Chitosan-Modified Cationic Amino Acid Nanoparticles as a Novel Oral Delivery System for Insulin

Abbad, Sarra; Zhang, Zhenhai; Waddad, Ayman Y.; Munyendo, Were L. L.; Lv, Huixia; Zhou, Jianping

doi:10.1166/jbn.2015.1924

Cited by 40 publications

(21 citation statements)

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“…The critical micelle concentration (CMC) of SMs and MMs was determined by uorescence spectroscopy (F-2500, Hitachi Co., Japan) similar to the previous report. 23…”

Section: Preparation Of Micellesmentioning

confidence: 99%

Paclitaxel prodrug based mixed micelles for tumor-targeted chemotherapy

et al. 2018

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“…The critical micelle concentration (CMC) of SMs and MMs was determined by uorescence spectroscopy (F-2500, Hitachi Co., Japan) similar to the previous report. 23…”

Section: Preparation Of Micellesmentioning

confidence: 99%

Paclitaxel prodrug based mixed micelles for tumor-targeted chemotherapy

et al. 2018

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“…As part of the gut associated lymphoid tissue (GALT), Peyer's patches have an important role in eliciting immune responses against oral antigens, as reviewed elsewhere . However, since absorption studies do not use models that include enterocytes, goblet, and M cells simultaneously, the insulin absorption pathway is still unknown (Abbad et al, 2015). Furthermore, these studies showed NP uptake by epithelial cells, but did not prove their transport across those cells.…”

Section: Undesired Adjuvanticity Of Chit: Potential Immunotoxicity Ofmentioning

confidence: 99%

“…There are many different protocols for insulin encapsulation into Chit NPs (Figure 2). Insulin can be pre-dissolved in diluted hydrogen chloride (HCl) solution (Abbad et al, 2015), the pH of this final solution can be adjusted with sodium hydroxide FIGURE 2 | Differences on Chit-ins NPs production protocols.…”

Section: Drug Encapsulation Intomentioning

confidence: 99%

“…Due to the pH variation, these NPs become less stable and disintegrate releasing the insulin, which is absorbed through the paracellular pathway into the systemic circulation (Borchard et al, 1996;Sung et al, 2012). In reality, other transport pathways can be involved after oral administration of Chit-Ins NPs (Abbad et al, 2015), such as transcytosis through enterocytes, receptor-mediated transcytosis, and transcellular absorption by M cells in the Peyer's patches. As part of the gut associated lymphoid tissue (GALT), Peyer's patches have an important role in eliciting immune responses against oral antigens, as reviewed elsewhere .…”

Section: Undesired Adjuvanticity Of Chit: Potential Immunotoxicity Ofmentioning

confidence: 99%

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How the Lack of Chitosan Characterization Precludes Implementation of the Safe-by-Design Concept

Marques

Som

Schmutz

et al. 2020

Front. Bioeng. Biotechnol.

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Efficacy and safety of nanomedicines based on polymeric (bio)materials will benefit from a rational implementation of a Safe-by-Design (SbD) approach throughout their development. In order to achieve this goal, however, a standardization of preparation and characterization methods and their accurate reporting is needed. Focusing on the example of chitosan, a biopolymer derived from chitin and frequently used in drug and vaccine delivery vector preparation, this review discusses the challenges still to be met and overcome prior to a successful implementation of the SbD approach to the preparation of chitosan-based protein drug delivery systems.

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“…It is difficult to further increase L-Phe graft ratio above 20.2%, probably due to the simultaneous grafting and intramolecular reaction of L-Phe. 26 Figure S2A shows the 1 H-NMR spectra of the starting materials (CS 150 kDa), L-Phe and CS-g-N-Phe copolymers. Compared to nonmodified CS ( Fig.…”

Section: Synthesis and Characterization Of Cs-g-n-phe Copolymersmentioning

confidence: 99%