Chitosan oligosaccharide enhances binding of nanostructured lipid carriers to ocular mucins: Effect on ocular disposition

Pai, Rohan; Vavia, Pradeep R.

doi:10.1016/j.ijpharm.2020.119095

Cited by 47 publications

(20 citation statements)

References 44 publications

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“…According to curcumin release studies, NACCS showed a remarkably slower drug release compared to the other two coatings, which was probably due to the formation of disulfide bonds within the coating, impeding the diffusion of the drug. CS oligosaccharides showed a faster release compared to the thiolated CS coating; however, in contrast to Pai et al [309], it was still slower than uncoated NLC. Finally, carboxymethyl CS showed the fastest release of all the coated NPs.…”

Section: Chitosan Coatingscontrasting

confidence: 65%

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Chitosan and its Derivatives for Ocular Delivery Formulations: Recent Advances and Developments

et al. 2020

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Chitosan (CS) is a hemi-synthetic cationic linear polysaccharide produced by the deacetylation of chitin. CS is non-toxic, highly biocompatible, and biodegradable, and it has a low immunogenicity. Additionally, CS has inherent antibacterial properties and a mucoadhesive character and can disrupt epithelial tight junctions, thus acting as a permeability enhancer. As such, CS and its derivatives are well-suited for the challenging field of ocular drug delivery. In the present review article, we will discuss the properties of CS that contribute to its successful application in ocular delivery before reviewing the latest advances in the use of CS for the development of novel ophthalmic delivery systems. Colloidal nanocarriers (nanoparticles, micelles, liposomes) will be presented, followed by CS gels and lenses and ocular inserts. Finally, instances of CS coatings, aiming at conferring mucoadhesiveness to other matrixes, will be presented.

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Section: Chitosan Coatingscontrasting

confidence: 65%

“…Pai et al used CS oligosaccharide in order to coat NLCs for the delivery of etoposide, which is an antineoplastic agent used for suppressing tumors that occur in the eye such as retinoblastoma [309]. NLCs were prepared via a hot homogenization-ultrasonication technique, and the resulting NPs were coated by CS oligosaccharides.…”

Section: Chitosan Coatingsmentioning

confidence: 99%

Chitosan and its Derivatives for Ocular Delivery Formulations: Recent Advances and Developments

et al. 2020

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“…The anatomical barriers consist of the blood-aqueous barrier, the strongly vascularized choroid, which allows the rapid clearance of drugs, the corneal barriers and the retinal pigment epithelium, which is also considered the blood-brain barrier equivalent of the eye. The physiological barriers include the presence of a mucin and tear layer which determine the rapid drug removal as a result of drainage of the fluid tears in the nasolacrimal duct induced by blinking [109].…”

Section: Chitosan Based Nanomaterials As Transmucosal Nanocarriersmentioning

confidence: 99%

Recent Biomedical Approaches for Chitosan Based Materials as Drug Delivery Nanocarriers

et al. 2021

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In recent decades, drug delivery systems (DDSs) based on nanotechnology have been attracting substantial interest in the pharmaceutical field, especially those developed based on natural polymers such as chitosan, cellulose, starch, collagen, gelatin, alginate and elastin. Nanomaterials based on chitosan (CS) or chitosan derivatives are broadly investigated as promising nanocarriers due to their biodegradability, good biocompatibility, non-toxicity, low immunogenicity, great versatility and beneficial biological effects. CS, either alone or as composites, are suitable substrates in the fabrication of different types of products like hydrogels, membranes, beads, porous foams, nanoparticles, in-situ gel, microparticles, sponges and nanofibers/scaffolds. Currently, the CS based nanocarriers are intensely studied as controlled and targeted drug release systems for different drugs (anti-inflammatory, antibiotic, anticancer etc.) as well as for proteins/peptides, growth factors, vaccines, small DNA (DNAs) and short interfering RNA (siRNA). This review targets the latest biomedical approaches for CS based nanocarriers such as nanoparticles (NPs) nanofibers (NFs), nanogels (NGs) and chitosan coated liposomes (LPs) and their potential applications for medical and pharmaceutical fields. The advantages and challenges of reviewed CS based nanocarriers for different routes of administration (oral, transmucosal, pulmonary and transdermal) with reference to classical formulations are also emphasized.

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“…Confocal laser-scanning microscopy (CLSM) was used to evaluate the ability of the tested formulations to boost drug corneal permeation, 48 in addition to demonstrating the ocular mucoadhesion of uncoated NLCs and the two selected Epl-loaded MNLCs. 49 They were evaluated by imaging the intensity of RhB and its depth at the surface of the eye using CLSM (Carl Zeiss LSM 710, differential interference contrast, fluorescence, and bright field). The three groups of male albino rabbits were used for evaluating each system (uncoated NLCs and the two selected Eplloaded MNLCs).…”

Section: Transcorneal Visualizationmentioning

confidence: 99%

“…At predetermined time intervals after instillation (1, 2, 4, and 6 hours), the rabbits were euthanized with an intravenous injection of an overdose of sodium pentobarbital, given via a marginal ear vein, and the corneas removed, and fixed in physiological saline. The fluorescence intensity of RhB in the cornea was calculated after examination of the cornea using CLSM by taking mean intensity as the parameter, 49 and confocal images were managed and fixed. 50 Evaluation began from the outer corneal surface with the z-stack mode in the directions xy and xz.…”

Section: Transcorneal Visualizationmentioning

confidence: 99%

Effective Ocular Delivery of Eplerenone Using Nanoengineered Lipid Carriers in Rabbit Model

Abdelhakeem¹,

El-Nabarawi²,

Shamma³

2021

IJN

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Background: Eplerenone (Epl) is a selective mineralocorticoid-receptor antagonist used for chronic central serous chorioretinopathy treatment. Our goal was to enhance the corneal performance of Epl-loaded nanostructured lipid carriers (NLCs) through surface modification using different coating polymers. Methods: Epl-loaded modified NLCs (Epl-loaded MNLCs) were prepared by coating the surface of Epl-loaded NLCs using different polymers, namely hyaluronic acid, chitosan oligosaccharide lactate, and hydrogenated collagen. A 3 1 ×4 1 full factorial design was used to evaluate the effect of the surface modification on the properties of the prepared systems. Selected optimal Epl-loaded MNLCs were further evaluated for in vitro drug release, morphology, pH, rheological properties, corneal mucoadhesion, irritation, and penetration. Results: Epl-loaded MNLCs were successfully prepared with high drug-entrapment efficiency and nanosized particles with low size distribution. Transmission electron microscopy revealed nanosized spherical particles surrounded by a coating layer of the surface modifier. The pH, refractive index, and viscosity results of the Epl-loaded MNLCs confirmed the ocular compatibility of the systems with no blurring of vision. The safety and ocular tolerance of the optimal MNLCs were confirmed using the hen's egg test on chorioallantoic membrane and by histopathological evaluation of rabbit eyes treated with the optimal systems. Confocal laser-scanning microscopy of corneal surfaces confirmed successful transcorneal permeation of the Epl-loaded MNLCs compared to the unmodified Epl-loaded NLCs, revealed by higher corneal fluorescence intensity at all time intervals. Conclusion: Overall, the results confirmed the potential of Epl-loaded MNLCs as a direct approach for Epl ocular delivery.

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Chitosan oligosaccharide enhances binding of nanostructured lipid carriers to ocular mucins: Effect on ocular disposition

Cited by 47 publications

References 44 publications

Chitosan and its Derivatives for Ocular Delivery Formulations: Recent Advances and Developments

Chitosan and its Derivatives for Ocular Delivery Formulations: Recent Advances and Developments

Recent Biomedical Approaches for Chitosan Based Materials as Drug Delivery Nanocarriers

Effective Ocular Delivery of Eplerenone Using Nanoengineered Lipid Carriers in Rabbit Model

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