Biocompatibility of folate–modified chitosan nanoparticles

Chakraborty, Subhankari Prasad; Sahu, Sumanta Kumar; Pramanik, Panchanan; Roy, Somenath

doi:10.1016/s2221-1691(12)60044-6

Cited by 25 publications

(11 citation statements)

References 10 publications

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“…Normal human lymphocytes and oral squamous epithelial cell, Jurkat and KB cell lines were seeded into 96 wells of tissue culture plates having 180 μl of complete media and were incubated for 48 h. Doxorubicin and PMIDA-coated CoO nanoparticles were added to the cells at different concentrations (1, 5, 10, and 25 μg/ml), were incubated for 48 h at 37 °C in a humidified incubator (NBS) maintained with 5 % CO 2 . The cell viability was estimated by 3-(4,5-dimethylthiazol)-2-diphenyltetrazolium bromide according to the method of our previous laboratory report Chakraborty et al 2011 .…”

Section: Methodsmentioning

confidence: 99%

Surface-modified cobalt oxide nanoparticles: new opportunities for anti-cancer drug development

et al. 2012

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The development of smart nanoparticles that can exhibit the anti-cancer activity, introduces better efficacy and lower toxicity for treatment. The present study was aimed to evaluate the anti-cancer activity of surface functionalized CoO nanoparticles against Jurkat (T-cell lymphoma) and KB (oral carcinoma) cell lines. The nano-sized cobalt oxide nanoparticles (CoO) was prepared by thermal decomposition method followed by surface modification using phosphonomethyl iminodiacetic acid (PMIDA). The PMIDA-coated CoO nanoparticle was characterized by X-ray diffraction, dynamic light scattering, and transmission electron microscopy; and the conjugation was analyzed by Fourier transform infrared spectroscopy. The resultant nanoparticles with an average size less than 100 nm measured by dynamic light scattering and transmission electron microscopy. Cytotoxicity study, flow cytometric analysis and scanning electron micrographs have been revealed that PMIDA-coated nanoparticles significantly enhances the cellular uptake of the nanoparticle and thus facilitates apoptosis of cancer cell (Jurkat and KB). For the application of PMIDA-coated CoO nanoparticles in the medical field, doxorubicin, a potent anti-cancer drug, has been used in similar fashion in this experimental design and all these effects or patterns were observed.

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Section: Methodsmentioning

confidence: 99%

Surface-modified cobalt oxide nanoparticles: new opportunities for anti-cancer drug development

et al. 2012

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“…Differently, they all have potential to overcome the bacterial envelope by disrupting it [12,20] (Figure 5). Therefore, they have been used against Gram-positive and -negative bacterial infections; while carbon nanostructures (CNS) have been mostly used as antimicrobials per se [154][155][156][157], dendrimers and chitosan NPs have been used both alone and as carriers of antibiotics [158][159][160][161][162][163][164].…”

Section: Carbon Nanostructures Dendrimers and Chitosan Nanoparticlesmentioning

confidence: 99%

“…When used in lower concentrations, dendrimers (mostly polyamidoamine (PAMAM) dendrimers), and chitosan NPs, may serve as non-bactericidal reservoirs which can improve antibiotic's half-life, bioavailability and biodistribution [158,159,161,162]. In addition, they may also perturb the bacterial envelope making it somewhat more permeable which eventually improves the delivery of the antibiotic once it has been released from the NPs [160,165].…”

Section: Carbon Nanostructures Dendrimers and Chitosan Nanoparticlesmentioning

confidence: 99%

Nanomaterials and molecular transporters to overcome the bacterial envelope barrier: Towards advanced delivery of antibiotics

Santos

Figueiredo

Azevedo

et al. 2018

Advanced Drug Delivery Reviews

101

100

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With the dramatic consequences of bacterial resistance to antibiotics, nanomaterials and molecular transporters have started to be investigated as alternative antibacterials or anti-infective carrier systems to improve the internalization of bactericidal drugs. However, the capability of nanomaterials/molecular transporters to overcome the bacterial cell envelope is poorly understood. It is critical to consider the sophisticated architecture of bacterial envelopes and reflect how nanomaterials/molecular transporters can interact with these envelopes, being the major aim of this review. The first part of this manuscript overviews the permeability of bacterial envelopes and how it limits the internalization of common antibiotic and novel oligonucleotide drugs. Subsequently we critically discuss the mechanisms that allow nanomaterials/molecular transporters to overcome the bacterial envelopes, focusing on the most promising ones to this end - siderophores, cyclodextrins, metal nanoparticles, antimicrobial/cell-penetrating peptides and fusogenic liposomes. This review may stimulate drug delivery and microbiology scientists in designing effective nanomaterials/molecular transporters against bacterial infections.

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“…Drug-loading content and loading efficiency (LE) of VANP were determined by using the methods of Chakraborty et al 16 and Zhao et al 17 with slight modifications. After 48 hours of shaking, the suspensions of VANP1-7 were centrifuged at 3,500× g for 10 minutes.…”

Section: Determination Of Drug-loading Content and Loading Efficiencymentioning

confidence: 99%

Development of nanoantibiotic delivery system using cockle shell-derived aragonite nanoparticles for treatment of osteomyelitis

Saidykhan¹,

Bakar²,

Rukayadi³

et al. 2016

IJN

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A local antibiotic delivery system (LADS) with biodegradable drug vehicles is recognized as the most effective therapeutic approach for the treatment of osteomyelitis. However, the design of a biodegradable LADS with high therapeutic efficacy is too costly and demanding. In this research, a low-cost, facile method was used to design vancomycin-loaded aragonite nanoparticles (VANPs) with the aim of understanding its potency in developing a nanoantibiotic bone implant for the treatment of osteomyelitis. The aragonite nanoparticles (ANPs) were synthesized from cockle shells by a hydrothermal approach using a zwitterionic surfactant. VANPs were prepared using antibiotic ratios of several nanoparticles, and the formulation (1:4) with the highest drug-loading efficiency (54.05%) was used for physicochemical, in vitro drug release, and biological evaluation. Physiochemical characterization of VANP was performed by using transmission electron microscopy, Fourier transform infrared spectroscopy, X-ray powder diffraction, and Zetasizer. No significant differences were observed between VANP and ANP in terms of size and morphology as both samples were cubic shaped with sizes of approximately 35 nm. The Fourier transform infrared spectroscopy of VANP indicated a weak noncovalent interaction between ANP and vancomycin, while the zeta potential values were slightly increased from −19.4±3.3 to −21.2±5.7 mV after vancomycin loading. VANP displayed 120 hours (5 days) release profile of vancomycin that exhibited high antibacterial effect against methicillin-resistant Staphylococcus aureus ATCC 29213. The cell proliferation assay showed 80% cell viability of human fetal osteoblast cell line 1.19 treated with the highest concentration of VANP (250 µg/mL), indicating good biocompatibility of VANP. In summary, VANP is a potential formulation for the development of an LADS against osteomyelitis with optimal antibacterial efficacy, good bone resorbability, and biocompatibility.

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Biocompatibility of folate–modified chitosan nanoparticles

Cited by 25 publications

References 10 publications

Surface-modified cobalt oxide nanoparticles: new opportunities for anti-cancer drug development

Surface-modified cobalt oxide nanoparticles: new opportunities for anti-cancer drug development

Nanomaterials and molecular transporters to overcome the bacterial envelope barrier: Towards advanced delivery of antibiotics

Development of nanoantibiotic delivery system using cockle shell-derived aragonite nanoparticles for treatment of osteomyelitis

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