Chitosan/nanocellulose electrospun fibers with enhanced antibacterial and antifungal activity for wound dressing applications

Ribeiro, Ana Sofia; Costa, Sofia M.; Ferreira, Diana P.; Calhelha, Ricardo C.; Barros, Lillian; Stojković, Dejan; Sokóvić, Marina; Ferreira, Isabel C.F.R.; Fangueiro, Raúl

doi:10.1016/j.reactfunctpolym.2020.104808

Cited by 59 publications

(17 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The addition of CNC was able to increase the mechanical properties and thermal resistance of the fibers as well as generated a broad‐spectrum antimicrobial effect against gram‐positive and gram‐negative bacteria but was less effective in inhibiting fungi. The addition of acacia extract in combination with CNC leads to the formation of systems with higher antifungal activity and sustained release for up to 24 h. All systems evaluated by the authors did not exhibit cytotoxic activity against nontumor cell lines 146 …”

Section: Nanofiber Application As Wound Dressingsmentioning

confidence: 93%

Advances in the use of electrospinning as a promising technique for obtaining nanofibers to guide epithelial wound healing in diabetics—Mini‐review

Costa

Menezes

Dias

et al. 2022

Polymers for Advanced Techs

View full text Add to dashboard Cite

Diabetes is one of the chronic diseases that most affect the world population, and it is estimated that in a few years it will progressively increase. It can appear at any stage of life, being Type I most common in childhood and Type II in adulthood, but both are related to hyperglycemia. Studies show that physical inactivity, obesity, and poor eating habits can influence the onset and/or worsening of Type II diabetes. Among the complications that diabetics may develop are amputations, these are caused due to the neuropathy that the diabetic develops and ends up losing sensitivity when injured. Consequently, the wounds often become infected ulcers and the tissue dies, leading the patient to undergo surgical procedures for tissue removal. To try to prevent wounds from becoming ulcers and/or to reduce the percentage of amputations, researchers have been using the electro‐spinning technique to form nanofibers. The fibers when electrospun have nanofiber morphology and one of the characteristics of these is the volume/area ratio in which positively increases the properties of the fibers. These are being widely used in tissue engineering as they have been shown to be effective in tissue regeneration. In addition, they prove to be promising in the biomedical area for modified drug release. Polymers such as poly (ε‐caprolactone), poly (lactic‐co‐glycolic acid), gum tragacanth, among others, are gaining ground in the scientific field to produce nanofibers incorporating some antioxidant, antimicrobial, and anti‐inflammatory agent. For treating diabetic wounds, preventing amputation processes and an improvement in the quality of life. The aim of this paper is to review the use of the electrospinning technique to aid the healing of diabetic wounds in the scientific literature.

show abstract

Section: Nanofiber Application As Wound Dressingsmentioning

confidence: 93%

Advances in the use of electrospinning as a promising technique for obtaining nanofibers to guide epithelial wound healing in diabetics—Mini‐review

Costa

Menezes

Dias

et al. 2022

Polymers for Advanced Techs

View full text Add to dashboard Cite

show abstract

“…TGF-beta 1, COL1A1, and COL31A1). Robiero et al developed wound dressings based on chitosan, PEO, cellulose and acacia extract [425]. Using this blend, both antimicrobial and antifungal properties were maintained, showing antimicrobial activity against an array of microorganisms.…”

Section: Electrospinningmentioning

confidence: 99%

“…Reproduced from [427], d) Electrospun PEO/Chitosan membrane containing 1% w/v Chitosan for the enhanced antimicrobial activity for wound dressing applications. Reproduced from [425], e) SEM analysis of PCL methacrylated and gelatin methacryolyl (70:30) fibers used in abdominal hernia repair. Reproduced from [444] f) SEM images showing the fabrication of electrospun aligned fibers composed of PCL, gelatin and multi-walled carbon nanotubes.…”

Section: List Of Tables and Figuresmentioning

confidence: 99%

Recent applications of electrical, centrifugal, and pressurised emerging technologies for fibrous structure engineering in drug delivery, regenerative medicine and theranostics

Mehta

Rasekh

Patel

et al. 2021

Advanced Drug Delivery Reviews

View full text Add to dashboard Cite

“…The developed samples demonstrated antibacterial activity against 6 bacteria species, Gram-positive Bacillus cereus , Listeria monocytogenes and S. aureus , as well as Gram-negative Enterobacter cloacae , E. coli and Salmonella Typhimurium . They also demonstrated antifungal activity against 6 fungi as well as biocompatibility and continuous release of the natural extract during 24 h [ 116 ].…”

Section: Fibrous Structures Functionalized With Nanomaterialsmentioning

confidence: 99%

Protective Multifunctional Fibrous Systems Based on Natural Fibers and Metal Oxide Nanoparticles

2021

Self Cite

View full text Add to dashboard Cite

In recent years, an unprecedented increase in the development of products and technologies to protect the human being has been observed. Now, more than ever, the world population is exposed to several threats, harmful to their well-being and health. Chemical and biological hazardous agents stand out as one of the biggest threats, not only for the military forces, but also for the civilians. Consequently, it’s essential to develop personal protective systems that are able to protect their user, not only passively, but actively, being able to detect, adsorb, degrade and decontaminate pesticides, pollutants, microorganisms and most importantly: chemical/biological warfare agents. One recent strategy for the development of active fibrous structures with improved functions and new properties is their functionalization with nanoparticles (NPs), especially metal oxides. Although their known effectiveness in the decomposition of harmful agents, the NPs could also include other functionalities in the same structure using low quantities of material, without adding extra weight, which is of huge importance for a soldier in the battlefield. The use of natural fibers as the substrate is also very interesting, since this material is a much sustainable alternative when compared to synthetic ones, also providing excellent properties.

show abstract

Chitosan/nanocellulose electrospun fibers with enhanced antibacterial and antifungal activity for wound dressing applications

Cited by 59 publications

References 45 publications

Advances in the use of electrospinning as a promising technique for obtaining nanofibers to guide epithelial wound healing in diabetics—Mini‐review

Advances in the use of electrospinning as a promising technique for obtaining nanofibers to guide epithelial wound healing in diabetics—Mini‐review

Recent applications of electrical, centrifugal, and pressurised emerging technologies for fibrous structure engineering in drug delivery, regenerative medicine and theranostics

Protective Multifunctional Fibrous Systems Based on Natural Fibers and Metal Oxide Nanoparticles

Contact Info

Product

Resources

About