Chitosan nanoparticles loaded with dorzolamide and pramipexole

Papadimitriou, Sofia; Bikiaris, Dimitrios N.; Avgoustakis, Konstantinos; Karavas, Evangelos; Georgarakis, M.

doi:10.1016/j.carbpol.2007.11.007

Cited by 263 publications

(130 citation statements)

References 48 publications

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“…Due to C-C, C-O, C-H, and O-H stretching vibrations, peaks at 996, 1450, 2972 and 3569 cm −1 appeared in the FTIR spectrum of linalool respectively. After linalool was encapsulated, FTIR spectrum of Lin-nanocapsules showed that the characteristic absorption peaks at 3569 and 1450 cm −1 disappeared, and a peak appeared at 1098 cm −1 due to the phosphoric acid root and the protonation of amino cross linking effect (Papadimitriou et al, 2008). Peak types of Lin-nanocapsules and blank nanocapsules were similar.…”

Section: Ftir Resultsmentioning

confidence: 89%

Production and characterization of nanocapsules encapsulated linalool by ionic gelation method using chitosan as wall material

Xiao

Zhu

2017

Food Sci. Technol

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Linalool has been extensively applied in various fields, such as flavoring agent, perfumes, cosmetics and medical science. However, linalool is unstable, volatile and readily oxidizable. A sensitive substance can be encapsulated in a capsule, so encapsulation technology can solve these problems. In this paper, linalool-loaded nanocapsules (Lin-nanocapsules) were prepared via the ionic gelation method and Lin-nanocapsules were characterized. The results of Fourier transformation infrared spectroscopy (FTIR) showed that linalool was successfully encapsulated in the wall materials. Scanning electron microscopy (SEM) results demonstrated that the shapes of Lin-nanocapsules, with smooth surfaces, were nearly spherical. Lin-nanocapsule average particle size was 352 nm and its polydispersity index (PDI) was proved to be 0.214 by the results of dynamic light scattering (DLC). Thermogravimetric results indicated that linalool loading capacity (LC) was 15.17%, and encapsulation could decrease linalool release and increase linalool retaining time under the high temperature. Oscillatory shear and steady-state shear measurements of Lin-nanocapsule emulsions were systematically investigated. The results of steady-state shear showed that Lin-nanocapsule emulsion, which was Newtonian only for high shear rate, was non-Newtonian. It was proved by oscillatory shear that when oscillation frequency changed from low to high, Lin-nanocapsules emulsion changed from viscous into elastic.Keywords: lin-nanocapsules; flavor; encapsulation; rheology.Practical Application: Lin-nanocapsules were prepared via the ionic gelation method.

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Section: Ftir Resultsmentioning

confidence: 89%

Production and characterization of nanocapsules encapsulated linalool by ionic gelation method using chitosan as wall material

Xiao

Zhu

2017

Food Sci. Technol

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“…The test bacterium taken from an overnight culture (inoculated from a single colony) was freshly grown for 4 Vancomycin disc was obtained commercially from Himedia and CMC-EDBE-FA nanoparticle discs were prepared according to the standard method [12] . The diameter of zone of bacterial growth inhibition surrounding the disc (including the disc), was measured and compared with vancomycin standard.…”

Section: Disc Agar Diffusion (Dad) Testmentioning

confidence: 99%

“…Utilization of CS derived from crustacean shells may cause hypersensitivity reactions in individual with shellfish allergy [2] . Carboxymethyl chitosan (CMC) is a linear polysaccharide composed of 毬 (1,4) glycosidic linkages between 6-carboxymethyl-D-glucosamine monomers. CMC is synthesized from CS by carboxylation of the hydroxyl and amine groups.…”

Section: Introductionmentioning

confidence: 99%

“…Amino and carboxyl functional group of CMC can serve as chelation sites and form complexes with pharmaceuticals [3] . CMC demonstrates potential applications in biotechnology, biomedicine, food ingredients and cosmetics [4,5] . In our previous laboratory report, we synthesized carboxymethyl chitosan-2, 2' ethylenedioxy bis-ethylamine-folate (CMC-EDBE-FA) nanoparticle based on carboxy methyl chitosan tagged with folic acid by covalently linkage through 2, 2' (ethylenedioxy) bis- (ethylamine) and established that it has no toxic effect [6,7] .…”

Section: Introductionmentioning

confidence: 99%

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Biocompatibility of folate–modified chitosan nanoparticles

Chakraborty

Sahu

Pramanik

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

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“…It was explained previously that the intrinsic positive charge on CS nanoparticles led to the increased FPF of nanoparticles with increasing surface charge due to repulsive force among particles that formed loose agglomerates; however, the dispersibility from large carrier based formulation was not in conformity with this argument. Once aerosolised the formulation, the agglomerates may be subjected to kinetic forces due to inspiratory flow and inhaler mechanical impaction forces or a combination of both for appropriate deagglomeration and subsequent dispersion (Al-Qadi et al, 2012;Leung et al, 2015;Papadimitriou et al, 2008). The SEM images in Figure 4.10 showed nanoparticles were distributed either as agglomerates or as a single particle on the large lactose carriers.…”

Section: Formulations With Large Carriermentioning

confidence: 99%

Development of Nicotine Loaded Chitosan Nanoparticles for Lung Delivery

Wang¹

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Cigarette smoking has become one of the leading causes of preventable deaths all over the world, causing a serious threat to human wellbeing and a tremendous economic burden to governments. The currently available treatment options for smoking cessation are not efficient. The pulmonary delivery of drugs by methods such as dry powder inhaler (DPI) has been recognized as one of the most efficient routes of drug delivery to the targeted area. The lung delivery of nicotine in this way would be expected to mimic the effects of tobacco smoking and could significantly reduce the negative health effects of smoking that result from nicotine addiction.The aim of this study is to develop nanoparticles with controlled physicochemical properties using biodegradable polymer of chitosan (CS) loaded with nicotine salt for pulmonary delivery as DPI formulations. The outcomes of this project are expected to be a safe and effective CS-based nicotine formulation for pulmonary delivery to treat nicotine dependence. This thesis specially addresses the research questions: (1) how to develop a feasible process to manufacture the nanoparticles suitable for pulmonary drug delivery using biodegradable polymer of CS containing nicotine salt; (2) how to develop an animal model for pulmonary drug delivery from DPI formulation using a nose-only inhalation device.The current therapeutic options for treatment of smoking addiction have been reviewed, and current advancements of technology in pulmonary drug delivery are summarised. Buccal administration of drugs exhibits a low oral bioavailability, and sublingual tablets and chewing gums can be swallowed before being absorbed.Although nasal spray of nicotine is a fast way to deliver nicotine into the bloodstream, Development of Nicotine Loaded Chitosan Nanoparticles for Lung Delivery iii the rate of absorption is still not as rapid as cigarette smoking. Therefore, it is proposed that delivery of nicotine with sustained drug release profile direct into the deep lung is likely to more effectively mimic the rapid effects of cigarette smoking on a physiological level, which could eliminate patient craving and allow the tapering of nicotine level over time to improve patients' compliance.Water in oil (w/o) emulsion crosslinking method has been used to fabricate nicotine hydrogen tartrate (NHT)-loaded CS nanoparticles which separate as solid microaggregates. The physicochemical properties of particles are characterized by a series of techniques. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) shows that the prepared particles are spherical in morphology with rough surface after loading CS particles with NHT. Dynamic Light Scattering (DLS)by Zetasizer determined nanoparticle size ranging from 167.6 nm to 411 nm, while DLS by Mastersizer demonstrated that the microaggregates of these nanoparticles are in the respirable range (<5µm). The surface positive charge as measured by zeta potential tends to decrease with increase of mass ratios of NHT to CS, which is in contr...

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Chitosan nanoparticles loaded with dorzolamide and pramipexole

Cited by 263 publications

References 48 publications

Production and characterization of nanocapsules encapsulated linalool by ionic gelation method using chitosan as wall material

Production and characterization of nanocapsules encapsulated linalool by ionic gelation method using chitosan as wall material

Biocompatibility of folate–modified chitosan nanoparticles

Development of Nicotine Loaded Chitosan Nanoparticles for Lung Delivery

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