioavailability, targeted drug delivery, controlled release, and reduced toxicity. Nanopharmaceuticals have transitioned from experimental stages to being a vital component of clinical practice, significantly improving outcomes in medical fields for cancer treatment, infectious diseases, neurological disorders, personalized medicine, and advanced diagnostics. Here are the key points highlighting their importance. The significant challenges, opportunities, and future directions are mentioned in the final section.

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Recent development of polymer nanomicelles in the treatment of eye diseases

Cited by 10 publications

References 141 publications

Seeing the Future: A Review of Ocular Therapy

Seeing the Future: A Review of Ocular Therapy

Breaking Barriers: Nanomedicine-Based Drug Delivery for Cataract Treatment

Nanoformulations in Pharmaceutical and Biomedical Applications: Green Perspectives

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