Chitosan Hydrogel in combination with Nerolidol for healing wounds

Ferreira, Maria Onaira Gonçalves; Leite, Layara Lorrana Ribeiro; Lima, Idglan S. de; Barreto, Humberto Medeiros; Nunes, Lívio César Cunha; Ribeiro, Alessandra Braga; Osajima, Josy A.; Filho, Edson Cavalcanti da Silva

doi:10.1016/j.carbpol.2016.07.037

Cited by 66 publications

(23 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The infrared spectrum of pure chitosan gel lyophilized (CG), Figure 2a, has some characteristic bands such as the intense band from the N-H axial deformation and the OH stretch vibration of the hydroxyl structure in the region of 3550-3100 cm −1 , which has enlargement caused by numerous interactions proving gel formation. Approximately at 1650 cm −1 appears the band from the C=O of amide axial deformation, at 1551 cm −1 appears the amine groups deformation and at 1465-1423 cm −1 there is the OH and CH 2 deformation [4]. In the region between 1200-900 cm −1 there is the presence of a broad band referring to the polysaccharide structure of chitosan [19].…”

Section: Thermal Analysismentioning

confidence: 99%

“…Chitosan is a biopolymer that has been widely studied to be used in several areas, as it has biocompatibility, biodegradability, non-toxicity, mucoadhesion, and antimicrobial activity [1]. It has been used in tissue engineering [2], dressings, accelerating healing [3,4], wound care [5], and other biomedical and pharmaceutical applications [6].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Biocompatible Gels of Chitosan–Buriti Oil for Potential Wound Healing Applications

et al. 2020

Self Cite

View full text Add to dashboard Cite

The buriti oil (Mauritia flexuosa L.) can be associated with polymeric matrices for biomedical applications. This study aimed to evaluate the effect of chitosan gel (CG) associated with buriti oil (CGB) as a healing agent. The fatty acids and volatile compounds composition of buriti oil were performed and the composite gels were characterized using FTIR and thermal analysis. Biological tests including antimicrobial, antioxidant, anti-inflammatory and healing effects were also investigated. Buriti oil is composed of oleic and palmitic acids, and the main volatile compounds were identified. The buriti oil did not show antimicrobial activity, on the other hand, the composite gel (chitosan and oil) proved to be efficient against Staphylococcus aureus and Klebsiella pneumonia at the 10 mg/mL. Similar behavior was observed for antioxidant activity, determined by the β-carotene bleaching assay, composite gels presenting higher activity and buriti oil showed anti-inflammatory activity, which may be related to the inhibition of the release of free radicals. Regarding wound healing performed using in vivo testing, the composite gel (CGB) was found to promote faster and complete wound retraction. The results indicated that the gel chitosan–buriti oil has a set of properties that improve its antibacterial, antioxidant and healing action, suggesting that this material can be used to treat skin lesions.

show abstract

Section: Thermal Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Biocompatible Gels of Chitosan–Buriti Oil for Potential Wound Healing Applications

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…The procedures were approved by the Ethical Committee of Medical Faculty Universitas Padjadjaran, with ethical approval number 1036/UN6.KEP/EC/2018. The anesthesia (2.5 mg/kg BW of Valisanbe intramuscularly) was injected before the evaluation to minimize pain in the animal tests [ 58 ].…”

Section: Methodsmentioning

confidence: 99%

“…In vivo healing activity was performed in Swiss–Webster strain mice ( Mus musculus ) that were 2–3 months old and weighed 20–30 g. The number of mice used was 20, divided into four groups, with 5 mice in each group. The animals were placed at a constant temperature (26 ± 1 °C) before the evaluation [ 58 ]. The hair of the mice was shaved, then their back skin was swabbed with 70% alcohol, and two full-thickness wounds were created on the back of each mouse using a sterile biopsy punch (8 mm in diameter) [ 40 ].…”

Section: Methodsmentioning

confidence: 99%

Enhancement of α-Mangostin Wound Healing Ability by Complexation with 2-Hydroxypropyl-β-Cyclodextrin in Hydrogel Formulation

et al. 2020

View full text Add to dashboard Cite

α-Mangostin (α-M), one of the active compounds in Garcinia mangostana peel, has been effectively used in wound healing. However, its poor solubility in aqueous solution causes low bioavailability for skin ulcers, hindering its application in wound healing. The aim of this study was to improve the solubility of α-M through complex formation with 2-hydroxypropyl-β-cyclodextrin (α-M/HP-β-CD CX) and to evaluate the healing activity of the complex. The α-M/HP-β-CD CX was incorporated in a sodium carboxymethylcellulose hydrogel (α-M/HP-β-CD CX HG), and the in vivo healing activity was examined in mice. Evaluation of α-M/HP-β-CD CX HG, including organoleptic evaluation, homogeneity, pH, spreadability, swelling ratio, consistency, scanning electron microscopy (SEM), and in vitro drug release, was carried out. The complex formation of α-M/HP-β-CD CX was confirmed by FTIR and PXRD analysis. The solubility of the α-M/HP-β-CD CX in water linearly increased about 11.7-fold compared to α-M alone, and by 3.5-fold compared to the α-M/HP-β-CD physical mixture (α-M/HP-β-CD CX PM). The α-M/HP-β-CD CX HG was homogenous, the pH was found to be in the neutral range, the spread area was 5 cm, and the consistency was stable until 14 days. SEM analysis showed that α-M/HP-β-CD CX HG surged due to the porous structure of the HG. In addition, in vitro release of α-M from α-M/HP-β-CD CX HG was considerably increased compared to α-M/HP-β-CD PM HG and α-M HG. Notably, in vivo evaluation in mice showed that α-M/HP-β-CD CX HG significantly accelerated the wound healing ability compared to other HGs. Thus, α-M/HP-β-CD CX HG has potential as a new formulation of α-M for wound healing therapy.

show abstract

“…In conclusion, it was identified that chitosan hydrogels, with or without silver nanoparticles, have sustained bactericidal activity against S. mutans. 36 A chitosan hydrogel with 1% silver sulfadiazine was studied and rheological, biological and therapeutic characterizations of this hydrogel were made. The authors identified that the chitosan hydrogel presented pseudopasticity and bioadhesiveness that benefited the neovascularization and the inflammatory action in burns, as well, this gel showed adequate and coherent rheological properties for the mechanism of drug release.…”

Section: Regardingmentioning

confidence: 99%

Chitosan, zinc oxide and pink pepper essential oil: potential properties and applications

Garcia¹,

Andrade

Silva³

et al. 2018

Rev enferm UFPE on line.

View full text Add to dashboard Cite

RESUMOObjetivo: descrever propriedades e aplicações potenciais da quitosana, óxido de zinco e óleo essencial de pimenta rosa. Método: estudo descritivo, tipo informativo, mediante o levantamento do universo da produção científica. Resultados: a quitosana é um polímero que possui características tais como biodegrabilidade, biocompatibilidade, atoxicidade, baixo custo, produto natural e existe em grande quantidade na natureza. É suscetível de ser manipulada nos formatos de lâminas, filmes, fibras e géis. É uma molécula extremamente funcional exercendo ação mucoadesiva, anticoagulante, imunoestimulante, cicatrizante, antitumoral, hemostática, hipolipêmica, antimicrobiana, dentre outras. O óxido de zinco é um antimicrobiano com extraordinária eficácia bactericida e fungicida. Estudos têm investigado o óleo essencial da pimenta rosa e identificado que ele possui atividade diurética, adstringente, antidiarreica, anti-inflamatória, cicatrizante, bactericida, antiviral, analgésica, sedativa, expectorante, antipirética, vermífuga e antisséptica. Conclusão: a quitosana, o óxido de zinco e o óleo essencial de pimenta rosa apresentam, individualmente ou em conjunto, potencialidades para aplicações em áreas tais como embalagens ativas, tratamento de água, curativos e outras, em consequência da competência para minimizar ou erradicar a proliferação de micro-organismos patógenos. Descritores: Anacardiaceae; Hidrogel; Óxido de Zinco; Polímeros; Produtos Biológicos; Quitosana.ABSTRACT Objective: to describe properties and potential applications of chitosan, zinc oxide and pink pepper essential oil. Method: a descriptive study, of informative type, by surveying the universe of scientific production. Results: chitosan is a polymer that has characteristics such as biodegradability, biocompatibility, toxicity, low cost, natural product and exists in great quantity in nature. It is susceptible of being manipulated in the formats of slides, films, fibers and gels. It is an extremely functional molecule exerting mucoadhesive, anticoagulant, immunostimulating, healing, antitumor, hemostatic, hypolipemic, antimicrobial actions, among others. Zinc oxide is an antimicrobial with extraordinary bactericidal and fungicidal efficacy. Studies have investigated the pink pepper essential oil and identified that it possesses diuretic, astringent, antidiarrheal, anti-inflammatory, healing, bactericidal, antiviral, analgesic, sedative, expectorant, antipyretic, vermifuge and antiseptic activity. Conclusion: chitosan, zinc oxide and pink pepper essential oil have, individually or in combination, potential for applications in areas such as active packaging, water treatment, dressings and others, as a result of the competence to minimize or eradicate proliferation of pathogenic microorganisms. Anacardiaceae; Hydrogel; Zinc Oxid; Polymers; Biological Products; Chitosan.RESUMENObjetivo: describir las propiedades y aplicaciones potenciales de la quitosana, óxido de zinc y aceite esencial de pimienta rosa. Método: estudio descriptivo, tipo informativo, mediante el levantamiento del universo de la producción científica. Resultados: la quitosana es un polímero que tiene características, tales como: biodegradabilidad, biocompatibilidad, atoxicidad, bajo costo, producto natural y existe en gran cantidad en la naturaleza. Es susceptible de ser manipulada en los formatos de láminas, películas, fibras y geles. Es una molécula extremadamente funcional, ejerciendo acción mucosidad, anticoagulante, inmunoestimulante, cicatrizante, antitumoral, hemostática, hipolipémica, antimicrobiana, entre otras. El óxido de zinc es un antimicrobiano con extraordinaria eficacia bactericida y fungicida. Los estudios han investigado el aceite esencial de la pimienta rosa e identificado que el posee actividad diurética, astringente, antidiarreica, anti-inflamatoria, cicatrizante, bactericida, antiviral, analgésica, sedante, expectorante, antipirética, vermífuga y antiséptica. Conclusión: la quitosana, el óxido de zinc y el aceite esencial de pimienta rosa presentan, individualmente o en conjunto, potencialidades para aplicaciones en áreas tales como envases activos, tratamiento de agua, curativos y otras, como consecuencia de la competencia para minimizar o erradicar la proliferación de micro-organismos patógenos. Descriptores: Anacardiaceae; Hidrogel; Óxido de Zinc; Polímeros; Productos Biológicos; Quitosano.

show abstract

Chitosan Hydrogel in combination with Nerolidol for healing wounds

Cited by 66 publications

References 25 publications

Biocompatible Gels of Chitosan–Buriti Oil for Potential Wound Healing Applications

Biocompatible Gels of Chitosan–Buriti Oil for Potential Wound Healing Applications

Enhancement of α-Mangostin Wound Healing Ability by Complexation with 2-Hydroxypropyl-β-Cyclodextrin in Hydrogel Formulation

Chitosan, zinc oxide and pink pepper essential oil: potential properties and applications

Contact Info

Product

Resources

About