Chitosan/NaF Particles Prepared Via Ionotropic Gelation: Evaluation of Particles Size and Morphology

Furtado, Glória Tamiris Farias da Silva.; Fideles, Thiago Bizerra; Cruz, Rita de Cássia Alves Leal; Souza, José William de Lima; Rodríguez, Miguel Á.; Fook, Marcus Vinícius Lia

doi:10.1590/1980-5373-mr-2018-0101

Cited by 19 publications

(20 citation statements)

References 26 publications

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“…The peak at 1719 cm −1 was attributed to C=O stretching vibration, while the peak at 1120 cm −1 to asymmetric stretching vibration of C-O-C bridge [ 31 ]. The characteristic peaks of TPP at 1212, 1136 and 884 cm −1 corresponded to P=O stretching vibration, asymmetric and symmetric vibration in O-P=O groups and asymmetric stretching vibration of P-O-P bridge, respectively [ 32 ].…”

Section: Resultsmentioning

confidence: 99%

Gradient Chitosan Hydrogels Modified with Graphene Derivatives and Hydroxyapatite: Physiochemical Properties and Initial Cytocompatibility Evaluation

Kosowska

Domalik-Pyzik

Sekuła-Stryjewska

et al. 2020

IJMS

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In this study, we investigated preparation of gradient chitosan-matrix hydrogels through a novel freezing–gelling–thawing method. The influence of three types of graphene family materials (GFM), i.e., graphene oxide (GO), reduced graphene oxide (rGO), and poly(ethylene glycol) grafted graphene oxide (GO-PEG), as well as hydroxyapatite (HAp) on the physicochemical and biological properties of the composite hydrogels was examined in view of their potential applicability as tissue engineering scaffolds. The substrates and the hydrogel samples were thoroughly characterized by X-ray photoelectron spectroscopy, X-ray diffractometry, infrared spectroscopy, digital and scanning electron microscopy, rheological and mechanical analysis, in vitro chemical stability and bioactivity assays, as well as initial cytocompatibility evaluation with human umbilical cord Wharton’s jelly mesenchymal stem cells (hUC-MSCs). We followed the green-chemistry approach and avoided toxic cross-linking agents, using instead specific interactions of our polymer matrix with tannic acid, non-toxic physical cross-linker, and graphene derivatives. It was shown that the most promising are the gradient hydrogels modified with GO-PEG and HAp.

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Section: Resultsmentioning

confidence: 99%

Gradient Chitosan Hydrogels Modified with Graphene Derivatives and Hydroxyapatite: Physiochemical Properties and Initial Cytocompatibility Evaluation

Kosowska

Domalik-Pyzik

Sekuła-Stryjewska

et al. 2020

IJMS

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“…e signals in the region of 3700-2800 cm −1 in the CH spectra (Figures 2(a), and 2(b) (1)) correspond to the stretching vibrations of the O-H, N-H, and C-H bonds [9,32]. e bands located at 1648 cm −1 and 1557 cm −1 arise from the symmetric stretching vibrations of the carbonyl and amino groups, respectively [9,33]. ), blank and with extract, shift to 1636 cm −1 and 1542 cm −1 , respectively.…”

Section: Structural Characterization Of the Particles By Ftirmentioning

confidence: 97%

Synthesis and Characterization of Chitosan Particles Loaded with Antioxidants Extracted from Chia (Salvia hispanica L.) Seeds

Morales-Olán

Luna-Suárez

Figueroa‐Cárdenas

et al. 2021

International Journal of Analytical Chemistry

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Chia (Salvia hispanica L.) seeds contain antioxidants with great benefits for health and are widely used in the food industry. Antioxidants can be degraded by environmental factors, decreasing their biological activity. Their encapsulation in chitosan (CH) particles represents an alternative to protect them and increases their application. The encapsulation efficiency (%EE) of the antioxidants in the CH particles depends on the synthesis conditions. In this study, two methods for encapsulation of chia extract in chitosan particles were evaluated: method A, 0.05% CH in 1% acetic acid was mixed with 0.07% of tripolyphosphate (TPP) and method B, 0.3% CH in 2% acetic acid was mixed with 1% TPP. The results showed that the %EE decreased with the concentration of the extract, and the FTIR analysis suggested that the compounds of the extract were adsorbed on the surface of the particles. Dynamic light scattering and zeta potential analysis showed that the particles of method A are unstable and with a tendency to agglomerate, and the particles of method B are stable. The highest %EE was obtained with 0.2 mg·mL−1 (method A) and 1.0 mg·mL−1 (method B) of the extract. The higher loading capacity (%LC) (16–72%) was exhibited by the particles of method A. The best particle yield (62–69%) was observed for method B. The particles with the extract adsorbed showed antioxidant activity (5–60%) at 25°C; however, in the particles with the extract encapsulated, the activity increased after subjecting to acidic conditions at 40°C due to the breakdown of the particles. The results obtained will allow choosing the appropriate conditions for the synthesis of chitosan particles loaded with chia extracts with specific characteristics (%EE, %LC, size, and type) according to their future applications. The particles could be used in food and pharmaceutical industries and even in edible films for food packaging.

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“…In 2018, Furtado et al reported the synthesis of chitosan and sodium fluoride (Ch-NaF) nanoparticles using this method [ 72 ]. This method is generally considered safe since it removes the dangers and toxicity that are associated with the use of organic solvents; it is also considered simple and easy with the use of an aqueous medium [ 62 ].…”

Section: Chitosan Nanoparticlesmentioning

confidence: 99%

Functionalized Chitosan Nanomaterials: A Jammer for Quorum Sensing

et al. 2021

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The biggest challenge in the present-day healthcare scenario is the rapid emergence and spread of antimicrobial resistance due to the rampant use of antibiotics in daily therapeutics. Such drug resistance is associated with the enhancement of microbial virulence and the acquisition of the ability to evade the host’s immune response under the shelter of a biofilm. Quorum sensing (QS) is the mechanism by which the microbial colonies in a biofilm modulate and intercept communication without direct interaction. Hence, the eradication of biofilms through hindering this communication will lead to the successful management of drug resistance and may be a novel target for antimicrobial chemotherapy. Chitosan shows microbicidal activities by acting electrostatically with its positively charged amino groups, which interact with anionic moieties on microbial species, causing enhanced membrane permeability and eventual cell death. Therefore, nanoparticles (NPs) prepared with chitosan possess a positive surface charge and mucoadhesive properties that can adhere to microbial mucus membranes and release their drug load in a constant release manner. As the success in therapeutics depends on the targeted delivery of drugs, chitosan nanomaterial, which displays low toxicity, can be safely used for eradicating a biofilm through attenuating the quorum sensing (QS). Since the anti-biofilm potential of chitosan and its nano-derivatives are reported for various microorganisms, these can be used as attractive tools for combating chronic infections and for the preparation of functionalized nanomaterials for different medical devices, such as orthodontic appliances. This mini-review focuses on the mechanism of the downregulation of quorum sensing using functionalized chitosan nanomaterials and the future prospects of its applications.

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Chitosan/NaF Particles Prepared Via Ionotropic Gelation: Evaluation of Particles Size and Morphology

Cited by 19 publications

References 26 publications

Gradient Chitosan Hydrogels Modified with Graphene Derivatives and Hydroxyapatite: Physiochemical Properties and Initial Cytocompatibility Evaluation

Gradient Chitosan Hydrogels Modified with Graphene Derivatives and Hydroxyapatite: Physiochemical Properties and Initial Cytocompatibility Evaluation

Synthesis and Characterization of Chitosan Particles Loaded with Antioxidants Extracted from Chia (Salvia hispanica L.) Seeds

Functionalized Chitosan Nanomaterials: A Jammer for Quorum Sensing

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