Chitosan microspheres with hydrocortisone and hydrocortisone–hydroxypropyl-β-cyclodextrin inclusion complex

Optimization of prednisolone acetate-loaded chitosan microspheres using a 23factorial design for preventing restenosis

“…Desai and Park (2005) used a dialysis technique while Ganza-Gonzales et al (1999) and Gavini et al (2006) used the USP basket method. The in vitro release technique used in our study was used by Filipovic-Grcic et al (2000) and the results obtained from our in vitro release study were concordant with those studies. The optimum microsphere formulation (CM1PA20) showed the best encapsulation efficiency (45.7 ± 0.3%) and it released the total amount incorporated in the microspheres.…”

“…The spray-drying process and dispersion of drug into the polymer matrix led to the amorphization of PA and due to this process the endothermic melting peak disappeared (Filipovic-Grcic et al, 2000;Takahashi et al, 2005). From the results obtained, it could be concluded that the drug dispersed into the microspheres.…”

FORMULATION AND CHARACTERIZATION OF INCLUSION COMPLEXES USING HYDROXYPROPYL-β-CYCLODEXTRIN AND FLORFENICOL WITH CHITOSAN MICROPARTICLES

“…Furthermore, in the Q-FF, as well as, Q-SDFF MPs the FF was released in a sustained manner compared with CdI. According to Filipovic-Grcic et al 4 this difference could be attributed to the difference in the degree of swelling and subsequent uptake of water that could result in a local solubilisation action of the MPs. On the other hand, Cerchiara et al 6 attributed that the retardant effect of chitosan can be explained by the slow diffusion of the drug through the more hydrophilic chitosan/cyclodextrin matrix layer around the lypophilic drug.…”

“…In the context of drug delivery, it has been used to prepare microparticles and nanoparticles together with CD [4][5][6][7] .…”

Coencapsulation of trans-Dehydrocrotonin and trans-Dehydrocrotonin:hydroxypropyl-β-cyclodextrin into Microparticles

“…11 Inclusion complexes of drugs with cyclodextrins (CDs) have been entrapped into microparticles in order to optimize the properties of solubility, stability, release and therapeutic of the biocompounds. 12,13 Based on a novel approach aiming at controlled profile for release of hypnotic agent zolpidem (ZP) with simultaneous use of hydroxypropyl-β-cyclodextrin (HP-β-CD) added to the aqueous phase and ZP to the organic phase on PLGA and poly(DL-lactide) (PDLLA) microparticles, it was possible to evaluate the coencapsulated effect of free drug ZP and HP-β-CD. 14 Generally the coencapsulation strategy refers to simultaneous encapsulation of different molecules such as drugs, markers, chemical entities, polymers.…”