Chitosan-modified hyaluronic acid-based nanosized drug carriers

Turcsányi, Árpád; Varga, Norbert; Csapó, Edit

doi:10.1016/j.ijbiomac.2020.01.118

Cited by 31 publications

(22 citation statements)

References 30 publications

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“…TCP treated Chit-HA gave shape stability and encapsulation as a nanoparticle carrier. Chit+TCP+HA shell was used in the 3rd group which showed the best results with encapsulation, shape stability, homogeneity and drug carriage for both vitamin D3 and vitamin E. The results of the study proved that HA can be used as a nanodrug delivery system along with Chitosan and TCP as it provides a proper encapsulation and a sustainable drug release system (34).…”

Section: Nanosystem For Drug Deliverymentioning

confidence: 92%

Potential for Hyaluronic Acid in Periodontal Research

Singh¹,

Roy²

2021

Preprint

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Hyaluronic acid, known also as hyaluronan, is the most abundant glycosaminoglycan in the extracellular matrix. It is produced by most of the cells in the human body, possibly contributing to various fundamental biological processes. This prompts interest in its therapeutic value. Hyaluronic acid (HA) has been used for various treatments owing to its broad range of properties in medical and dental field specially in periodontology. The review gives an overview on the effects of HA on fibroblasts, bone, wound healing, periodontal regeneration, aphthous ulcer/stomatitis and stem cells. Outcomes of including Hyaluronic acid in non-surgical periodontal therapy, drug delivery system and surgical procedures such as root coverage, papilla regeneration, root conditioning, intrabony defects, guided tissue regeneration are rather optimistic. HA has shown astounding potential in treating periimplantitis. Newer frontiers have to be explored to comprehend the other promising properties of HA. Keyword – Hyaluronic Acid, Periodontology.

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Section: Nanosystem For Drug Deliverymentioning

confidence: 92%

Potential for Hyaluronic Acid in Periodontal Research

Singh¹,

Roy²

2021

Preprint

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“…For instance, several polysaccharides such as chitosan, chondroitin sulfate, alginate, hyaluronic acid (HA) have been used to improve the active targeting of nanoparticle drug delivery systems [ 30 , 97 , 98 , 99 ]. Concerning HA, many studies have shown that HA-based nanoparticles can serve to efficiently target the CD44 glycoprotein, whose isoforms and their altered glycosylation are correlated with metastatic properties of human cancer [ 100 , 101 , 102 ]. Lastly, interesting models have been proposed and applied to various glycosylation targets, especially in combination with nanoparticle carrier systems.…”

Section: Decorating Nanoparticles Surfaces With Tacas-binding Molementioning

confidence: 99%

Targeting the “Sweet Side” of Tumor with Glycan-Binding Molecules Conjugated-Nanoparticles: Implications in Cancer Therapy and Diagnosis

et al. 2021

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Nanotechnology is in the spotlight of therapeutic innovation, with numerous advantages for tumor visualization and eradication. The end goal of the therapeutic use of nanoparticles, however, remains distant due to the limitations of nanoparticles to target cancer tissue. The functionalization of nanosystem surfaces with biological ligands is a major strategy for directing the actions of nanomaterials specifically to tumor cells. Cancer formation and metastasis are accompanied by profound alterations in protein glycosylation. Hence, the detection and targeting of aberrant glycans are of great value in cancer diagnosis and therapy. In this review, we provide a brief update on recent progress targeting aberrant glycosylation by functionalizing nanoparticles with glycan-binding molecules (with a special focus on lectins and anti-glycan antibodies) to improve the efficacy of nanoparticles in cancer targeting, diagnosis, and therapy and outline the challenges and limitations in implementing this approach. We envision that the combination of nanotechnological strategies and cancer-associated glycan targeting could remodel the field of cancer diagnosis and therapy, including immunotherapy.

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“…The preparation of the Chit-HyA drug carriers was reproduced from our previous work, with slight changes [10]. The TPP cross-linked Chit-HyA NPs (labeled as type II) were fabricated using the ionic gelation method.…”

Section: Preparation Of Polysaccharide-based Colloidal Drug Carrier Particlesmentioning

confidence: 99%

“…Accordingly, they are used in several forms (hydrogels, films, and nanoparticles (NPs)) and applications [2,[6][7][8]. The precise combination of these oppositely charged polysaccharides can produce finely tuned NPs, which can be used for gene delivery, or for loading different drugs and cancer therapeutics [9,10].…”

Section: Introductionmentioning

confidence: 99%

“…The main motivation of this work was to investigate the limitations of the applicability of protein-stabilized red-emitting Au NCs as effective FRs for labeling of polysaccharide-based colloidal drug delivery systems. Namely, bovine serum albumin-(BSA-Au NCs) and lysozyme-directed (LYZ-Au NCs) Au NCs as fluorescent markers and chitosan-modified hyaluronic acid based colloidal nanoparticles as drug carriers with tocopherol as a test drug were fabricated reproductively according to our previous works [10,29]. On one hand, the quantitative evaluation of the Au NC-polymer carrier interaction was accomplished and the formation, the size distribution and stability of the fluorescent metal cluster/polymer carrier complexes were also investigated at several cluster:carrier mass ratios.…”

Section: Introductionmentioning

confidence: 99%

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Fluorescent Labeling of Hyaluronic Acid-Chitosan Nanocarriers by Protein-Stabilized Gold Nanoclusters

2020

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In medical research the visualization of drug carrier accumulation and release of the loaded drugs in vivo is an important field. In this work, two protein-stabilized gold nanoclusters (Au NCs) as effective fluorescent reporters (FRs) were investigated for labeling of biocompatible chitosan-modified hyaluronic acid based nanocarriers having two different structures. The colloid stability of the labeled carriers was studied by dynamic light scattering and Zeta potential measurements, while the changes in the fluorescence of the lysozyme- (LYZ) and bovine serum albumin (BSA)-stabilized Au NCs were analyzed by spectrofluorimetry and confocal fluorescent microscopy. We found that the labeling was effective with a wide range of marker:carrier mass ratios, and the fluorescence of the NCs and the colloid stability of the complexes were retained. Labeling during preparation and subsequent labeling were compared, and based on composition (nanocluster:carrier mass ratio) and structure of the complex systems we preferred the latter method, as it left the Au NCs free for further modifications. Considering both marker:carrier mass ratios and emission intensities, the LYZ-stabilized Au NCs proved to be better labels. The core-shell type carrier formulations showed increased fluorescence with LYZ-stabilized NCs, presumably from aggregation induced emission.

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Chitosan-modified hyaluronic acid-based nanosized drug carriers

Cited by 31 publications

References 30 publications

Potential for Hyaluronic Acid in Periodontal Research

Potential for Hyaluronic Acid in Periodontal Research

Targeting the “Sweet Side” of Tumor with Glycan-Binding Molecules Conjugated-Nanoparticles: Implications in Cancer Therapy and Diagnosis

Fluorescent Labeling of Hyaluronic Acid-Chitosan Nanocarriers by Protein-Stabilized Gold Nanoclusters

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