Chitosan microspheres as a potential carrier for drugs

Sinha, Vivek Ranjan; Singla, Anil Kumar; Wadhawan, Shweta; Kaushik, R.D.; Kumria, Rachna; Bansal, Kavita; Dhawan, Sanju

doi:10.1016/j.ijpharm.2003.12.026

Cited by 921 publications

(608 citation statements)

References 168 publications

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“…Pada penelitian ini menggunakan jenis penyalut kitosan dan alginat. Kitosan merupakan biopoliaminsakarida, bersifat biokompatibel, biodegradabel dan tidak beracun sehingga aman untuk dikonsumsi (Sinha et al, 2004). Peranan kitosan mulai banyak dikembangkan dalam berbagai industri seperti industri makanan, industri kosmetik dan industri farmasi.…”

Section: Pendahuluanunclassified

The Influence of Coating Material Difference Against Encapsulation Efficiency of Red Ginger Oleoresin

et al. 2017

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ABSTRAKTujuan penelitian ini adalah untuk mengetahui pengaruh perbedaan bahan penyalut terhadap efisiensi enkapsulasi oleoresin jahe merah dan karakterisasi permukaan mikrokapsul. Proses enkapsulasi diawali dengan melarutkan kitosan dalam asam asetat 1 % dan melarutkan sodium alginate menggunakan akuades yang akan digunakan sebagai bahan penyalut. Oleoresin jahe merah dimasukan dalam larutan alginate kemudian diaduk, selanjutntnya campuran dimasukan ke dalam larutan kitosan dan ditambahkan tween 80 dan diaduk menggunakan homogenizer untuk membuat emulsi. Emulsi yang terbentuk dimasukan dalam spray dryer untuk dikonversi menjadi bubuk mikrokapsul kemudian analisis efisiensi enkapsulasi dan morfologi permukaan mikrokapsul menggunakan scanning electron microscopy (SEM). Perbedaan bahan penyalut yang digunakan yaitu kitosan, campuran kitosan-alginat dan campuran kitosan-alginat-sodium tripolifosfat (STPP). Rasio berat oleoresin dengan bahan penyalut adalah 1:1, 1:2 dan 1:3. Efisiensi enkapsulasi tertinggi diperoleh pada bahan penyalut campuran kitosan-alginat-sodium tripolifosfat (STPP) dengan rasio 1 : 3 yaitu sebesar 85,714 %.Kata kunci: efisiensi enkapsulasi, kitosan, oleoresin jahe merah, sodium alginat. ABSTRACTThe purpose of this study was to determine the effect of coating materials on the efficiency of red ginger oleoresin encapsulation and characterization of microcapsule surface. The encapsulation process was started by dissolving chitosan with 1 % (v/v) acetic acid and dissolving sodium alginate using aquadest as a coating material. Red ginger oleoresin was mixed with alginate and then homogenously stirred with chitosan solution and Tween 80 to make an emulsion. The emulsion was converted to a powder of microcapsules using spray dryer. The encapsulation efficiency and surface morphology of microcapsules was analyzed using scanning electron microscopy (SEM). The coating

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Section: Pendahuluanunclassified

The Influence of Coating Material Difference Against Encapsulation Efficiency of Red Ginger Oleoresin

et al. 2017

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“…10 Chitosans can exist in many structural conformations, depending on a variety of factors that include the degree of hydration, the counterion mixture, and the complexity of the original chitin mixture. 11 Chitin-and chitosan-based products have been advanced for a wide variety of applications, including wound healing, 12 pharmaceutical formulation, [12][13][14][15][16] tissue engineering, [17][18][19][20][21] and surface hemostasis. 22,23 However, medical product development with these materials has been hampered by the chemical and physical heterogeneity of the polymer products and contamination of preparations by proteins and other components.…”

Section: Introductionmentioning

confidence: 99%

Hemostatic properties of glucosamine‐based materials

Fischer

Bode

Demcheva

et al. 2006

J Biomedical Materials Res

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Glucosamine-and N-acetyl glucosamine-containing polymers are being used in an increasing number of biomedical applications, including in products for surface (topical) hemostasis. The studies presented here investigate the relationship between the structure (conformation) and function (activation of hemostasis) of glucosamine-based materials. Several polymer systems were studied, including fibers isolated from a microalgal source containing poly-N-acetyl glucosamine polymers that are organized in a parallel, hydrogen-bonded tertiary structure and can be chemically modified to an antiparallel orientation; and gel formulation derivatives of the microalgal fibers consisting of partially deacetylated (F2 gel) and fully deacetylated (F3 gel) polymers. Comparison of the properties of the poly-N-acetyl glucosamine fiber-derived materials with chitin, chitosan, and commercial chitosan-based products are presented. Several studies were performed with the glucosamine-based materials, including (1) an analysis of the ability of materials to activate platelets and turnover of the intrinsic coagulation cascade, (2) an examination of the viscoelastic properties of mixtures of platelet-rich plasma and the glucosamine-based materials via thromboelastography, and (3) scanning electron microscopic studies to examine the morphology of the glucosamine-based materials. The results presented demonstrate that hemostatic responses to the glucosamine-based materials studied are highly dependent on their chemical nature and tertiary/quaternary structure. The unique natural microalgal fibers were found to have strongly prohemostatic activity compared to the other materials studied.

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“…71 A tecnologia de sistemas poliméricos de liberação controlada de fármacos tem sido estudada em detalhes nos últimos 30 anos com relevantes artigos de revisão. 62,63,68 O interesse neste campo tem aumentado consideravelmente, especialmente após o sucesso comercial de produtos, tais como Lupron Depot  , Zoladex  , Norplant  e Gliadel  que usam os princípios de liberação localizada e sustentada.…”

Section: Sistemas De Liberação De Fármacos a Partir De Matrizes De Quunclassified

“…Dentre os biomateriais citados, a quitosana é muito discutida em relação às aplicações biomédicas e de alimentos. 3,4,6,[57][58][59][60][61][62][63][64][65][66][67][68] Atualmente, a quitosana é produzida em grande escala em vários países e, devido à facilidade de se obter o polímero em várias formas 69 A descoberta da quitosana data do século XIX. No entanto, somente nas últimas duas décadas a importância deste polímero tem crescido significativamente em função de ser uma fonte renovável e biodegradável e, também, por causa do recente aumento no conhecimento da sua funcionalidade nas aplicações tecnológicas e biomédicas.…”

Section: Introductionunclassified

Quitosana: biopolímero funcional com potencial industrial biomédico

Laranjeira¹,

Fávere²

2009

Quím. Nova

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Recebido em 27/1/09; aceito em 13/3/09; publicado na web em 2/4/09 CHITOSAN: FUNCTIONAL BYOPOLYMER WITH BIOMEDICAL INDUSTRIAL POTENTIAL. The importance of chitosan has grown significantly over the last two decades due to its renewable and biodegradable source, and also because of the recent increase in the knowledge of its functionality in the technological and biomedical applications. The present article reviews the biopolymer chitosan and its derivatives as versatile biomaterials for potential drug delivery systems, as well as tissue engineering applications, analgesia and treatment of arthritis.

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Chitosan microspheres as a potential carrier for drugs

Cited by 921 publications

References 168 publications

The Influence of Coating Material Difference Against Encapsulation Efficiency of Red Ginger Oleoresin

The Influence of Coating Material Difference Against Encapsulation Efficiency of Red Ginger Oleoresin

Hemostatic properties of glucosamine‐based materials

Quitosana: biopolímero funcional com potencial industrial biomédico

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